MCL coexpression mm9:2106

Phase1 CAGE Peaks

	Short description
Mm9::chr14:51710764..51710835,+	p2@Ang p2@Rnase4
Mm9::chr16:56886206..56886238,-	p2@Tmem45a
Mm9::chr16:56886244..56886289,-	p1@Tmem45a
Mm9::chr3:88420116..88420170,+	p4@Arhgef2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043025	cell soma	0.00335623143161013
GO:0032311	angiogenin-PRI complex	0.00961485783158932
GO:0043198	dendritic shaft	0.0384488964201393
GO:0030426	growth cone	0.0480242611494664
GO:0030427	site of polarized growth	0.0480242611494664
GO:0004522	pancreatic ribonuclease activity	0.0480242611494664
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	0.0480242611494664
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	0.0480242611494664
GO:0017148	negative regulation of translation	0.0499288088486925
GO:0031327	negative regulation of cellular biosynthetic process	0.0499288088486925

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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