MCL coexpression mm9:409

Phase1 CAGE Peaks

	Short description
Mm9::chr10:102491237..102491291,-	p2@Alx1
Mm9::chr10:45588552..45588568,+	p@chr10:45588552..45588568 +
Mm9::chr10:50622895..50622905,+	p@chr10:50622895..50622905 +
Mm9::chr12:37259377..37259386,+	p@chr12:37259377..37259386 +
Mm9::chr13:115892012..115892032,-	p10@Itga1
Mm9::chr13:7174912..7174917,-	p@chr13:7174912..7174917 -
Mm9::chr15:98639918..98639923,-	p@chr15:98639918..98639923 -
Mm9::chr2:113205651..113205663,+	p@chr2:113205651..113205663 +
Mm9::chr3:132528811..132528861,+	p@chr3:132528811..132528861 +
Mm9::chr3:132546346..132546356,-	p@chr3:132546346..132546356 -
Mm9::chr3:54490675..54490702,-	p@chr3:54490675..54490702 -
Mm9::chr3:54490730..54490743,-	p@chr3:54490730..54490743 -
Mm9::chr5:16903685..16903695,-	p@chr5:16903685..16903695 -
Mm9::chr5:16903720..16903727,-	p@chr5:16903720..16903727 -
Mm9::chr5:53400291..53400314,-	p@chr5:53400291..53400314 -
Mm9::chr7:31992851..31992858,+	p@chr7:31992851..31992858 +
Mm9::chr8:108119034..108119056,+	p@chr8:108119034..108119056 +
Mm9::chr8:47515509..47515529,-	p@chr8:47515509..47515529 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	0.0256382161274507
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	0.0421083748790152
GO:0001658	ureteric bud branching	0.0421083748790152
GO:0005178	integrin binding	0.0421083748790152
GO:0001657	ureteric bud development	0.0421083748790152
GO:0001656	metanephros development	0.0421083748790152
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0421083748790152
GO:0032403	protein complex binding	0.0421083748790152
GO:0048754	branching morphogenesis of a tube	0.0421083748790152
GO:0001763	morphogenesis of a branching structure	0.0421083748790152
GO:0007160	cell-matrix adhesion	0.0421083748790152
GO:0009967	positive regulation of signal transduction	0.0421083748790152
GO:0031589	cell-substrate adhesion	0.0421083748790152
GO:0001822	kidney development	0.0421083748790152
GO:0001655	urogenital system development	0.0421083748790152
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0421083748790152

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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