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Coexpression cluster:C4073

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Full id: C4073_splenic_cord_adult_hairy_spleen_Multipotent_Burkitt



Phase1 CAGE Peaks

Hg19::chr21:27794750..27794757,+p@chr21:27794750..27794757
+
Hg19::chr2:111562736..111562747,+p3@ACOXL
Hg19::chr8:42623674..42623685,-p3@CHRNA6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0003997acyl-CoA oxidase activity0.0191762526007121
GO:0005892nicotinic acetylcholine-gated receptor-channel complex0.0191762526007121
GO:0016634oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor0.0191762526007121
GO:0015464acetylcholine receptor activity0.0191762526007121
GO:0042166acetylcholine binding0.0191762526007121
GO:0004889nicotinic acetylcholine-activated cation-selective channel activity0.0191762526007121
GO:0003995acyl-CoA dehydrogenase activity0.02357974527894
GO:0043176amine binding0.0275052468288009
GO:0005231excitatory extracellular ligand-gated ion channel activity0.0389860458602887
GO:0016627oxidoreductase activity, acting on the CH-CH group of donors0.0389860458602887
GO:0042579microbody0.0389860458602887
GO:0005777peroxisome0.0389860458602887
GO:0043235receptor complex0.0389860458602887
GO:0050660FAD binding0.0389860458602887
GO:0005230extracellular ligand-gated ion channel activity0.0389860458602887
GO:0030594neurotransmitter receptor activity0.0389860458602887
GO:0042165neurotransmitter binding0.0389860458602887
GO:0045211postsynaptic membrane0.0389860458602887
GO:0044456synapse part0.0389860458602887
GO:0015276ligand-gated ion channel activity0.0389860458602887
GO:0022834ligand-gated channel activity0.0389860458602887
GO:0006631fatty acid metabolic process0.0433233753343024



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
umbilical cord1.28e-1410
blastocyst1.28e-1410
blastula1.28e-1410
bilaminar disc1.28e-1410
inner cell mass1.28e-1410
cleaving embryo1.28e-1410
connecting stalk1.28e-1410
inner cell mass derived epiblast1.28e-1410
extraembryonic mesoderm1.28e-1410
blood6.02e-1015
haemolymphatic fluid6.02e-1015
organism substance6.02e-1015
Disease
Ontology termp-valuen
lymphoma3.22e-3810
anemia1.21e-161
non-Hodgkin lymphoma1.41e-161
cutaneous T cell lymphoma1.41e-161
mycosis fungoides1.41e-161
hematologic cancer1.30e-1051
immune system cancer1.30e-1051
hematopoietic system disease5.49e-092


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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