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Coexpression cluster:C8

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Full id: C8_Natural_CD8_Basophils_CD4_CD14_Peripheral_CD34



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data




Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br><br>



Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#105382083.346382280580687.96257119070932e-526.11472773960655e-49
BCL11A#533352274.253544457410043.26153564180878e-753.87081273744167e-72
BCL3#6021242.829485302287682.07423544351374e-246.44735343705749e-22
CEBPB#10512411.268855071217826.80057249868787e-050.00108649991003589
EBF1#18794522.658998028169871.59379437648377e-862.1070163403239e-83
ELF1#19974381.231867176986595.42659154992983e-072.51440902787543e-05
EP300#20333041.360157387563971.19405252342936e-088.91391361647169e-07
FOS#23532381.414473820024353.21996077710046e-082.16960957161029e-06
FOSL1#8061681.783701070484395.42555123003451e-060.000165587125924481
FOXA1#31691681.229642349997860.003395762632114260.0173278962982059
FOXA2#3170801.301477609123660.01134290731166360.0415941117489848
GATA1#26231621.450970884607441.64261712851743e-066.22472025708388e-05
GATA2#26241981.666774427505741.612389522416e-122.21866072900665e-10
IRF4#36621742.518576755279712.9589891052122e-281.08432934441845e-25
JUN#37252051.694273437535631.33492803586132e-132.05935818518937e-11
JUNB#3726761.536597148049150.0002017305440709150.0023966029225597
JUND#37272551.178097295361370.002976124841059290.0158623884804997
MAX#41492691.146458013159130.008691847422025020.0330253520904017
MEF2A#42051882.327428937260951.76653948863028e-266.00962923951328e-24
MEF2C#4208832.264757214589031.33582051403411e-111.65102672976579e-09
MXI1#46011831.204073717346730.005231765581633410.0242413649325737
NFKB1#47905562.015431482068542.54187348868515e-652.55260312773835e-62
NR4A1#316447.288274611092490.002282279127946350.0129549948281748
PAX5#50794011.766509760899813.10127007246155e-311.31130989918143e-28
PBX3#50901141.650102012079812.03474580505133e-071.09879429748581e-05
POLR2A#54308611.221239884423054.70592212466373e-169.1353494568356e-14
POU2F2#54523111.870544638017121.59517504349045e-275.74477539196892e-25
RFX5#59931621.289142373847820.0006067960352737130.00506661105915825
SMARCB1#65981051.265875268838530.0088773612688950.0336824360082149
SMARCC1#6599631.816903327038836.81763355733294e-060.000198225732487276
SP1#66673361.264634176390582.13024321125317e-067.75193277839963e-05
SPI1#66883221.744908962843011.40948911000144e-234.26682994665046e-21
STAT3#67741761.222870435600490.003395521286906220.0173275113692563
TAL1#6886901.775545245026172.06052981289665e-071.10585649089986e-05
TCF12#69382531.777093540457842.87714246728154e-196.89187803074351e-17
WRNIP1#56897241.74087129748020.007351561507300210.0303954763365371
ZEB1#69351391.550523150884153.08364634856496e-071.5490761952755e-05



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data