MCL coexpression mm9:100
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | 1.06955522168773e-05 |
| GO:0006351 | transcription, DNA-dependent | 1.06955522168773e-05 |
| GO:0032774 | RNA biosynthetic process | 1.06955522168773e-05 |
| GO:0045449 | regulation of transcription | 1.15739381032375e-05 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 1.1867205629498e-05 |
| GO:0006350 | transcription | 1.1867205629498e-05 |
| GO:0010468 | regulation of gene expression | 1.57070854974608e-05 |
| GO:0031323 | regulation of cellular metabolic process | 2.32376774256967e-05 |
| GO:0019222 | regulation of metabolic process | 3.30989259478468e-05 |
| GO:0016070 | RNA metabolic process | 4.17018828948098e-05 |
| GO:0050794 | regulation of cellular process | 8.05939042937337e-05 |
| GO:0050789 | regulation of biological process | 8.30519623796587e-05 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.000154209456836107 |
| GO:0010467 | gene expression | 0.000288456481903389 |
| GO:0065007 | biological regulation | 0.000506072611848329 |
| GO:0003677 | DNA binding | 0.00376362238179168 |
| GO:0043283 | biopolymer metabolic process | 0.00664035286554795 |
| GO:0003700 | transcription factor activity | 0.00709432958641498 |
| GO:0051098 | regulation of binding | 0.00928388962222668 |
| GO:0003676 | nucleic acid binding | 0.0225851821885137 |
| GO:0031536 | positive regulation of exit from mitosis | 0.0253407908040023 |
| GO:0031017 | exocrine pancreas development | 0.0253407908040023 |
| GO:0044451 | nucleoplasm part | 0.0273498646958529 |
| GO:0005654 | nucleoplasm | 0.032149813537008 |
| GO:0021985 | neurohypophysis development | 0.0371349305754187 |
| GO:0004351 | glutamate decarboxylase activity | 0.0371349305754187 |
| GO:0010458 | exit from mitosis | 0.0371349305754187 |
| GO:0007096 | regulation of exit from mitosis | 0.0371349305754187 |
| GO:0051100 | negative regulation of binding | 0.0371349305754187 |
| GO:0043392 | negative regulation of DNA binding | 0.0371349305754187 |
| GO:0031981 | nuclear lumen | 0.0463792531986173 |
| GO:0001957 | intramembranous ossification | 0.0463792531986173 |
| GO:0021854 | hypothalamus development | 0.0463792531986173 |
| GO:0014002 | astrocyte development | 0.0463792531986173 |
| GO:0016286 | small conductance calcium-activated potassium channel activity | 0.0463792531986173 |
| GO:0021979 | hypothalamus cell differentiation | 0.0463792531986173 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| CNS neuron (sensu Vertebrata) | 1.29e-15 | 23 |
| neuroblast (sensu Vertebrata) | 1.29e-15 | 23 |
| neuron | 1.03e-12 | 33 |
| neuronal stem cell | 1.03e-12 | 33 |
| neuroblast | 1.03e-12 | 33 |
| electrically signaling cell | 1.03e-12 | 33 |
| neuron of cerebral cortex | 6.32e-10 | 6 |
| electrically responsive cell | 8.35e-10 | 39 |
| electrically active cell | 8.35e-10 | 39 |
| neural cell | 3.44e-09 | 43 |
| ectodermal cell | 7.67e-09 | 44 |
| neurectodermal cell | 7.67e-09 | 44 |
| non-terminally differentiated cell | 2.49e-07 | 49 |
| Ontology term | p-value | n |
|---|---|---|
| neurectoderm | 3.13e-14 | 64 |
| neural plate | 3.13e-14 | 64 |
| presumptive neural plate | 3.13e-14 | 64 |
| ecto-epithelium | 4.13e-12 | 73 |
| pre-chordal neural plate | 4.94e-12 | 49 |
| ectoderm-derived structure | 2.54e-10 | 95 |
| ectoderm | 2.54e-10 | 95 |
| presumptive ectoderm | 2.54e-10 | 95 |
| neural tube | 1.24e-09 | 52 |
| neural rod | 1.24e-09 | 52 |
| future spinal cord | 1.24e-09 | 52 |
| neural keel | 1.24e-09 | 52 |
| central nervous system | 2.25e-09 | 73 |
| regional part of nervous system | 5.16e-09 | 54 |
| nervous system | 6.79e-09 | 75 |
| gray matter | 2.36e-08 | 34 |
| regional part of forebrain | 7.07e-08 | 39 |
| forebrain | 7.07e-08 | 39 |
| future forebrain | 7.07e-08 | 39 |
| structure with developmental contribution from neural crest | 1.16e-07 | 92 |
| anterior neural tube | 1.50e-07 | 40 |
| regional part of spinal cord | 8.03e-07 | 5 |
| gray matter of spinal cord | 8.03e-07 | 5 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
