MCL coexpression mm9:480

Phase1 CAGE Peaks

	Short description
Mm9::chr10:41238883..41238909,-	p@chr10:41238883..41238909 -
Mm9::chr10:77069406..77069425,+	p8@Sumo3
Mm9::chr10:79623652..79623666,-	p@chr10:79623652..79623666 -
Mm9::chr11:117515863..117515866,-	p@chr11:117515863..117515866 -
Mm9::chr12:111829796..111829818,-	p@chr12:111829796..111829818 -
Mm9::chr13:93380879..93380905,-	p@chr13:93380879..93380905 -
Mm9::chr15:96116436..96116455,+	p@chr15:96116436..96116455 +
Mm9::chr18:31794423..31794465,-	p@chr18:31794423..31794465 -
Mm9::chr19:53674495..53674503,-	p@chr19:53674495..53674503 -
Mm9::chr19:7292351..7292358,+	p@chr19:7292351..7292358 +
Mm9::chr3:146184120..146184147,+	p@chr3:146184120..146184147 +
Mm9::chr5:112705376..112705388,-	p@chr5:112705376..112705388 -
Mm9::chr5:139853670..139853699,+	p1@D830046C22Rik p3@Gpr146
Mm9::chr6:85401482..85401496,+	p4@Cct7
Mm9::chr8:32260438..32260442,-	p1@ENSMUST00000157627

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019949	SUMO conjugating enzyme activity	0.00945807736893712
GO:0016925	protein sumoylation	0.00945807736893712
GO:0005832	chaperonin-containing T-complex	0.00945807736893712
GO:0032446	protein modification by small protein conjugation	0.0455539663794155
GO:0051082	unfolded protein binding	0.0469544530664094

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
hematopoietic cell	1.86e-13	32
hematopoietic oligopotent progenitor cell	1.86e-13	32
hematopoietic stem cell	1.86e-13	32
angioblastic mesenchymal cell	1.86e-13	32
hematopoietic multipotent progenitor cell	1.86e-13	32
nucleate cell	2.95e-11	16
hematopoietic lineage restricted progenitor cell	2.00e-10	25
lymphoid lineage restricted progenitor cell	1.11e-09	12
T cell	6.14e-09	11
pro-T cell	6.14e-09	11
connective tissue cell	6.75e-09	46
mesenchymal cell	6.75e-09	46
lymphocyte	8.27e-09	13
common lymphoid progenitor	8.27e-09	13
somatic cell	3.56e-08	118
mature alpha-beta T cell	8.38e-08	9
alpha-beta T cell	8.38e-08	9
immature T cell	8.38e-08	9
mature T cell	8.38e-08	9
immature alpha-beta T cell	8.38e-08	9
intestinal epithelial cell	8.53e-08	9
epithelial cell of alimentary canal	8.53e-08	9
stem cell	2.02e-07	97
motile cell	2.52e-07	54
CD4-positive, alpha-beta T cell	4.34e-07	8
animal cell	5.48e-07	115
eukaryotic cell	5.48e-07	115
leukocyte	6.09e-07	17
nongranular leukocyte	6.09e-07	17

Uber Anatomy

Ontology term	p-value	n
connective tissue	6.75e-09	46
epithelium of mucosa	8.53e-08	9
gastrointestinal system epithelium	8.53e-08	9
intestinal epithelium	8.53e-08	9
simple columnar epithelium	3.24e-07	11
unilaminar epithelium	5.19e-07	66

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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