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Coexpression cluster:C3543

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Full id: C3543_heart_Lymphatic_mature_retinoblastoma_medulla_Renal_Endothelial



Phase1 CAGE Peaks

Hg19::chr16:20911978..20911991,+p10@LYRM1
Hg19::chr16:20912007..20912027,+p6@LYRM1
Hg19::chr16:20912031..20912042,+p14@LYRM1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.14.74607
MA0046.11.31611
MA0048.10.341392
MA0050.11.90116
MA0051.13.54769
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.13.76647
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.12.91768
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.94723
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.25.2404
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.11.38935
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.21.90288
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467322.46317452600878.81932387510763e-050.00129510878261019
BRCA1#672320.18423064322380.0001215704860271640.001641036576217
CCNT2#90536.336201576962630.003930750035764890.0189723450866646
CEBPB#105137.971147625824820.001974187055288560.0115108375316705
CHD2#1106310.34402283411690.0009033701102746880.00659631342704175
E2F1#186934.907389214879320.008460985347239390.0324706712971388
EGR1#195834.988179094810140.008056488137383440.0320013526254208
ELF1#199734.258097958807540.01295179875054610.0461332461276315
ELK4#2005316.2356816584680.0002336043955745990.00255523769055462
EP300#203336.77394172622320.003216880500103790.0167264653266126
FOXA1#3169311.08141974938550.000734755275698670.00580506136914239
GABPB1#255337.067683836182170.002832212825417420.0153898790465021
HMGN3#932438.178547723350590.001827766942164210.0108571352333459
JUN#3725312.51282919233630.0005103313992726250.0044371046460734
JUND#372736.994663941871030.002921845042734990.0156497550858095
MYC#460935.22228187160940.007020843755740150.0294005573779369
NANOG#79923329.24477848101273.99627955670032e-050.000736747468000397
NFKB1#479035.488063424193840.006049381815655430.0269236933199198
REST#597839.650028716128020.001112636247114590.00766508027786284
RFX5#5993312.04791082719510.0005717246050312580.00484072525535951
SIN3A#2594235.408884726815140.006318961977991520.0276139616728506
SIX5#147912317.0867153554590.0002004060546325010.00239448666511426
SMARCB1#6598212.16847718743830.008675002221921740.0329793446802302
SP1#666735.69838137814090.005403962701712170.0246079991543108
SRF#6722313.79717826216780.0003806615025800190.00374631612023696
STAT1#6772320.70658749719920.0001125992441046670.00154692876283179
STAT3#6774310.51946499715420.0008589184530415310.00642214950724545
TFAP2C#7022310.80922860986020.0007916746575753130.00614551133956504
THAP1#55145331.36914460285133.23800758564397e-050.000645987152315321
TRIM28#10155318.59052504526250.0001555969297255280.001967835764544
USF1#739136.361499277207960.00388404057290560.0189988906090435
ZBTB7A#5134137.35190930787590.002516255860282270.0139926119904169
ZNF263#1012738.221841637010680.001799043925565870.0109225874050793



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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