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CL:0000057

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Name:fibroblast
Namespace:cell;;efo
Definition:"A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." ISBN:0517223651, MESH:A.11.329.228
Xrefs:
links:

BTO:0000452

FMA:63877
Comments:These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:CL:0002320(connective tissue cell)
develops_from:CL:0000134(mesenchymal cell)



Children


is a:CL:0000005 (fibroblast neural crest derived),CL:0000632 (hepatic stellate cell),CL:0002334 (preadipocyte),CL:0002548 (cardiac fibroblast),CL:0002549 (fibroblast of choroid plexus),CL:0002550 (fibroblast of the conjuctiva),CL:0002552 (fibroblast of gingiva),CL:0002553 (lung fibroblast),CL:0002554 (fibroblast of lymphatic vessel),CL:0002555 (fibroblast of mammary gland),CL:0002556 (fibroblast of periodontium),CL:0002557 (fibroblast of pulmonary artery),CL:0002558 (fibroblast of villous mesenchyme),CL:0002620 (skin fibroblast),CL:1000306 (fibroblast of tunica adventitia of artery)
derives from:FF:0000057 (fibroblast sample),FF:0000107 (mouse embryonic fibroblast sample),FF:0100453 (fibroblast cell line sample)
develops from:CL:0000135 (fibrocyte)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000057 (fibroblast), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data