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UBERON:0001264

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Name:pancreas
Definition:"An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. The mature pancreas of higher vertebrates and mammals comprises two major functional units: the exocrine pancreas, which is responsible for the production of digestive enzymes to be secreted into the gut lumen, and the endocrine pancreas, which has its role in the synthesis of several hormones with key regulatory functions in food uptake and metabolism. The exocrine portion constitutes the majority of the mass of the pancreas, and contains only two different cell types, the secretory acinar cells and the ductular cells. The endocrine portion, which comprises only 1遯ｶ�2% of the total mass, contains five different cell types, which are organized into mixed functional assemblies referred to as the islets of Langerhans[PMID]." [GO:0031016, PMID:16417468, Wikipedia:Pancreas]
Xrefs:
links:

AAO:0010112
BTO:0000988
EFO:0000855
EHDAA2:0001367
EHDAA:6893
EMAPA:17503
EMAPA:18816
EV:0100092
FMA:7198
GAID:334
galen:Pancreas
[1]
[ 200px-Illu_pancrease.svg.png 200px-Illu_pancrease.svg.png]
MA:0000120
MAT:0000075
MESH:A.03.734
MIAA:0000075
ncithesaurus:Pancreas
OpenCyc:Mx4rvVimZZwpEbGdrcN5Y29ycA
SCTID:181277001
TAO:0000140
VHOG:0000050
XAO:0000136

ZFA:0000140
Comments:taxon notes: As a secretory organ serving exocrine and endocrine functions, the pancreas is specific to the vertebrates[PMID:16417468] Hagfishes and lampreys are unique in the complete separation of their endocrine pancreas (islet or- gan) and their exocrine pancreas (50). The endocrine and exocrine pancreas are coassociated in crown gnathostomes (50). In Branchiostoma and Ciona, there is no diverticulum as there is in hagfishes, lampreys, and gnathostomes, only dispersed insulin-secreting cells in the walls of the gastrointestinal tract (51, 52) [PMID:20959416]
Alt_id: UBERON:FMA_16017-FMA_16018-FMA_7198-MA_0000120-MA_0001582-MA_0002415-MIAA_0000075-XAO_0000136-XAO_0000137-ZFA_0000140-ZFA_0001249-ZFA_0001260
Subset: major_organ
organ_slim
uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0002075(viscus)
part_of:UBERON:0000949(endocrine system)



Children

is a:FF:10603-108E9 (embryonic pancreas cell line:2C6),FF:10604-108F1 (embryonic pancreas cell line:1B2C6),FF:10605-108F2 (embryonic pancreas cell line:1C3D3),FF:10606-108F3 (embryonic pancreas cell line:1C3IKEI)
derives from:FF:0010049 (human pancreas - adult sample),FF:0011251 (mouse pancreas- neonate N01 sample),FF:0011253 (mouse pancreas- embryo E18 sample),FF:0011254 (mouse pancreas- neonate N02 sample),FF:0011255 (mouse pancreas- neonate N30 sample),FF:0011256 (mouse pancreas- neonate N25 sample),FF:0011257 (mouse pancreas- embryo E15 sample),FF:0011258 (mouse pancreas- embryo E17 sample),FF:0011262 (mouse pancreas- embryo E14 sample),FF:0011263 (mouse pancreas- embryo E16 sample),FF:0011266 (mouse pancreas- neonate N00 sample),FF:0011267 (mouse pancreas- neonate N16 sample),FF:0011315 (mouse pancreas- adult sample),FF:0100794 (pancreatic cancer cell line sample)
part of:UBERON:0000016 (endocrine pancreas),CL:0000083 (epithelial cell of pancreas),CL:0000173 (pancreatic D cell),CL:0002574 (stromal cell of pancreas),UBERON:0007329 (pancreatic duct)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001264 (pancreas), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.31e-86FFCP PHASE1:Mm9::chr6:30494986..30494997,+#_95623124942f1e1aa240aa22e89ee361p@chr6:30494986..30494997, +
1.31e-86FFCP PHASE2:Mm9::chr6:30494986..30494997,+#_95623124942f1e1aa240aa22e89ee361p@chr6:30494986..30494997, +
1.31e-86FFCP PHASE2:Mm9::chr19:58804381..58804392,+#_95623124942f1e1aa240aa22e89ee361p@chr19:58804381..58804392, +
1.31e-86FFCP PHASE1:Mm9::chr19:58804381..58804392,+#_95623124942f1e1aa240aa22e89ee361p@chr19:58804381..58804392, +
2.27e-79FFCP PHASE2:Mm9::chr2:19410182..19410200,+#_9c8def3879a09329e279f785ba2f101dp@chr2:19410182..19410200, +
2.27e-79FFCP PHASE2:Mm9::chr8:114225711..114225718,+#_9c8def3879a09329e279f785ba2f101dp@chr8:114225711..114225718, +
2.27e-79FFCP PHASE1:Mm9::chr9:60297477..60297496,-#_9c8def3879a09329e279f785ba2f101dp@chr9:60297477..60297496, -
2.27e-79FFCP PHASE2:Mm9::chr2:19374076..19374083,+#_9c8def3879a09329e279f785ba2f101dp2@ENSMUST00000149577
2.27e-79FFCP PHASE2:Mm9::chr9:60297477..60297496,-#_9c8def3879a09329e279f785ba2f101dp@chr9:60297477..60297496, -
2.27e-79FFCP PHASE2:Mm9::chr8:114214659..114214665,-#_9c8def3879a09329e279f785ba2f101dp@chr8:114214659..114214665, -
2.27e-79FFCP PHASE1:Mm9::chr5:54068360..54068364,+#_9c8def3879a09329e279f785ba2f101dp@chr5:54068360..54068364, +
2.27e-79FFCP PHASE1:Mm9::chr2:19374076..19374083,+#_9c8def3879a09329e279f785ba2f101dp2@ENSMUST00000149577
2.27e-79FFCP PHASE1:Mm9::chr15:52127064..52127100,+#_9c8def3879a09329e279f785ba2f101dp2@Slc30a8
2.27e-79FFCP PHASE2:Mm9::chr15:52127064..52127100,+#_9c8def3879a09329e279f785ba2f101dp2@Slc30a8
2.27e-79FFCP PHASE1:Mm9::chr8:114212440..114212443,-#_9c8def3879a09329e279f785ba2f101dp@chr8:114212440..114212443, -
2.27e-79FFCP PHASE2:Mm9::chr5:54068360..54068364,+#_9c8def3879a09329e279f785ba2f101dp@chr5:54068360..54068364, +
2.27e-79FFCP PHASE1:Mm9::chr8:114225711..114225718,+#_9c8def3879a09329e279f785ba2f101dp@chr8:114225711..114225718, +
2.27e-79FFCP PHASE1:Mm9::chr2:19410182..19410200,+#_9c8def3879a09329e279f785ba2f101dp@chr2:19410182..19410200, +
2.27e-79FFCP PHASE1:Mm9::chr8:114214659..114214665,-#_9c8def3879a09329e279f785ba2f101dp@chr8:114214659..114214665, -
2.27e-79FFCP PHASE2:Mm9::chr8:114212440..114212443,-#_9c8def3879a09329e279f785ba2f101dp@chr8:114212440..114212443, -
4.35e-73FFCP PHASE2:Mm9::chr19:58818563..58818576,-#_497d6ea7b5f7be3b952b7920d8e1f743p@chr19:58818563..58818576, -
4.35e-73FFCP PHASE2:Mm9::chr5:54097752..54097764,-#_497d6ea7b5f7be3b952b7920d8e1f743p@chr5:54097752..54097764, -
4.35e-73FFCP PHASE1:Mm9::chr8:114215028..114215041,-#_497d6ea7b5f7be3b952b7920d8e1f743p2@Ctrb1
4.35e-73FFCP PHASE2:Mm9::chr5:54098551..54098567,-#_497d6ea7b5f7be3b952b7920d8e1f743p4@Cckar
4.35e-73FFCP PHASE1:Mm9::chr19:58818563..58818576,-#_497d6ea7b5f7be3b952b7920d8e1f743p@chr19:58818563..58818576, -
4.35e-73FFCP PHASE1:Mm9::chr5:54097752..54097764,-#_497d6ea7b5f7be3b952b7920d8e1f743p@chr5:54097752..54097764, -
4.35e-73FFCP PHASE1:Mm9::chr15:52127197..52127209,+#_497d6ea7b5f7be3b952b7920d8e1f743p1@Slc30a8
4.35e-73FFCP PHASE2:Mm9::chr15:52127197..52127209,+#_497d6ea7b5f7be3b952b7920d8e1f743p1@Slc30a8
4.35e-73FFCP PHASE1:Mm9::chr5:54098551..54098567,-#_497d6ea7b5f7be3b952b7920d8e1f743p4@Cckar
4.35e-73FFCP PHASE2:Mm9::chr8:114215028..114215041,-#_497d6ea7b5f7be3b952b7920d8e1f743p2@Ctrb1
6.98e-73FFCP PHASE2:Mm9::chr18:34531496..34531499,-#_da602d338117dcce7924b6920a6a9919p@chr18:34531496..34531499, -
6.98e-73FFCP PHASE1:Mm9::chr18:34531496..34531499,-#_da602d338117dcce7924b6920a6a9919p@chr18:34531496..34531499, -
3.62e-72FFCP PHASE2:Mm9::chr7:29325737..29325747,+#_ac692940a232fbe86f9b38261904fe83p3@Sycn
3.62e-72FFCP PHASE2:Mm9::chr5:43495214..43495226,+#_ac692940a232fbe86f9b38261904fe83p@chr5:43495214..43495226, +
3.62e-72FFCP PHASE1:Mm9::chr16:62881258..62881265,-#_ac692940a232fbe86f9b38261904fe83p@chr16:62881258..62881265, -
3.62e-72FFCP PHASE1:Mm9::chr19:58812762..58812772,+#_ac692940a232fbe86f9b38261904fe83p@chr19:58812762..58812772, +
3.62e-72FFCP PHASE2:Mm9::chr19:58813935..58813941,+#_ac692940a232fbe86f9b38261904fe83p@chr19:58813935..58813941, +
3.62e-72FFCP PHASE1:Mm9::chr5:43495214..43495226,+#_ac692940a232fbe86f9b38261904fe83p@chr5:43495214..43495226, +
3.62e-72FFCP PHASE1:Mm9::chr4:141378178..141378181,-#_ac692940a232fbe86f9b38261904fe83p@chr4:141378178..141378181, -
3.62e-72FFCP PHASE2:Mm9::chr16:62881258..62881265,-#_ac692940a232fbe86f9b38261904fe83p@chr16:62881258..62881265, -
3.62e-72FFCP PHASE1:Mm9::chr8:114214342..114214354,-#_ac692940a232fbe86f9b38261904fe83p@chr8:114214342..114214354, -
3.62e-72FFCP PHASE1:Mm9::chr7:130565024..130565035,+#_ac692940a232fbe86f9b38261904fe83p2@Lcmt1
3.62e-72FFCP PHASE1:Mm9::chr19:58812793..58812802,+#_ac692940a232fbe86f9b38261904fe83p@chr19:58812793..58812802, +
3.62e-72FFCP PHASE1:Mm9::chr18:17942879..17942880,-#_ac692940a232fbe86f9b38261904fe83p@chr18:17942879..17942880, -
3.62e-72FFCP PHASE1:Mm9::chr6:51270916..51270924,-#_ac692940a232fbe86f9b38261904fe83p@chr6:51270916..51270924, -
3.62e-72FFCP PHASE2:Mm9::chr18:39522574..39522590,+#_ac692940a232fbe86f9b38261904fe83p@chr18:39522574..39522590, +
3.62e-72FFCP PHASE2:Mm9::chr19:58812762..58812772,+#_ac692940a232fbe86f9b38261904fe83p@chr19:58812762..58812772, +
3.62e-72FFCP PHASE2:Mm9::chr18:17942879..17942880,-#_ac692940a232fbe86f9b38261904fe83p@chr18:17942879..17942880, -
3.62e-72FFCP PHASE1:Mm9::chr15:37020111..37020125,+#_ac692940a232fbe86f9b38261904fe83p@chr15:37020111..37020125, +
3.62e-72FFCP PHASE1:Mm9::chr19:58812844..58812855,+#_ac692940a232fbe86f9b38261904fe83p@chr19:58812844..58812855, +
3.62e-72FFCP PHASE1:Mm9::chr7:29325737..29325747,+#_ac692940a232fbe86f9b38261904fe83p3@Sycn
3.62e-72FFCP PHASE2:Mm9::chr7:130565024..130565035,+#_ac692940a232fbe86f9b38261904fe83p2@Lcmt1
3.62e-72FFCP PHASE1:Mm9::chr8:114210563..114210566,+#_ac692940a232fbe86f9b38261904fe83p@chr8:114210563..114210566, +
3.62e-72FFCP PHASE2:Mm9::chr7:31243262..31243273,+#_ac692940a232fbe86f9b38261904fe83p6@Nphs1
3.62e-72FFCP PHASE2:Mm9::chr11:104162667..104162680,-#_ac692940a232fbe86f9b38261904fe83p@chr11:104162667..104162680, -
3.62e-72FFCP PHASE2:Mm9::chr19:58812793..58812802,+#_ac692940a232fbe86f9b38261904fe83p@chr19:58812793..58812802, +
3.62e-72FFCP PHASE2:Mm9::chr8:114210563..114210566,+#_ac692940a232fbe86f9b38261904fe83p@chr8:114210563..114210566, +
3.62e-72FFCP PHASE2:Mm9::chr15:37020111..37020125,+#_ac692940a232fbe86f9b38261904fe83p@chr15:37020111..37020125, +
3.62e-72FFCP PHASE1:Mm9::chr19:58813935..58813941,+#_ac692940a232fbe86f9b38261904fe83p@chr19:58813935..58813941, +
3.62e-72FFCP PHASE2:Mm9::chr4:141378178..141378181,-#_ac692940a232fbe86f9b38261904fe83p@chr4:141378178..141378181, -
3.62e-72FFCP PHASE1:Mm9::chr11:104162667..104162680,-#_ac692940a232fbe86f9b38261904fe83p@chr11:104162667..104162680, -
3.62e-72FFCP PHASE2:Mm9::chr6:51270916..51270924,-#_ac692940a232fbe86f9b38261904fe83p@chr6:51270916..51270924, -
3.62e-72FFCP PHASE2:Mm9::chr8:114214342..114214354,-#_ac692940a232fbe86f9b38261904fe83p@chr8:114214342..114214354, -
3.62e-72FFCP PHASE1:Mm9::chr7:31243262..31243273,+#_ac692940a232fbe86f9b38261904fe83p6@Nphs1
3.62e-72FFCP PHASE2:Mm9::chr19:58812844..58812855,+#_ac692940a232fbe86f9b38261904fe83p@chr19:58812844..58812855, +
3.62e-72FFCP PHASE1:Mm9::chr18:39522574..39522590,+#_ac692940a232fbe86f9b38261904fe83p@chr18:39522574..39522590, +
2.98e-70FFCP PHASE2:Mm9::chr2:19353621..19353653,-#_c284af8bbde2a585896fdd25b669032fp1@ENSMUST00000137714
2.98e-70FFCP PHASE2:Mm9::chr2:28335694..28335705,+#_c284af8bbde2a585896fdd25b669032fp@chr2:28335694..28335705, +
2.98e-70FFCP PHASE1:Mm9::chr2:28335694..28335705,+#_c284af8bbde2a585896fdd25b669032fp@chr2:28335694..28335705, +
2.98e-70FFCP PHASE1:Mm9::chr2:19353621..19353653,-#_c284af8bbde2a585896fdd25b669032fp1@ENSMUST00000137714
9.03e-68FFCP PHASE2:Mm9::chr8:114214598..114214609,-#_ce9a9b80965890e01a615eafa55f5268p@chr8:114214598..114214609, -
9.03e-68FFCP PHASE1:Mm9::chr8:114214263..114214282,-#_ce9a9b80965890e01a615eafa55f5268p@chr8:114214263..114214282, -
9.03e-68FFCP PHASE2:Mm9::chr19:58811529..58811552,-#_ce9a9b80965890e01a615eafa55f5268p@chr19:58811529..58811552, -
9.03e-68FFCP PHASE1:Mm9::chr3:112959660..112959680,-#_ce9a9b80965890e01a615eafa55f5268p1@Amy2b
9.03e-68FFCP PHASE2:Mm9::chr3:112959660..112959680,-#_ce9a9b80965890e01a615eafa55f5268p1@Amy2b
9.03e-68FFCP PHASE1:Mm9::chr19:58811529..58811552,-#_ce9a9b80965890e01a615eafa55f5268p@chr19:58811529..58811552, -
9.03e-68FFCP PHASE1:Mm9::chr8:114214598..114214609,-#_ce9a9b80965890e01a615eafa55f5268p@chr8:114214598..114214609, -
9.03e-68FFCP PHASE2:Mm9::chr8:114214263..114214282,-#_ce9a9b80965890e01a615eafa55f5268p@chr8:114214263..114214282, -
1.05e-67FFCP PHASE1:Mm9::chr6:51270886..51270895,-#_cc5f11c04f62ecfd926da03b52be767ap@chr6:51270886..51270895, -
1.05e-67FFCP PHASE1:Mm9::chr19:58815004..58815018,+#_cc5f11c04f62ecfd926da03b52be767ap@chr19:58815004..58815018, +
1.05e-67FFCP PHASE2:Mm9::chr6:51270886..51270895,-#_cc5f11c04f62ecfd926da03b52be767ap@chr6:51270886..51270895, -
1.05e-67FFCP PHASE2:Mm9::chr19:58815004..58815018,+#_cc5f11c04f62ecfd926da03b52be767ap@chr19:58815004..58815018, +
1.21e-67FFCP PHASE2:Mm9::chr4:57024496..57024516,-#_79b59eab01cb34948a6e792a2a5d1b5dp@chr4:57024496..57024516, -
1.21e-67FFCP PHASE1:Mm9::chr16:21558663..21558681,+#_79b59eab01cb34948a6e792a2a5d1b5dp@chr16:21558663..21558681, +
1.21e-67FFCP PHASE1:Mm9::chr4:57024496..57024516,-#_79b59eab01cb34948a6e792a2a5d1b5dp@chr4:57024496..57024516, -
1.21e-67FFCP PHASE2:Mm9::chr16:21558663..21558681,+#_79b59eab01cb34948a6e792a2a5d1b5dp@chr16:21558663..21558681, +
1.62e-67FFCP PHASE2:Mm9::chr6:30595230..30595247,-#_713a8ba06339bece4c76464e002e3863p@chr6:30595230..30595247, -
1.62e-67FFCP PHASE1:Mm9::chr6:30595230..30595247,-#_713a8ba06339bece4c76464e002e3863p@chr6:30595230..30595247, -
4.75e-66FFCP PHASE2:Mm9::chr9:69950924..69950949,-#_130f0c0bb97506f8e7b37c9f3f919ab6p4@Fam81a
4.75e-66FFCP PHASE1:Mm9::chr9:69950924..69950949,-#_130f0c0bb97506f8e7b37c9f3f919ab6p4@Fam81a
5.41e-66FFCP PHASE1:Mm9::chr7:31243299..31243312,+#_0d8dfd15a549484001bc51a38a76e63fp3@Nphs1
5.41e-66FFCP PHASE2:Mm9::chr7:31243299..31243312,+#_0d8dfd15a549484001bc51a38a76e63fp3@Nphs1
6.69e-66FFCP PHASE2:Mm9::chr15:72760619..72760646,-#_9c3e456c31f00beb9d3f3a7b4a8a54b3p@chr15:72760619..72760646, -
6.69e-66FFCP PHASE2:Mm9::chr17:24877002..24877012,+#_9c3e456c31f00beb9d3f3a7b4a8a54b3p@chr17:24877002..24877012, +
6.69e-66FFCP PHASE1:Mm9::chr8:114211003..114211012,+#_9c3e456c31f00beb9d3f3a7b4a8a54b3p@chr8:114211003..114211012, +
6.69e-66FFCP PHASE1:Mm9::chr3:146867602..146867605,-#_9c3e456c31f00beb9d3f3a7b4a8a54b3p@chr3:146867602..146867605, -
6.69e-66FFCP PHASE2:Mm9::chr8:114211003..114211012,+#_9c3e456c31f00beb9d3f3a7b4a8a54b3p@chr8:114211003..114211012, +
6.69e-66FFCP PHASE1:Mm9::chr13:59680417..59680420,+#_9c3e456c31f00beb9d3f3a7b4a8a54b3p@chr13:59680417..59680420, +
6.69e-66FFCP PHASE2:Mm9::chr13:59680417..59680420,+#_9c3e456c31f00beb9d3f3a7b4a8a54b3p@chr13:59680417..59680420, +
6.69e-66FFCP PHASE2:Mm9::chr3:146867602..146867605,-#_9c3e456c31f00beb9d3f3a7b4a8a54b3p@chr3:146867602..146867605, -










Property "Property value" (as page type) with input value "UBPROP:0000001 "Organ which secretes a fluid containing enzymes that aid in the digestion of food.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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