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CL:0000556

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Name:megakaryocyte
Namespace:cell
Definition:"A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." [ISBN:0721601464, MESH:D008533]
Xrefs:
links:

BTO:0000843

FMA:83555
Synonyms: "megacaryocyte" EXACT []
"megalocaryocyte" EXACT []
"megalokaryocyte" EXACT []
Comments:Megakaryocytes are reportedly CD181-positive and CD182-positive.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data


Parents

is_a:CL:0000414(),CL:0000763(myeloid cell)
disjoint_from:CL:0000764(erythroid lineage cell)
develops_from:CL:0000553(megakaryocyte progenitor cell)
part_of:UBERON:0002371(bone marrow)



Children


is a:CL:0002027 (CD9-positive, CD41-positive megakaryocyte cell),FF:0101549 (megakaryocytic cell line)
derives from:FF:0011468 (mouse CD41-positive megakaryocyte control sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000556 (megakaryocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data