AoSMC response to IL1b
From FANTOM5_SSTAR
Series: | IN_VITRO DIFFERENTIATION SERIES |
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Species: | Human (Homo sapiens) |
Genomic View: | Zenbu |
Expression table: | FILE |
Link to TET: | TET |
Sample providers : | Levon Khachigian |
Germ layer: | mesoderm |
Primary cells or cell line: | primary cells |
Time span: | 6 hours |
Number of time points: | 10 |
CollapseOverview |
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Vascular smooth muscle cells (SMCs) are key components in our blood vessels, and show remarkable plasticity. SMCs are normally growth-quiescent in the normal adult vessels, but are activated by injury, or exposure to growth factors, such as fibroblast growth factor-2 (FGF-2) and pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta). These cues are sensed by these cells through changes in immediate-early gene expression, and can lead to increased proliferation and migration. These responses are associated with the initiation and progression of a range of vascular diseases including atherosclerosis, post-angioplasty restenosis and bypass graft stenosis. |
ExpandSample description |
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ExpandQuality control |
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Profiled time course samples
Only samples that passed quality controls (Arner et al. 2015) are shown here. The entire set of samples are downloadable from FANTOM5 human / mouse samples