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CL:0000576

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Name:monocyte
Namespace:FANTOM
Definition:"Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells." [GO_REF:0000031, http://www.clt.astate.edu/wwilliam/, MESH:A.11.118.637.555.652]
Xrefs:
links:

BTO:0000876

FMA:62864
Comments:Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000766(myeloid leukocyte),CL:0002087(nongranular leukocyte)
develops_from:CL:0000559(promonocyte)



Children


is a:CL:0000860 (classical monocyte),CL:0000875 (non-classical monocyte),CL:0001054 (CD14-positive monocyte),CL:0002393 (intermediate monocyte),FF:11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1),FF:11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2),FF:11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3)
derives from:FF:0000024 (human CD14-positive monocyte sample),FF:0000044 (human monocyte immature derived dendritic cell sample),FF:0000566 (human Monocyte-derived macrophages 0min after LPS treatment sample),FF:0000567 (human Monocyte-derived macrophages 15min after LPS treatment sample),FF:0000568 (human Monocyte-derived macrophages 30min after LPS treatment sample),FF:0000569 (human Monocyte-derived macrophages 45min after LPS treatment sample),FF:0000570 (human Monocyte-derived macrophages 1h after LPS treatment sample),FF:0000571 (human Monocyte-derived macrophages 80min after LPS treatment sample),FF:0000572 (human Monocyte-derived macrophages 100min after LPS treatment sample),FF:0000573 (human Monocyte-derived macrophages 2h after LPS treatment sample),FF:0000574 (human Monocyte-derived macrophages 2.5h after LPS treatment sample),FF:0000575 (human Monocyte-derived macrophages 3h after LPS treatment sample),FF:0000576 (human Monocyte-derived macrophages 3.5h after LPS treatment sample),FF:0000577 (human Monocyte-derived macrophages 4h after LPS treatment sample),FF:0000578 (human Monocyte-derived macrophages 5h after LPS treatment sample),FF:0000579 (human Monocyte-derived macrophages 6h after LPS treatment sample),FF:0000580 (human Monocyte-derived macrophages 7h after LPS treatment sample),FF:0000581 (human Monocyte-derived macrophages 8h after LPS treatment sample),FF:0000582 (human Monocyte-derived macrophages 10h after LPS treatment sample),FF:0000583 (human Monocyte-derived macrophages 12h after LPS treatment sample),FF:0000584 (human Monocyte-derived macrophages 14h after LPS treatment sample),FF:0000585 (human Monocyte-derived macrophages 16h after LPS treatment sample),FF:0000586 (human Monocyte-derived macrophages 18h after LPS treatment sample),FF:0000587 (human Monocyte-derived macrophages 20h after LPS treatment sample),FF:0000588 (human Monocyte-derived macrophages 22h after LPS treatment sample),FF:0000589 (human Monocyte-derived macrophages 24h after LPS treatment sample),FF:0000590 (human Monocyte-derived macrophages 36h after LPS treatment sample),FF:0000591 (human Monocyte-derived macrophages 48h after LPS treatment sample),FF:0102332 (monocytic leukemia cell line sample)
develops from:CL:0000092 (osteoclast),CL:0000235 (macrophage)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

  • 10399-106A3 (acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh))
  • 10400-106A4 (acute myeloid leukemia (FAB M5) cell line:THP-1 (revived))
  • 10405-106A9 (acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed))
  • 11224-116B9 (CD14+ Monocytes, donor1)
  • 11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1)
  • 11305-117B9 (CD14+ Monocytes, donor2)
  • 11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2)
  • 11381-118B4 (CD14+ Monocytes, donor3)
  • 11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3)
  • 11788-124B6 (CD14+CD16- Monocytes, donor1)

... further results Mouse (Mus musculus)

  • 10399-106A3 (acute myeloid leukemia (FAB M5) cell line:THP-1 (fresh))
  • 10400-106A4 (acute myeloid leukemia (FAB M5) cell line:THP-1 (revived))
  • 10405-106A9 (acute myeloid leukemia (FAB M5) cell line:THP-1 (thawed))
  • 11224-116B9 (CD14+ Monocytes, donor1)
  • 11229-116C5 (CD14+ monocyte derived endothelial progenitor cells, donor1)
  • 11305-117B9 (CD14+ Monocytes, donor2)
  • 11310-117C5 (CD14+ monocyte derived endothelial progenitor cells, donor2)
  • 11381-118B4 (CD14+ Monocytes, donor3)
  • 11386-118B9 (CD14+ monocyte derived endothelial progenitor cells, donor3)
  • 11788-124B6 (CD14+CD16- Monocytes, donor1)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000576 (monocyte), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.04e-147FFCP PHASE2:Hg19::chr7:77050554..77050601,+#_e841a3432f111d994e7bd455bb1c50d5p@chr7:77050554..77050601, +
1.04e-147FFCP PHASE1:Hg19::chr7:77050554..77050601,+#_e841a3432f111d994e7bd455bb1c50d5p@chr7:77050554..77050601, +
5.64e-145FFCP PHASE2:Hg19::chr19:18288651..18288682,+#_4916a9b9c0704da6809ebd7b85d81244p5@IFI30
5.64e-145FFCP PHASE1:Hg19::chr19:18288651..18288682,+#_4916a9b9c0704da6809ebd7b85d81244p5@IFI30
4.95e-140FFCP PHASE2:Hg19::chr19:18288828..18288861,+#_4e870d264e07d1512a0c6f103b9d3844p7@IFI30
4.95e-140FFCP PHASE1:Hg19::chr19:18288828..18288861,+#_4e870d264e07d1512a0c6f103b9d3844p7@IFI30
5.06e-140FFCP PHASE2:Hg19::chr5:180242646..180242657,-#_3405d626826116e9d7a2ad94f72e3851p15@MGAT1
5.06e-140FFCP PHASE1:Hg19::chr5:180242646..180242657,-#_3405d626826116e9d7a2ad94f72e3851p15@MGAT1
1.31e-139FFCP PHASE1:Hg19::chr1:161188661..161188679,+#_975dc5c42ca402aa5a8b85edc73f16d7p@chr1:161188661..161188679, +
1.31e-139FFCP PHASE2:Hg19::chr1:161188661..161188679,+#_975dc5c42ca402aa5a8b85edc73f16d7p@chr1:161188661..161188679, +
5.87e-136FFCP PHASE2:Hg19::chr2:38358217..38358244,+#_ac1b976c6aed95772a8b56e4e7465181p1@CYP1B1-AS1
5.87e-136FFCP PHASE1:Hg19::chr2:38358217..38358244,+#_ac1b976c6aed95772a8b56e4e7465181p1@CYP1B1-AS1
5.37e-135FFCP PHASE1:Hg19::chr4:185314125..185314143,-#_b468b272878570395920f3a5fd5b2d3ap@chr4:185314125..185314143, -
5.37e-135FFCP PHASE2:Hg19::chr4:185314125..185314143,-#_b468b272878570395920f3a5fd5b2d3ap@chr4:185314125..185314143, -
3.75e-134FFCP PHASE1:Hg19::chr3:149531627..149531651,+#_49b2d9a7d7054ddb1747f92ab2934413p7@RNF13
3.75e-134FFCP PHASE2:Hg19::chr3:149531627..149531651,+#_49b2d9a7d7054ddb1747f92ab2934413p7@RNF13
6.15e-134FFCP PHASE2:Hg19::chr2:119726719..119726744,+#_dc4daa3781e106c1d0f81085af439047p@chr2:119726719..119726744, +
6.15e-134FFCP PHASE1:Hg19::chr2:119726719..119726744,+#_dc4daa3781e106c1d0f81085af439047p@chr2:119726719..119726744, +
7.41e-134FFCP PHASE2:Hg19::chr1:161187824..161187847,+#_a0022696b9fbe8374086cbdd391e1028p@chr1:161187824..161187847, +
7.41e-134FFCP PHASE1:Hg19::chr1:161187824..161187847,+#_a0022696b9fbe8374086cbdd391e1028p@chr1:161187824..161187847, +
2.24e-133FFCP PHASE2:Hg19::chr17:7482481..7482508,-#_081613de6d26b4a983a0135a61a42d5ep@chr17:7482481..7482508, -
2.24e-133FFCP PHASE1:Hg19::chr17:7482481..7482508,-#_081613de6d26b4a983a0135a61a42d5ep@chr17:7482481..7482508, -
4.55e-133FFCP PHASE1:Hg19::chr19:18286116..18286156,+#_661d2739e36b9cf63f8d0dcfac6a6c65p@chr19:18286116..18286156, +
4.55e-133FFCP PHASE2:Hg19::chr19:18286116..18286156,+#_661d2739e36b9cf63f8d0dcfac6a6c65p@chr19:18286116..18286156, +
1.09e-132FFCP PHASE1:Hg19::chr4:185314151..185314178,-#_07cf5422569fa9c7280df55a0ae98a7fp@chr4:185314151..185314178, -
1.09e-132FFCP PHASE2:Hg19::chr4:185314151..185314178,-#_07cf5422569fa9c7280df55a0ae98a7fp@chr4:185314151..185314178, -
1.13e-132FFCP PHASE2:Hg19::chr5:131280548..131280574,-#_5c2516a21088a63bed730718ab182e46p1@ENST00000425320
1.13e-132FFCP PHASE1:Hg19::chr5:131280548..131280574,-#_5c2516a21088a63bed730718ab182e46p1@ENST00000425320
1.42e-132FFCP PHASE1:Hg19::chr2:145429606..145429658,+#_d1c446d9e222e70e32838b68a7130ae3p@chr2:145429606..145429658, +
1.42e-132FFCP PHASE2:Hg19::chr2:145429606..145429658,+#_d1c446d9e222e70e32838b68a7130ae3p@chr2:145429606..145429658, +
1.21e-131FFCP PHASE2:Hg19::chr19:18288064..18288080,+#_9f4c7048da34267cdafd81c0996cf60ap@chr19:18288064..18288080, +
1.21e-131FFCP PHASE1:Hg19::chr19:18288064..18288080,+#_9f4c7048da34267cdafd81c0996cf60ap@chr19:18288064..18288080, +
2.27e-131FFCP PHASE1:Hg19::chr1:150724282..150724308,-#_5ac5784d98730952a6bd28b477d07974p8@CTSS
2.27e-131FFCP PHASE2:Hg19::chr1:150724282..150724308,-#_5ac5784d98730952a6bd28b477d07974p8@CTSS
2.82e-131FFCP PHASE2:Hg19::chrX:37664331..37664352,+#_84939333c35ee1388737badb2a88e718p@chrX:37664331..37664352, +
2.82e-131FFCP PHASE1:Hg19::chrX:37664331..37664352,+#_84939333c35ee1388737badb2a88e718p@chrX:37664331..37664352, +
4.07e-131FFCP PHASE2:Hg19::chr4:185314188..185314207,-#_e2ee5799beac351b10c0e5af799123d5p@chr4:185314188..185314207, -
4.07e-131FFCP PHASE1:Hg19::chr4:185314188..185314207,-#_e2ee5799beac351b10c0e5af799123d5p@chr4:185314188..185314207, -
5.24e-131FFCP PHASE1:Hg19::chr15:65174546..65174583,-#_3e621801ab04b9722e3928a656c940a4p@chr15:65174546..65174583, -
5.24e-131FFCP PHASE2:Hg19::chr15:65174546..65174583,-#_3e621801ab04b9722e3928a656c940a4p@chr15:65174546..65174583, -
2.76e-130FFCP PHASE1:Hg19::chr4:159727272..159727307,+#_5e3c44e2014780eb1b0c222bb3660ec1p7@FNIP2
2.76e-130FFCP PHASE2:Hg19::chr4:159727272..159727307,+#_5e3c44e2014780eb1b0c222bb3660ec1p7@FNIP2
3.58e-130FFCP PHASE1:Hg19::chr1:161188746..161188758,+#_0a1780f6da603de717a7e850d0ef9eadp@chr1:161188746..161188758, +
3.58e-130FFCP PHASE2:Hg19::chr1:161188746..161188758,+#_0a1780f6da603de717a7e850d0ef9eadp@chr1:161188746..161188758, +
2.17e-129FFCP PHASE2:Hg19::chr20:1517991..1518011,-#_ed73f72f8f6193ea95552dd0f2278128p@chr20:1517991..1518011, -
2.17e-129FFCP PHASE1:Hg19::chr20:1517991..1518011,-#_ed73f72f8f6193ea95552dd0f2278128p@chr20:1517991..1518011, -
3.46e-129FFCP PHASE1:Hg19::chr18:2847062..2847071,+#_3315df1f42f49b07d7a6d14932675cf6p7@EMILIN2
3.46e-129FFCP PHASE2:Hg19::chr18:2847062..2847071,+#_3315df1f42f49b07d7a6d14932675cf6p7@EMILIN2
1.47e-128FFCP PHASE1:Hg19::chr19:18288514..18288554,+#_5cc219cf1e8ebfe46eea88c60102da7cp6@IFI30
1.47e-128FFCP PHASE2:Hg19::chr19:18288514..18288554,+#_5cc219cf1e8ebfe46eea88c60102da7cp6@IFI30
1.78e-128FFCP PHASE1:Hg19::chr19:18288914..18288931,-#_8020898b0d897b8050e9dbe1fcf3f980p5@CU676849, p5@CU689079
1.78e-128FFCP PHASE2:Hg19::chr19:18288914..18288931,-#_8020898b0d897b8050e9dbe1fcf3f980p5@CU676849, p5@CU689079
2.01e-128FFCP PHASE1:Hg19::chr5:180242576..180242585,-#_9dd64fdae37d93929d661a5f9eff1e1dp12@MGAT1
2.01e-128FFCP PHASE2:Hg19::chr5:180242576..180242585,-#_9dd64fdae37d93929d661a5f9eff1e1dp12@MGAT1
2.32e-127FFCP PHASE2:Hg19::chr17:40168698..40168726,-#_3f2620f5c9e56d754afd26e3c4827d02p1@AK126179
2.32e-127FFCP PHASE1:Hg19::chr17:40168698..40168726,-#_3f2620f5c9e56d754afd26e3c4827d02p1@AK126179
2.49e-127FFCP PHASE2:Hg19::chr17:7483714..7483726,+#_c945b31e2eb3132953fb90433bb45ce9p@chr17:7483714..7483726, +
2.49e-127FFCP PHASE1:Hg19::chr17:7483714..7483726,+#_c945b31e2eb3132953fb90433bb45ce9p@chr17:7483714..7483726, +
1.19e-126FFCP PHASE2:Hg19::chr22:46998103..46998127,-#_f7b204f17ca4c68e13f25a4e6ad941dbp@chr22:46998103..46998127, -
1.19e-126FFCP PHASE1:Hg19::chr22:46998103..46998127,-#_f7b204f17ca4c68e13f25a4e6ad941dbp@chr22:46998103..46998127, -
2.16e-126FFCP PHASE1:Hg19::chr19:18285955..18285972,+#_3f71b355ac70ebde7217920f15cce7dep@chr19:18285955..18285972, +
2.16e-126FFCP PHASE2:Hg19::chr19:18285955..18285972,+#_3f71b355ac70ebde7217920f15cce7dep@chr19:18285955..18285972, +
3.83e-126FFCP PHASE1:Hg19::chr19:51625924..51625942,+#_6100f824c480533c174ce83d183b2892p@chr19:51625924..51625942, +
3.83e-126FFCP PHASE2:Hg19::chr19:51625924..51625942,+#_6100f824c480533c174ce83d183b2892p@chr19:51625924..51625942, +
7.27e-126FFCP PHASE1:Hg19::chr4:185266972..185267007,+#_30217061e294eb9814d7f98f97b516a8p@chr4:185266972..185267007, +
7.27e-126FFCP PHASE2:Hg19::chr4:185266972..185267007,+#_30217061e294eb9814d7f98f97b516a8p@chr4:185266972..185267007, +
2.66e-125FFCP PHASE2:Hg19::chrX:152086449..152086473,+#_17870b170cb29e36c8d280277d0c859bp4@ZNF185
2.66e-125FFCP PHASE1:Hg19::chrX:152086449..152086473,+#_17870b170cb29e36c8d280277d0c859bp4@ZNF185
7.73e-125FFCP PHASE1:Hg19::chr2:145276939..145276960,+#_800526383474788672660c5440a0fe92p2@ZEB2-AS1
7.73e-125FFCP PHASE2:Hg19::chr2:145276939..145276960,+#_800526383474788672660c5440a0fe92p2@ZEB2-AS1
8.12e-125FFCP PHASE2:Hg19::chr15:59469817..59469836,+#_26c2162030fbd71556499818047d2916p@chr15:59469817..59469836, +
8.12e-125FFCP PHASE1:Hg19::chr15:59469817..59469836,+#_26c2162030fbd71556499818047d2916p@chr15:59469817..59469836, +
1.56e-124FFCP PHASE2:Hg19::chr20:1517945..1517963,-#_72a3edb409981b3f5d0a998451d887d9p@chr20:1517945..1517963, -
1.56e-124FFCP PHASE1:Hg19::chr20:1517945..1517963,-#_72a3edb409981b3f5d0a998451d887d9p@chr20:1517945..1517963, -
1.65e-124FFCP PHASE2:Hg19::chr8:116588888..116588904,+#_42552d71e39c9a0ac9456dd061a75e56p@chr8:116588888..116588904, +
1.65e-124FFCP PHASE1:Hg19::chr8:116588888..116588904,+#_42552d71e39c9a0ac9456dd061a75e56p@chr8:116588888..116588904, +
1.87e-124FFCP PHASE1:Hg19::chr1:161188686..161188721,+#_6380f99099a7f98468aed618a40c6a21p@chr1:161188686..161188721, +
1.87e-124FFCP PHASE2:Hg19::chr1:161188686..161188721,+#_6380f99099a7f98468aed618a40c6a21p@chr1:161188686..161188721, +
7.08e-124FFCP PHASE1:Hg19::chr5:77845080..77845099,-#_e6f6a9543cf57aed119f7d2df5a96b3bp10@LHFPL2
7.08e-124FFCP PHASE2:Hg19::chr5:77845080..77845099,-#_e6f6a9543cf57aed119f7d2df5a96b3bp10@LHFPL2
1.48e-123FFCP PHASE1:Hg19::chr9:137264970..137264982,+#_bf843d4008f5bf9d6a74bc52d9427fffp@chr9:137264970..137264982, +
1.48e-123FFCP PHASE2:Hg19::chr9:137264970..137264982,+#_bf843d4008f5bf9d6a74bc52d9427fffp@chr9:137264970..137264982, +
6.01e-123FFCP PHASE1:Hg19::chr17:47294661..47294681,+#_92ffb12b3d87f73acb495beb9acb8f64p@chr17:47294661..47294681, +
6.01e-123FFCP PHASE2:Hg19::chr17:47294661..47294681,+#_92ffb12b3d87f73acb495beb9acb8f64p@chr17:47294661..47294681, +
1.14e-122FFCP PHASE1:Hg19::chr1:108593061..108593077,+#_ed234a5288fbfbca21c2f99d62cf14a3p@chr1:108593061..108593077, +
1.14e-122FFCP PHASE2:Hg19::chr1:108593061..108593077,+#_ed234a5288fbfbca21c2f99d62cf14a3p@chr1:108593061..108593077, +
2.07e-122FFCP PHASE2:Hg19::chrX:153286067..153286101,-#_039ebdc09084b301ef30d4ef6e2903cfp@chrX:153286067..153286101, -
2.07e-122FFCP PHASE1:Hg19::chrX:153286067..153286101,-#_039ebdc09084b301ef30d4ef6e2903cfp@chrX:153286067..153286101, -
3.07e-122FFCP PHASE2:Hg19::chr14:103587759..103587770,+#_9856679a3f38884ddca0316db28a22c5p@chr14:103587759..103587770, +
3.07e-122FFCP PHASE1:Hg19::chr14:103587759..103587770,+#_9856679a3f38884ddca0316db28a22c5p@chr14:103587759..103587770, +
7.82e-122FFCP PHASE1:Hg19::chr1:17945095..17945126,+#_003f551dad7de92870eed6c206c9c85ap7@ARHGEF10L
7.82e-122FFCP PHASE2:Hg19::chr1:17945095..17945126,+#_003f551dad7de92870eed6c206c9c85ap7@ARHGEF10L
3.27e-121FFCP PHASE2:Hg19::chr16:50313426..50313459,+#_3ee52232ca68108bb4a2c2b96e1fbcd1p@chr16:50313426..50313459, +
3.27e-121FFCP PHASE1:Hg19::chr16:50313426..50313459,+#_3ee52232ca68108bb4a2c2b96e1fbcd1p@chr16:50313426..50313459, +
3.74e-121FFCP PHASE2:Hg19::chr10:20105868..20105875,+#_0e5a23faf85f7ce6aa9a9ac43c46fecfp8@PLXDC2
3.74e-121FFCP PHASE1:Hg19::chr10:20105868..20105875,+#_0e5a23faf85f7ce6aa9a9ac43c46fecfp8@PLXDC2
7.36e-121FFCP PHASE2:Hg19::chr1:150705526..150705571,-#_cbe6b5dc2466eda566cfcc2f54c2b409p@chr1:150705526..150705571, -
7.36e-121FFCP PHASE1:Hg19::chr1:150705526..150705571,-#_cbe6b5dc2466eda566cfcc2f54c2b409p@chr1:150705526..150705571, -
1.75e-120FFCP PHASE2:Hg19::chr19:18283959..18283993,+#_cb01dc8c4e4d3b6ef42e2c487297fbaep@chr19:18283959..18283993, +
1.75e-120FFCP PHASE1:Hg19::chr19:18283959..18283993,+#_cb01dc8c4e4d3b6ef42e2c487297fbaep@chr19:18283959..18283993, +

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