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Coexpression cluster:C2177

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Full id: C2177_Hepatocyte_testicular_smallcell_thyroid_Smooth_mesenchymal_Fibroblast



Phase1 CAGE Peaks

Hg19::chr12:104337515..104337541,+p3@HSP90B1
Hg19::chr15:99797845..99797875,+p1@HSP90B2P
Hg19::chr15:99798553..99798559,+p2@HSP90B2P
Hg19::chr15:99799810..99799835,+p@chr15:99799810..99799835
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
1.34994904617325e-078.54517746227668e-05211{HSP90B1,11} (Static Module):NA



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0051082unfolded protein binding0.00358663320311547
GO:0006457protein folding0.00534750789630332
GO:0046790virion binding0.0102038813464514
GO:0050750low-density lipoprotein receptor binding0.0113687003422083
GO:0051208sequestering of calcium ion0.0113687003422083
GO:0005783endoplasmic reticulum0.0113687003422083
GO:0051238sequestering of metal ion0.0113687003422083
GO:0006950response to stress0.0168074092660392
GO:0051235maintenance of localization0.027875829922043
GO:0001666response to hypoxia0.0293685782503145
GO:0005788endoplasmic reticulum lumen0.0326240636776248
GO:0048471perinuclear region of cytoplasm0.0326240636776248
GO:0048770pigment granule0.0362549912429353
GO:0042470melanosome0.0362549912429353
GO:0055074calcium ion homeostasis0.0417632496534629
GO:0006874cellular calcium ion homeostasis0.0417632496534629
GO:0006875cellular metal ion homeostasis0.0417632496534629
GO:0055065metal ion homeostasis0.0417632496534629
GO:0005792microsome0.0485848139057113
GO:0042598vesicular fraction0.0485848139057113
GO:0006916anti-apoptosis0.0485848139057113
GO:0030005cellular di-, tri-valent inorganic cation homeostasis0.0485848139057113
GO:0055066di-, tri-valent inorganic cation homeostasis0.0485848139057113
GO:0030003cellular cation homeostasis0.0495684243571312
GO:0055080cation homeostasis0.0495684243571312
GO:0043066negative regulation of apoptosis0.0498633436779434
GO:0043069negative regulation of programmed cell death0.0498633436779434
GO:0055082cellular chemical homeostasis0.0498633436779434
GO:0006873cellular ion homeostasis0.0498633436779434



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
reproductive structure6.70e-0859
reproductive system6.70e-0859
Disease
Ontology termp-valuen
disease of cellular proliferation5.94e-17239
cancer4.51e-16235
cell type cancer2.17e-10143
carcinoma5.45e-09106
reproductive organ cancer2.05e-0829
ovarian cancer3.65e-0814
female reproductive organ cancer5.14e-0827


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.11.47051
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.11.6149
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.12.4958
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.98779
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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