Novel motif:145

name:	motif145_GMAGWCGMAW

Association to promoter expression in human samples<b>Summary:</b>Significance of the correlation with CAGE expression, human <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

---

Association to promoter expression in mouse samples <b>Summary:</b>Significance of the correlation with CAGE expression, mouse <br><b>Analyst:</b> Michiel de Hoon<br><br>link to source dataset <br>data

---

GREAT analysis results for human <b>Summary:</b>Genomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon<br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0045650	negative regulation of macrophage differentiation	1.439800e-13
GO:0045649	regulation of macrophage differentiation	4.990777e-13
GO:0090304	nucleic acid metabolic process	1.060679e-10
GO:0044260	cellular macromolecule metabolic process	1.207293e-9
GO:0034645	cellular macromolecule biosynthetic process	2.557040e-9
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	2.621969e-9
GO:0010467	gene expression	3.316747e-9
GO:0009059	macromolecule biosynthetic process	3.782931e-9
GO:0002762	negative regulation of myeloid leukocyte differentiation	4.050155e-9
GO:0019230	proprioception	1.039052e-8
GO:0071248	cellular response to metal ion	1.307857e-8
GO:0001893	maternal placenta development	1.572071e-8
GO:0035845	photoreceptor cell outer segment organization	2.045224e-8
GO:0071281	cellular response to iron ion	3.324059e-8
GO:0006413	translational initiation	4.208726e-8
GO:0046548	retinal rod cell development	4.451355e-8
GO:0006139	nucleobase-containing compound metabolic process	5.712232e-8
GO:0016070	RNA metabolic process	5.923588e-8
GO:0043170	macromolecule metabolic process	6.229991e-8
GO:0071277	cellular response to calcium ion	2.332570e-7
GO:0035458	cellular response to interferon-beta	2.342971e-7
GO:0043004	cytoplasmic sequestering of CFTR protein	4.692457e-7
GO:0009107	lipoate biosynthetic process	7.090703e-7
GO:0034389	lipid particle organization	9.272866e-7
GO:0051355	proprioception involved in equilibrioception	9.503430e-7
GO:0000086	G2/M transition of mitotic cell cycle	1.012516e-6
GO:0034641	cellular nitrogen compound metabolic process	1.202887e-6
GO:0016339	calcium-dependent cell-cell adhesion	1.707060e-6
GO:0006807	nitrogen compound metabolic process	2.262653e-6
GO:0044237	cellular metabolic process	2.508743e-6
GO:0072657	protein localization in membrane	2.769469e-6
GO:0046022	positive regulation of transcription from RNA polymerase II promoter during mitosis	2.824690e-6
GO:0032042	mitochondrial DNA metabolic process	3.152426e-6
GO:0032908	regulation of transforming growth factor beta1 production	3.162198e-6
GO:0002688	regulation of leukocyte chemotaxis	3.358693e-6
GO:0032914	positive regulation of transforming growth factor beta1 production	3.485276e-6
GO:0010966	regulation of phosphate transport	3.511482e-6
GO:0009266	response to temperature stimulus	3.607957e-6
GO:0032774	RNA biosynthetic process	3.671748e-6
GO:0000416	positive regulation of histone H3-K36 methylation	3.923609e-6
GO:0035928	rRNA import into mitochondrion	3.997885e-6
GO:0051041	positive regulation of calcium-independent cell-cell adhesion	4.683551e-6
GO:0050902	leukocyte adhesive activation	4.683551e-6
GO:0010890	positive regulation of sequestering of triglyceride	4.785983e-6
GO:0071241	cellular response to inorganic substance	5.461422e-6
GO:0045792	negative regulation of cell size	5.783433e-6
GO:0031334	positive regulation of protein complex assembly	5.937551e-6
GO:0021623	oculomotor nerve formation	6.688145e-6
GO:0003409	optic cup structural organization	6.688145e-6
GO:0003404	optic vesicle morphogenesis	6.688145e-6
GO:0071634	regulation of transforming growth factor beta production	7.275934e-6
GO:0002502	peptide antigen assembly with MHC class I protein complex	7.547776e-6
GO:0048266	behavioral response to pain	8.666519e-6
GO:0000226	microtubule cytoskeleton organization	8.896469e-6
GO:0045766	positive regulation of angiogenesis	8.969262e-6
GO:0032570	response to progesterone stimulus	9.143512e-6
GO:0032006	regulation of TOR signaling cascade	9.465392e-6
GO:0048333	mesodermal cell differentiation	9.595990e-6
GO:2000620	positive regulation of histone H4-K16 acetylation	9.631457e-6
GO:0070512	positive regulation of histone H4-K20 methylation	9.631457e-6
GO:2000617	positive regulation of histone H3-K9 acetylation	9.631457e-6
GO:0009987	cellular process	9.850994e-6
GO:0006467	protein thiol-disulfide exchange	1.011142e-5
GO:0071675	regulation of mononuclear cell migration	1.093396e-5
GO:0042508	tyrosine phosphorylation of Stat1 protein	1.211479e-5
GO:0006412	translation	1.656735e-5
GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	1.709848e-5
GO:0042506	tyrosine phosphorylation of Stat5 protein	1.720890e-5
GO:0008152	metabolic process	1.727571e-5
GO:0051029	rRNA transport	1.728549e-5
GO:0000002	mitochondrial genome maintenance	1.797267e-5
GO:0006351	transcription, DNA-dependent	1.804219e-5
GO:0030431	sleep	1.819015e-5
GO:0002690	positive regulation of leukocyte chemotaxis	1.822587e-5
GO:0010758	regulation of macrophage chemotaxis	1.949278e-5
GO:0032007	negative regulation of TOR signaling cascade	1.950442e-5
GO:0009408	response to heat	1.987416e-5
GO:0071800	podosome assembly	2.143925e-5
GO:0010842	retina layer formation	2.149077e-5
GO:0045835	negative regulation of meiosis	2.363117e-5
GO:0002687	positive regulation of leukocyte migration	2.405641e-5
GO:0048265	response to pain	2.420875e-5
GO:0021513	spinal cord dorsal/ventral patterning	2.640771e-5
GO:0032069	regulation of nuclease activity	2.665339e-5
GO:0009048	dosage compensation, by inactivation of X chromosome	2.773310e-5
GO:0045176	apical protein localization	2.954878e-5
GO:0001710	mesodermal cell fate commitment	3.056214e-5
GO:0043271	negative regulation of ion transport	3.375318e-5
GO:0035050	embryonic heart tube development	3.582709e-5
GO:0030704	vitelline membrane formation	3.801485e-5
GO:0010459	negative regulation of heart rate	4.071390e-5
GO:0048665	neuron fate specification	4.372545e-5
GO:0071423	malate transmembrane transport	4.392772e-5
GO:0015709	thiosulfate transport	4.392772e-5
GO:0006401	RNA catabolic process	4.429411e-5
GO:0035456	response to interferon-beta	4.976433e-5
GO:0010759	positive regulation of macrophage chemotaxis	5.046866e-5
GO:0060215	primitive hemopoiesis	5.440109e-5
GO:0010746	regulation of plasma membrane long-chain fatty acid transport	5.558345e-5
GO:0046330	positive regulation of JNK cascade	5.588291e-5
GO:0046697	decidualization	5.935015e-5
GO:0071622	regulation of granulocyte chemotaxis	6.318078e-5
GO:0002685	regulation of leukocyte migration	6.431170e-5
GO:0032472	Golgi calcium ion transport	6.548983e-5
GO:0030026	cellular manganese ion homeostasis	6.548983e-5
GO:0032468	Golgi calcium ion homeostasis	6.548983e-5
GO:0035803	egg coat formation	6.687251e-5
GO:0071636	positive regulation of transforming growth factor beta production	6.735817e-5
GO:0035690	cellular response to drug	6.764316e-5
GO:0010889	regulation of sequestering of triglyceride	6.839961e-5
GO:0061113	pancreas morphogenesis	7.043825e-5
GO:0010509	polyamine homeostasis	7.043825e-5
GO:0060816	random inactivation of X chromosome	7.043825e-5
GO:0090224	regulation of spindle organization	7.151913e-5
GO:0001661	conditioned taste aversion	7.161877e-5
GO:0060081	membrane hyperpolarization	7.677661e-5
GO:0035095	behavioral response to nicotine	8.030643e-5
GO:0006457	protein folding	8.513046e-5
GO:0060807	regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification	9.106555e-5
GO:0003142	cardiogenic plate morphogenesis	9.106555e-5
GO:0021559	trigeminal nerve development	9.369521e-5
GO:0051926	negative regulation of calcium ion transport	9.613893e-5
GO:0033555	multicellular organismal response to stress	1.004432e-4
GO:0007009	plasma membrane organization	1.058462e-4
GO:0046320	regulation of fatty acid oxidation	1.127002e-4
GO:0072298	regulation of metanephric glomerulus development	1.147495e-4
GO:0072215	regulation of metanephros development	1.150093e-4
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	1.159650e-4
GO:0048515	spermatid differentiation	1.162629e-4
GO:0007286	spermatid development	1.188601e-4
GO:0072659	protein localization in plasma membrane	1.218559e-4
GO:0021511	spinal cord patterning	1.242500e-4
GO:0090086	negative regulation of protein deubiquitination	1.243842e-4
GO:0044238	primary metabolic process	1.260756e-4
GO:0021514	ventral spinal cord interneuron differentiation	1.305016e-4
GO:0009223	pyrimidine deoxyribonucleotide catabolic process	1.320179e-4
GO:0007019	microtubule depolymerization	1.320179e-4
GO:0033687	osteoblast proliferation	1.415062e-4
GO:0071396	cellular response to lipid	1.465613e-4
GO:0006646	phosphatidylethanolamine biosynthetic process	1.571602e-4
GO:0090003	regulation of establishment of protein localization in plasma membrane	1.572039e-4
GO:0051385	response to mineralocorticoid stimulus	1.581110e-4
GO:0030968	endoplasmic reticulum unfolded protein response	1.600330e-4
GO:0090234	regulation of kinetochore assembly	1.682491e-4
GO:0090169	regulation of spindle assembly	1.682491e-4
GO:0009106	lipoate metabolic process	1.717715e-4
GO:0061029	eyelid development in camera-type eye	1.740112e-4
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	1.777825e-4
GO:0051412	response to corticosterone stimulus	1.783429e-4
GO:0045060	negative thymic T cell selection	1.788593e-4
GO:0009744	response to sucrose stimulus	1.821621e-4
GO:0043267	negative regulation of potassium ion transport	1.870272e-4
GO:0022403	cell cycle phase	1.880016e-4
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport	1.890329e-4
GO:0032886	regulation of microtubule-based process	1.890541e-4
GO:0021506	anterior neuropore closure	1.915086e-4
GO:0045638	negative regulation of myeloid cell differentiation	1.922255e-4
GO:0060579	ventral spinal cord interneuron fate commitment	1.923966e-4
GO:0030838	positive regulation of actin filament polymerization	1.944289e-4
GO:0060911	cardiac cell fate commitment	2.007251e-4
GO:0021603	cranial nerve formation	2.007251e-4
GO:0071469	cellular response to alkalinity	2.008501e-4
GO:0060623	regulation of chromosome condensation	2.008501e-4
GO:0071283	cellular response to iron(III) ion	2.008501e-4
GO:0046680	response to DDT	2.008501e-4
GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	2.008501e-4
GO:0032273	positive regulation of protein polymerization	2.025453e-4
GO:0090004	positive regulation of establishment of protein localization in plasma membrane	2.103502e-4
GO:0034614	cellular response to reactive oxygen species	2.171257e-4
GO:0043383	negative T cell selection	2.181171e-4
GO:0044265	cellular macromolecule catabolic process	2.186213e-4
GO:0001970	positive regulation of activation of membrane attack complex	2.193142e-4
GO:0006984	ER-nucleus signaling pathway	2.206477e-4
GO:0045654	positive regulation of megakaryocyte differentiation	2.262029e-4
GO:0006264	mitochondrial DNA replication	2.337234e-4
GO:0015827	tryptophan transport	2.337234e-4
GO:0044249	cellular biosynthetic process	2.343207e-4
GO:0060322	head development	2.344813e-4
GO:0060348	bone development	2.438435e-4
GO:0007530	sex determination	2.482895e-4
GO:0034599	cellular response to oxidative stress	2.495633e-4
GO:0046549	retinal cone cell development	2.505385e-4
GO:0014821	phasic smooth muscle contraction	2.526566e-4
GO:0001654	eye development	2.590403e-4
GO:0048075	positive regulation of eye pigmentation	2.627898e-4
GO:0061157	mRNA destabilization	2.653285e-4
GO:0010609	posttranscriptional regulation of gene expression by mRNA localization	2.653285e-4
GO:0006346	methylation-dependent chromatin silencing	2.857013e-4
GO:0031346	positive regulation of cell projection organization	2.871516e-4
GO:0000921	septin ring assembly	2.936580e-4
GO:0002072	optic cup morphogenesis involved in camera-type eye development	2.958571e-4
GO:0021517	ventral spinal cord development	2.977687e-4
GO:0010039	response to iron ion	2.994694e-4
GO:0043010	camera-type eye development	3.016579e-4
GO:0015801	aromatic amino acid transport	3.071361e-4
GO:0060795	cell fate commitment involved in formation of primary germ layers	3.075626e-4
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	3.253060e-4
GO:0070507	regulation of microtubule cytoskeleton organization	3.260633e-4
GO:0030220	platelet formation	3.294738e-4
GO:0051645	Golgi localization	3.602022e-4
GO:0042503	tyrosine phosphorylation of Stat3 protein	3.625901e-4
GO:0002455	humoral immune response mediated by circulating immunoglobulin	3.718879e-4
GO:0001708	cell fate specification	3.814133e-4
GO:0006939	smooth muscle contraction	3.834524e-4
GO:0009231	riboflavin biosynthetic process	3.885186e-4
GO:0060324	face development	3.925979e-4
GO:0030099	myeloid cell differentiation	3.934182e-4
GO:0051238	sequestering of metal ion	4.039239e-4
GO:0060026	convergent extension	4.046288e-4
GO:0007098	centrosome cycle	4.216584e-4
GO:0032075	positive regulation of nuclease activity	4.423482e-4
GO:0030218	erythrocyte differentiation	4.481897e-4
GO:0006208	pyrimidine base catabolic process	4.486459e-4
GO:0042461	photoreceptor cell development	4.580885e-4
GO:0048645	organ formation	4.643819e-4
GO:0072070	loop of Henle development	4.693916e-4
GO:0042345	regulation of NF-kappaB import into nucleus	4.695233e-4
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	4.707409e-4
GO:0051983	regulation of chromosome segregation	4.747818e-4
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	4.769633e-4
GO:2000615	regulation of histone H3-K9 acetylation	4.778220e-4
GO:0060279	positive regulation of ovulation	4.897560e-4
GO:0042541	hemoglobin biosynthetic process	4.916647e-4
GO:0032757	positive regulation of interleukin-8 production	4.916700e-4
GO:0051293	establishment of spindle localization	4.952357e-4
GO:0090129	positive regulation of synapse maturation	4.969523e-4
GO:0030224	monocyte differentiation	5.030106e-4
GO:0051984	positive regulation of chromosome segregation	5.032074e-4
GO:0048872	homeostasis of number of cells	5.079739e-4
GO:0006244	pyrimidine nucleotide catabolic process	5.143317e-4
GO:0021854	hypothalamus development	5.177487e-4
GO:0046113	nucleobase catabolic process	5.197146e-4
GO:0070172	positive regulation of tooth mineralization	5.305292e-4
GO:0045652	regulation of megakaryocyte differentiation	5.519427e-4
GO:0044087	regulation of cellular component biogenesis	5.554373e-4
GO:0003334	keratinocyte development	5.618978e-4
GO:0010824	regulation of centrosome duplication	5.641297e-4
GO:0006893	Golgi to plasma membrane transport	5.644837e-4
GO:0045765	regulation of angiogenesis	5.645751e-4
GO:0006355	regulation of transcription, DNA-dependent	5.685526e-4
GO:0006310	DNA recombination	5.724935e-4
GO:0032695	negative regulation of interleukin-12 production	5.980704e-4
GO:0035051	cardiac cell differentiation	6.084000e-4
GO:0060914	heart formation	6.085137e-4
GO:0043254	regulation of protein complex assembly	6.095068e-4
GO:0030853	negative regulation of granulocyte differentiation	6.111908e-4
GO:0035356	cellular triglyceride homeostasis	6.282273e-4
GO:0010575	positive regulation vascular endothelial growth factor production	6.286279e-4
GO:0006824	cobalt ion transport	6.399185e-4
GO:0030194	positive regulation of blood coagulation	6.513688e-4
GO:0060706	cell differentiation involved in embryonic placenta development	6.514105e-4
GO:0016331	morphogenesis of embryonic epithelium	6.520632e-4
GO:0046605	regulation of centrosome cycle	6.599948e-4
GO:0046599	regulation of centriole replication	6.737865e-4
GO:0042462	eye photoreceptor cell development	6.853132e-4
GO:0001841	neural tube formation	6.991029e-4
GO:0000301	retrograde transport, vesicle recycling within Golgi	7.069184e-4
GO:2000112	regulation of cellular macromolecule biosynthetic process	7.107528e-4
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	7.139240e-4
GO:0000414	regulation of histone H3-K36 methylation	7.228545e-4
GO:0071374	cellular response to parathyroid hormone stimulus	7.336581e-4
GO:0072086	specification of loop of Henle identity	7.393850e-4
GO:0002577	regulation of antigen processing and presentation	7.478833e-4
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	7.483645e-4
GO:0033563	dorsal/ventral axon guidance	7.483645e-4
GO:0003407	neural retina development	7.495471e-4
GO:0006228	UTP biosynthetic process	7.502182e-4
GO:0006183	GTP biosynthetic process	7.502182e-4
GO:0006165	nucleoside diphosphate phosphorylation	7.502182e-4
GO:0022402	cell cycle process	7.542821e-4
GO:0002639	positive regulation of immunoglobulin production	7.569702e-4
GO:0060080	regulation of inhibitory postsynaptic membrane potential	7.590753e-4
GO:0042727	flavin-containing compound biosynthetic process	7.648061e-4
GO:0031119	tRNA pseudouridine synthesis	7.759168e-4
GO:0008616	queuosine biosynthetic process	7.759168e-4
GO:0001947	heart looping	7.770633e-4
GO:0030433	ER-associated protein catabolic process	7.836759e-4
GO:0097114	N-methyl-D-aspartate receptor clustering	7.853155e-4
GO:0097117	guanylate kinase-associated protein clustering	7.853155e-4
GO:0097112	gamma-aminobutyric acid receptor clustering	7.853155e-4
GO:0051208	sequestering of calcium ion	7.853155e-4
GO:0032677	regulation of interleukin-8 production	7.870461e-4
GO:0033762	response to glucagon stimulus	7.889311e-4
GO:0035967	cellular response to topologically incorrect protein	7.953553e-4
GO:0071397	cellular response to cholesterol	8.041455e-4
GO:0010722	regulation of ferrochelatase activity	8.138537e-4
GO:0001878	response to yeast	8.273090e-4
GO:0046836	glycolipid transport	8.425701e-4
GO:0035313	wound healing, spreading of epidermal cells	8.536688e-4
GO:0008105	asymmetric protein localization	8.536688e-4
GO:0090084	negative regulation of inclusion body assembly	8.692423e-4
GO:0070584	mitochondrion morphogenesis	8.692423e-4
GO:0071398	cellular response to fatty acid	8.765824e-4
GO:0030827	negative regulation of cGMP biosynthetic process	9.112320e-4
GO:0060913	cardiac cell fate determination	9.117221e-4
GO:0090128	regulation of synapse maturation	9.164247e-4
GO:2000627	positive regulation of miRNA catabolic process	9.257778e-4
GO:0000964	mitochondrial RNA 5'-end processing	9.257778e-4
GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	9.257778e-4
GO:0007017	microtubule-based process	9.613080e-4
GO:0052572	response to host immune response	9.725170e-4
GO:0034976	response to endoplasmic reticulum stress	9.797143e-4
GO:0000042	protein targeting to Golgi	1.009554e-3
GO:0043652	engulfment of apoptotic cell	1.026363e-3
GO:0010754	negative regulation of cGMP-mediated signaling	1.026363e-3
GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	1.026363e-3
GO:0002605	negative regulation of dendritic cell antigen processing and presentation	1.026363e-3
GO:0010751	negative regulation of nitric oxide mediated signal transduction	1.026363e-3
GO:0060708	spongiotrophoblast differentiation	1.034601e-3
GO:0048073	regulation of eye pigmentation	1.040200e-3
GO:0043241	protein complex disassembly	1.040266e-3
GO:0060038	cardiac muscle cell proliferation	1.044842e-3
GO:0048193	Golgi vesicle transport	1.079071e-3
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	1.135330e-3
GO:0071425	hemopoietic stem cell proliferation	1.135767e-3
GO:0031054	pre-miRNA processing	1.143737e-3
GO:0051661	maintenance of centrosome location	1.145394e-3
GO:0060349	bone morphogenesis	1.186818e-3
GO:0042346	positive regulation of NF-kappaB import into nucleus	1.237608e-3
GO:0023041	neuronal signal transduction	1.286559e-3
GO:0097105	presynaptic membrane assembly	1.286756e-3
GO:0000278	mitotic cell cycle	1.288427e-3
GO:0061077	chaperone-mediated protein folding	1.334545e-3
GO:0006879	cellular iron ion homeostasis	1.361771e-3
GO:0006958	complement activation, classical pathway	1.371306e-3
GO:0006359	regulation of transcription from RNA polymerase III promoter	1.372683e-3
GO:0072272	proximal/distal pattern formation involved in metanephric nephron development	1.373877e-3
GO:0046600	negative regulation of centriole replication	1.381024e-3
GO:0019061	uncoating of virus	1.449704e-3
GO:0070407	oxidation-dependent protein catabolic process	1.449704e-3
GO:0016095	polyprenol catabolic process	1.449704e-3
GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure	1.449704e-3
GO:0072600	establishment of protein localization in Golgi	1.464543e-3
GO:0006657	CDP-choline pathway	1.517713e-3
GO:0061014	positive regulation of mRNA catabolic process	1.549359e-3
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	1.581554e-3
GO:0048520	positive regulation of behavior	1.591027e-3
GO:0014020	primary neural tube formation	1.603106e-3
GO:0009132	nucleoside diphosphate metabolic process	1.616462e-3
GO:0006198	cAMP catabolic process	1.624204e-3
GO:0043148	mitotic spindle stabilization	1.630574e-3
GO:0002344	B cell affinity maturation	1.630574e-3
GO:0032722	positive regulation of chemokine production	1.651031e-3
GO:0046326	positive regulation of glucose import	1.653279e-3
GO:0051895	negative regulation of focal adhesion assembly	1.657302e-3
GO:0043525	positive regulation of neuron apoptosis	1.667905e-3
GO:0046888	negative regulation of hormone secretion	1.673016e-3
GO:0048246	macrophage chemotaxis	1.696389e-3
GO:0001974	blood vessel remodeling	1.706864e-3
GO:2000191	regulation of fatty acid transport	1.725714e-3
GO:0071422	succinate transmembrane transport	1.790534e-3
GO:0051130	positive regulation of cellular component organization	1.865276e-3
GO:0001843	neural tube closure	1.884551e-3
GO:0008045	motor axon guidance	1.920330e-3
GO:0043457	regulation of cellular respiration	1.977281e-3
GO:0009186	deoxyribonucleoside diphosphate metabolic process	1.977281e-3
GO:0001886	endothelial cell morphogenesis	2.088771e-3
GO:0006241	CTP biosynthetic process	2.114014e-3
GO:0000041	transition metal ion transport	2.130199e-3
GO:0045665	negative regulation of neuron differentiation	2.150417e-3
GO:0050820	positive regulation of coagulation	2.154084e-3
GO:0020027	hemoglobin metabolic process	2.161139e-3
GO:0032891	negative regulation of organic acid transport	2.170684e-3
GO:0043624	cellular protein complex disassembly	2.231553e-3
GO:0050968	detection of chemical stimulus involved in sensory perception of pain	2.251140e-3
GO:0031023	microtubule organizing center organization	2.256016e-3
GO:0060017	parathyroid gland development	2.274585e-3
GO:0042726	flavin-containing compound metabolic process	2.296290e-3
GO:0030199	collagen fibril organization	2.326207e-3
GO:0016926	protein desumoylation	2.348807e-3
GO:0090085	regulation of protein deubiquitination	2.378569e-3
GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation	2.378569e-3
GO:0043461	proton-transporting ATP synthase complex assembly	2.378569e-3
GO:0060606	tube closure	2.407473e-3
GO:0051297	centrosome organization	2.426289e-3
GO:0006119	oxidative phosphorylation	2.433089e-3
GO:0001958	endochondral ossification	2.444436e-3
GO:0034346	positive regulation of type III interferon production	2.472008e-3
GO:0046541	saliva secretion	2.472008e-3
GO:0051571	positive regulation of histone H3-K4 methylation	2.474001e-3
GO:0030046	parallel actin filament bundle assembly	2.476256e-3
GO:0042662	negative regulation of mesodermal cell fate specification	2.502066e-3
GO:0019217	regulation of fatty acid metabolic process	2.530013e-3
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	2.534941e-3
GO:0009058	biosynthetic process	2.537245e-3
GO:0001798	positive regulation of type IIa hypersensitivity	2.550090e-3
GO:0032642	regulation of chemokine production	2.568797e-3
GO:0070170	regulation of tooth mineralization	2.577758e-3
GO:0031326	regulation of cellular biosynthetic process	2.593940e-3
GO:0060337	type I interferon-mediated signaling pathway	2.668888e-3
GO:0070301	cellular response to hydrogen peroxide	2.668888e-3
GO:0034067	protein localization in Golgi apparatus	2.713632e-3
GO:0048343	paraxial mesodermal cell fate commitment	2.813558e-3
GO:0071107	response to parathyroid hormone stimulus	2.917215e-3
GO:0009057	macromolecule catabolic process	2.918809e-3
GO:0045080	positive regulation of chemokine biosynthetic process	2.922368e-3
GO:0009792	embryo development ending in birth or egg hatching	2.936778e-3
GO:0055017	cardiac muscle tissue growth	2.939602e-3
GO:0060042	retina morphogenesis in camera-type eye	3.004396e-3
GO:0001885	endothelial cell development	3.011015e-3
GO:0051799	negative regulation of hair follicle development	3.014205e-3
GO:0051964	negative regulation of synapse assembly	3.058589e-3
GO:0045073	regulation of chemokine biosynthetic process	3.098635e-3
GO:0034340	response to type I interferon	3.101569e-3
GO:0050803	regulation of synapse structure and activity	3.184562e-3
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	3.185494e-3
GO:0001771	immunological synapse formation	3.214527e-3
GO:0071482	cellular response to light stimulus	3.230529e-3
GO:0033211	adiponectin-mediated signaling pathway	3.265422e-3
GO:0051329	interphase of mitotic cell cycle	3.299726e-3
GO:0072376	protein activation cascade	3.340061e-3
GO:0090161	Golgi ribbon formation	3.364005e-3
GO:0090230	regulation of centromere complex assembly	3.364005e-3
GO:0045061	thymic T cell selection	3.375960e-3
GO:0010757	negative regulation of plasminogen activation	3.380426e-3
GO:0006051	N-acetylmannosamine metabolic process	3.433713e-3
GO:0071110	histone biotinylation	3.433713e-3
GO:0048592	eye morphogenesis	3.459539e-3
GO:0051445	regulation of meiotic cell cycle	3.479647e-3
GO:0051325	interphase	3.610110e-3
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	3.620467e-3
GO:0008057	eye pigment granule organization	3.620621e-3
GO:0051958	methotrexate transport	3.645353e-3
GO:0014740	negative regulation of muscle hyperplasia	3.645353e-3
GO:0045010	actin nucleation	3.645353e-3
GO:0071625	vocalization behavior	3.646149e-3
GO:0015884	folic acid transport	3.646149e-3
GO:0001819	positive regulation of cytokine production	3.665920e-3
GO:0051261	protein depolymerization	3.678346e-3
GO:0021521	ventral spinal cord interneuron specification	3.712868e-3
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	3.769292e-3
GO:0050951	sensory perception of temperature stimulus	3.771316e-3
GO:0007281	germ cell development	3.804237e-3
GO:0030318	melanocyte differentiation	3.811947e-3
GO:0030206	chondroitin sulfate biosynthetic process	3.829419e-3
GO:0003306	Wnt receptor signaling pathway involved in heart development	3.859491e-3
GO:0000958	mitochondrial mRNA catabolic process	3.867497e-3
GO:0000965	mitochondrial RNA 3'-end processing	3.867497e-3
GO:0043633	polyadenylation-dependent RNA catabolic process	3.867497e-3
GO:0000962	positive regulation of mitochondrial RNA catabolic process	3.867497e-3
GO:0034101	erythrocyte homeostasis	3.937457e-3
GO:0008588	release of cytoplasmic sequestered NF-kappaB	4.000144e-3
GO:0060419	heart growth	4.013408e-3
GO:0006506	GPI anchor biosynthetic process	4.025140e-3
GO:0050873	brown fat cell differentiation	4.035105e-3
GO:0071850	mitotic cell cycle arrest	4.052256e-3
GO:0015942	formate metabolic process	4.121857e-3
GO:0032874	positive regulation of stress-activated MAPK cascade	4.167888e-3
GO:0007163	establishment or maintenance of cell polarity	4.177880e-3
GO:0021515	cell differentiation in spinal cord	4.193786e-3
GO:0006501	C-terminal protein lipidation	4.199068e-3
GO:0019369	arachidonic acid metabolic process	4.210961e-3
GO:0032185	septin cytoskeleton organization	4.217040e-3
GO:0097091	synaptic vesicle clustering	4.230944e-3
GO:0014826	vein smooth muscle contraction	4.244906e-3
GO:0042921	glucocorticoid receptor signaling pathway	4.245726e-3
GO:0050955	thermoception	4.304001e-3
GO:0006882	cellular zinc ion homeostasis	4.317299e-3
GO:0031442	positive regulation of mRNA 3'-end processing	4.317299e-3
GO:0006259	DNA metabolic process	4.371490e-3
GO:0040020	regulation of meiosis	4.390513e-3
GO:0009889	regulation of biosynthetic process	4.437676e-3
GO:0061072	iris morphogenesis	4.438661e-3
GO:0071407	cellular response to organic cyclic compound	4.453311e-3
GO:0060580	ventral spinal cord interneuron fate determination	4.462651e-3
GO:0003327	type B pancreatic cell fate commitment	4.462651e-3
GO:0051968	positive regulation of synaptic transmission, glutamatergic	4.479316e-3
GO:0030889	negative regulation of B cell proliferation	4.511446e-3
GO:0002604	regulation of dendritic cell antigen processing and presentation	4.547010e-3
GO:0010556	regulation of macromolecule biosynthetic process	4.558042e-3
GO:0090096	positive regulation of metanephric cap mesenchymal cell proliferation	4.562549e-3
GO:0070613	regulation of protein processing	4.584061e-3
GO:0002669	positive regulation of T cell anergy	4.622508e-3
GO:0002679	respiratory burst involved in defense response	4.625031e-3
GO:0048048	embryonic eye morphogenesis	4.642707e-3
GO:0046882	negative regulation of follicle-stimulating hormone secretion	4.654785e-3
GO:0001953	negative regulation of cell-matrix adhesion	4.681174e-3
GO:0034199	activation of protein kinase A activity	4.720730e-3
GO:0085029	extracellular matrix assembly	4.727535e-3
GO:0000236	mitotic prometaphase	4.752661e-3
GO:0031076	embryonic camera-type eye development	4.754753e-3
GO:0002675	positive regulation of acute inflammatory response	4.843560e-3
GO:0050850	positive regulation of calcium-mediated signaling	4.886061e-3
GO:0071544	diphosphoinositol polyphosphate catabolic process	4.898965e-3
GO:0002457	T cell antigen processing and presentation	4.898965e-3
GO:0010477	response to sulfur dioxide	4.898965e-3
GO:0060562	epithelial tube morphogenesis	4.948683e-3
GO:2000106	regulation of leukocyte apoptosis	4.994466e-3
GO:0060078	regulation of postsynaptic membrane potential	4.994466e-3
GO:0008298	intracellular mRNA localization	5.042841e-3
GO:0032680	regulation of tumor necrosis factor production	5.050510e-3
GO:0046784	intronless viral mRNA export from host nucleus	5.085176e-3
GO:0043032	positive regulation of macrophage activation	5.098964e-3
GO:0002339	B cell selection	5.127148e-3
GO:0051647	nucleus localization	5.129550e-3
GO:0035115	embryonic forelimb morphogenesis	5.165563e-3
GO:0002544	chronic inflammatory response	5.165563e-3
GO:0044319	wound healing, spreading of cells	5.202275e-3
GO:0018283	iron incorporation into metallo-sulfur cluster	5.202523e-3
GO:0000715	nucleotide-excision repair, DNA damage recognition	5.202523e-3

GREAT analysis results for mouseGenomic Enrichment of Annotations Tool (GREAT, Nat Biotechnol. 2010 May;28(5):495-501) is used to identify, both in human and in mouse, the gene ontology terms of biological processes enriched given the predicted TFBSs, and evaluated the overlap in the top-500 gene ontology terms between human and mouse. For each novel motif, the P value for the overlap was then evaluated by calculating its relative rank with respect to this background distribution.<br>Analyst: Michiel de Hoon <br><br>link to source dataset <br>data

---

GO ID	GO Term	p-value
GO:0090086	negative regulation of protein deubiquitination	2.182043e-12
GO:0090084	negative regulation of inclusion body assembly	2.214592e-10
GO:0010984	regulation of lipoprotein particle clearance	2.375400e-9
GO:0010982	regulation of high-density lipoprotein particle clearance	2.539482e-9
GO:0090085	regulation of protein deubiquitination	3.104183e-9
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	3.521650e-8
GO:0010985	negative regulation of lipoprotein particle clearance	4.509989e-8
GO:0034377	plasma lipoprotein particle assembly	1.170030e-7
GO:0010987	negative regulation of high-density lipoprotein particle clearance	1.400963e-7
GO:0010897	negative regulation of triglyceride catabolic process	1.400963e-7
GO:0051005	negative regulation of lipoprotein lipase activity	3.029311e-7
GO:0034382	chylomicron remnant clearance	3.029311e-7
GO:0010989	negative regulation of low-density lipoprotein particle clearance	4.104984e-7
GO:0070842	aggresome assembly	4.903311e-7
GO:0048261	negative regulation of receptor-mediated endocytosis	1.011957e-6
GO:0090083	regulation of inclusion body assembly	1.377807e-6
GO:0006139	nucleobase-containing compound metabolic process	1.439584e-6
GO:0032488	Cdc42 protein signal transduction	1.476505e-6
GO:0060192	negative regulation of lipase activity	2.064506e-6
GO:0006297	nucleotide-excision repair, DNA gap filling	2.633198e-6
GO:0033205	cell cycle cytokinesis	2.950345e-6
GO:0016074	snoRNA metabolic process	3.026623e-6
GO:0060621	negative regulation of cholesterol import	3.036437e-6
GO:0034551	mitochondrial respiratory chain complex III assembly	3.237563e-6
GO:0003207	cardiac chamber formation	3.332051e-6
GO:0050707	regulation of cytokine secretion	3.547202e-6
GO:0032365	intracellular lipid transport	3.971354e-6
GO:0003211	cardiac ventricle formation	4.282286e-6
GO:0033373	maintenance of protease location in mast cell secretory granule	4.808156e-6
GO:0033382	maintenance of granzyme B location in T cell secretory granule	4.808156e-6
GO:0090362	positive regulation of platelet-derived growth factor production	6.140789e-6
GO:0090336	positive regulation of brown fat cell differentiation	6.140789e-6
GO:0090271	positive regulation of fibroblast growth factor production	6.140789e-6
GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway	6.140789e-6
GO:0090304	nucleic acid metabolic process	7.312657e-6
GO:0070368	positive regulation of hepatocyte differentiation	7.459333e-6
GO:0060620	regulation of cholesterol import	7.991368e-6
GO:0006730	one-carbon metabolic process	8.371087e-6
GO:0048143	astrocyte activation	8.622606e-6
GO:0050706	regulation of interleukin-1 beta secretion	1.152099e-5
GO:0031662	positive regulation of cyclin-dependent protein kinase activity involved in G2/M	1.411849e-5
GO:0035621	ER to Golgi ceramide transport	1.557971e-5
GO:0010758	regulation of macrophage chemotaxis	1.575654e-5
GO:0034380	high-density lipoprotein particle assembly	1.689561e-5
GO:0044330	canonical Wnt receptor signaling pathway involved in positive regulation of wound healing	1.841281e-5
GO:0044329	canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion	1.841281e-5
GO:0044328	canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration	1.841281e-5
GO:0043414	macromolecule methylation	1.923484e-5
GO:0071248	cellular response to metal ion	2.073977e-5
GO:0050713	negative regulation of interleukin-1 beta secretion	2.221864e-5
GO:0032695	negative regulation of interleukin-12 production	2.254602e-5
GO:0001841	neural tube formation	2.651217e-5
GO:0050704	regulation of interleukin-1 secretion	2.755528e-5
GO:0032375	negative regulation of cholesterol transport	3.127383e-5
GO:0065005	protein-lipid complex assembly	3.625118e-5
GO:0001510	RNA methylation	3.668152e-5
GO:0031915	positive regulation of synaptic plasticity	4.149868e-5
GO:0007091	mitotic metaphase/anaphase transition	4.269031e-5
GO:0032259	methylation	4.789401e-5
GO:0090209	negative regulation of triglyceride metabolic process	4.897824e-5
GO:0051313	attachment of spindle microtubules to chromosome	5.002421e-5
GO:0014002	astrocyte development	5.400992e-5
GO:0001838	embryonic epithelial tube formation	5.594505e-5
GO:0033211	adiponectin-mediated signaling pathway	5.658268e-5
GO:0033363	secretory granule organization	5.859375e-5
GO:0070535	histone H2A K63-linked ubiquitination	5.916704e-5
GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation	5.916704e-5
GO:0050708	regulation of protein secretion	6.375533e-5
GO:0034641	cellular nitrogen compound metabolic process	6.454591e-5
GO:0090072	positive regulation of sodium ion transport via voltage-gated sodium channel activity	6.668581e-5
GO:0051315	attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation	7.587825e-5
GO:0071247	cellular response to chromate	7.587825e-5
GO:0032274	gonadotropin secretion	7.849259e-5
GO:0072175	epithelial tube formation	8.033128e-5
GO:0044029	hypomethylation of CpG island	8.496008e-5
GO:0051639	actin filament network formation	9.130908e-5
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling	1.001504e-4
GO:0031247	actin rod assembly	1.010202e-4
GO:0000070	mitotic sister chromatid segregation	1.068137e-4
GO:0050711	negative regulation of interleukin-1 secretion	1.093794e-4
GO:0045717	negative regulation of fatty acid biosynthetic process	1.154746e-4
GO:0009988	cell-cell recognition	1.169324e-4
GO:0032225	regulation of synaptic transmission, dopaminergic	1.212705e-4
GO:0006566	threonine metabolic process	1.228236e-4
GO:0002098	tRNA wobble uridine modification	1.228236e-4
GO:0035239	tube morphogenesis	1.294021e-4
GO:0032074	negative regulation of nuclease activity	1.371953e-4
GO:0030070	insulin processing	1.437579e-4
GO:0019371	cyclooxygenase pathway	1.437579e-4
GO:0070194	synaptonemal complex disassembly	1.442972e-4
GO:0042158	lipoprotein biosynthetic process	1.517143e-4
GO:0006355	regulation of transcription, DNA-dependent	1.523421e-4
GO:0000819	sister chromatid segregation	1.524079e-4
GO:0008608	attachment of spindle microtubules to kinetochore	1.566516e-4
GO:0010759	positive regulation of macrophage chemotaxis	1.678822e-4
GO:0035481	positive regulation of Notch signaling pathway involved in heart induction	1.690910e-4
GO:0003259	cardioblast anterior-lateral migration	1.690910e-4
GO:0060975	cardioblast migration to the midline involved in heart field formation	1.690910e-4
GO:0003236	sinus venosus morphogenesis	1.690910e-4
GO:0003210	cardiac atrium formation	1.690910e-4
GO:0060920	pacemaker cell differentiation	1.833713e-4
GO:0048385	regulation of retinoic acid receptor signaling pathway	1.988436e-4
GO:0060921	sinoatrial node cell differentiation	2.003508e-4
GO:0051235	maintenance of location	2.067475e-4
GO:0046853	inositol or phosphatidylinositol phosphorylation	2.084648e-4
GO:0010467	gene expression	2.192496e-4
GO:0015696	ammonium transport	2.193332e-4
GO:0050710	negative regulation of cytokine secretion	2.324429e-4
GO:0003334	keratinocyte development	2.365428e-4
GO:0033364	mast cell secretory granule organization	2.393426e-4
GO:0032774	RNA biosynthetic process	2.458288e-4
GO:0018230	peptidyl-L-cysteine S-palmitoylation	2.515617e-4
GO:0006807	nitrogen compound metabolic process	2.520776e-4
GO:0010468	regulation of gene expression	2.545605e-4
GO:0035148	tube formation	2.629824e-4
GO:0002009	morphogenesis of an epithelium	2.653015e-4
GO:0032008	positive regulation of TOR signaling cascade	2.679128e-4
GO:0006351	transcription, DNA-dependent	2.701319e-4
GO:0006438	valyl-tRNA aminoacylation	2.728376e-4
GO:0030046	parallel actin filament bundle assembly	2.763397e-4
GO:0010172	embryonic body morphogenesis	2.805746e-4
GO:0010595	positive regulation of endothelial cell migration	3.433709e-4
GO:0051561	elevation of mitochondrial calcium ion concentration	3.634981e-4
GO:0051481	reduction of cytosolic calcium ion concentration	3.634981e-4
GO:0090212	negative regulation of establishment of blood-brain barrier	3.758911e-4
GO:0019047	provirus integration	3.758911e-4
GO:0060563	neuroepithelial cell differentiation	3.963276e-4
GO:0018192	enzyme active site formation via L-cysteine persulfide	4.101174e-4
GO:0032369	negative regulation of lipid transport	4.196633e-4
GO:0060562	epithelial tube morphogenesis	4.199367e-4
GO:0034337	RNA folding	4.221526e-4
GO:0032486	Rap protein signal transduction	4.404059e-4
GO:0051252	regulation of RNA metabolic process	4.430380e-4
GO:0071281	cellular response to iron ion	4.464701e-4
GO:0000422	mitochondrion degradation	4.464701e-4
GO:0071675	regulation of mononuclear cell migration	4.542673e-4
GO:0090129	positive regulation of synapse maturation	4.752348e-4
GO:0003283	atrial septum development	4.933302e-4
GO:0034453	microtubule anchoring	5.025603e-4
GO:0070508	cholesterol import	5.062450e-4
GO:0090128	regulation of synapse maturation	5.244289e-4
GO:0048259	regulation of receptor-mediated endocytosis	5.296907e-4
GO:0043968	histone H2A acetylation	5.326809e-4
GO:0007080	mitotic metaphase plate congression	5.344430e-4
GO:0071241	cellular response to inorganic substance	5.424113e-4
GO:0010575	positive regulation vascular endothelial growth factor production	5.448752e-4
GO:0017004	cytochrome complex assembly	5.588369e-4
GO:0042157	lipoprotein metabolic process	5.840174e-4
GO:0003161	cardiac conduction system development	5.845546e-4
GO:0007521	muscle cell fate determination	5.959467e-4
GO:0051276	chromosome organization	6.089279e-4
GO:0031326	regulation of cellular biosynthetic process	6.108286e-4
GO:0003163	sinoatrial node development	6.329801e-4
GO:0035752	lysosomal lumen pH elevation	6.338370e-4
GO:0001575	globoside metabolic process	6.338370e-4
GO:0000046	autophagic vacuole fusion	6.338370e-4
GO:0002739	regulation of cytokine secretion involved in immune response	6.421509e-4
GO:0003166	bundle of His development	6.696087e-4
GO:0006642	triglyceride mobilization	7.057365e-4
GO:0048790	maintenance of presynaptic active zone structure	7.163123e-4
GO:0045647	negative regulation of erythrocyte differentiation	7.173113e-4
GO:0045746	negative regulation of Notch signaling pathway	7.466441e-4
GO:0050995	negative regulation of lipid catabolic process	7.792999e-4
GO:0033700	phospholipid efflux	7.796724e-4
GO:0009443	pyridoxal 5'-phosphate salvage	7.999228e-4
GO:0032849	positive regulation of cellular pH reduction	8.135676e-4
GO:0018243	protein O-linked glycosylation via threonine	8.212415e-4
GO:0018242	protein O-linked glycosylation via serine	8.212415e-4
GO:0009451	RNA modification	8.626716e-4
GO:0002318	myeloid progenitor cell differentiation	9.169451e-4
GO:0016070	RNA metabolic process	9.196281e-4
GO:0003357	noradrenergic neuron differentiation	9.239299e-4
GO:0071544	diphosphoinositol polyphosphate catabolic process	9.378102e-4
GO:0015670	carbon dioxide transport	9.693819e-4
GO:0008033	tRNA processing	9.936726e-4
GO:0060255	regulation of macromolecule metabolic process	1.032012e-3
GO:0045922	negative regulation of fatty acid metabolic process	1.045492e-3
GO:2000112	regulation of cellular macromolecule biosynthetic process	1.076392e-3
GO:0019240	citrulline biosynthetic process	1.092235e-3
GO:0044260	cellular macromolecule metabolic process	1.102165e-3
GO:0030801	positive regulation of cyclic nucleotide metabolic process	1.117734e-3
GO:0032069	regulation of nuclease activity	1.119816e-3
GO:0003230	cardiac atrium development	1.132835e-3
GO:0010900	negative regulation of phosphatidylcholine catabolic process	1.148524e-3
GO:0001843	neural tube closure	1.205732e-3
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	1.218093e-3
GO:0015724	formate transport	1.228660e-3
GO:0014057	positive regulation of acetylcholine secretion	1.228660e-3
GO:0034375	high-density lipoprotein particle remodeling	1.256364e-3
GO:0090270	regulation of fibroblast growth factor production	1.268746e-3
GO:0034227	tRNA thio-modification	1.268746e-3
GO:0032606	type I interferon production	1.280583e-3
GO:0006303	double-strand break repair via nonhomologous end joining	1.280583e-3
GO:0030433	ER-associated protein catabolic process	1.316091e-3
GO:0051602	response to electrical stimulus	1.352070e-3
GO:0009889	regulation of biosynthetic process	1.423265e-3
GO:0014020	primary neural tube formation	1.426538e-3
GO:0003050	regulation of systemic arterial blood pressure by atrial natriuretic peptide	1.426808e-3
GO:0061370	testosterone biosynthetic process	1.426808e-3
GO:0040015	negative regulation of multicellular organism growth	1.426829e-3
GO:0019441	tryptophan catabolic process to kynurenine	1.459819e-3
GO:0006399	tRNA metabolic process	1.483388e-3
GO:0070541	response to platinum ion	1.490575e-3
GO:0001816	cytokine production	1.513955e-3
GO:0045185	maintenance of protein location	1.515985e-3
GO:0021915	neural tube development	1.558771e-3
GO:0034379	very-low-density lipoprotein particle assembly	1.586850e-3
GO:0000079	regulation of cyclin-dependent protein kinase activity	1.601289e-3
GO:0006334	nucleosome assembly	1.620557e-3
GO:0007264	small GTPase mediated signal transduction	1.664302e-3
GO:0033344	cholesterol efflux	1.683717e-3
GO:0050886	endocrine process	1.695786e-3
GO:0050709	negative regulation of protein secretion	1.721073e-3
GO:0071622	regulation of granulocyte chemotaxis	1.763149e-3
GO:0006325	chromatin organization	1.770270e-3
GO:0051590	positive regulation of neurotransmitter transport	1.786983e-3
GO:0002675	positive regulation of acute inflammatory response	1.795798e-3
GO:0071827	plasma lipoprotein particle organization	1.833504e-3
GO:0002763	positive regulation of myeloid leukocyte differentiation	1.846611e-3
GO:0050774	negative regulation of dendrite morphogenesis	1.851415e-3
GO:0051588	regulation of neurotransmitter transport	1.882123e-3
GO:2000761	positive regulation of N-terminal peptidyl-lysine acetylation	1.892845e-3
GO:0035910	ascending aorta morphogenesis	1.892845e-3
GO:0032691	negative regulation of interleukin-1 beta production	1.903078e-3
GO:0046670	positive regulation of retinal cell programmed cell death	1.911056e-3
GO:0090138	regulation of actin cytoskeleton organization by cell-cell adhesion	1.911056e-3
GO:0046079	dUMP catabolic process	1.911056e-3
GO:0002525	acute inflammatory response to non-antigenic stimulus	1.911056e-3
GO:0003409	optic cup structural organization	1.925926e-3
GO:0021623	oculomotor nerve formation	1.925926e-3
GO:0003404	optic vesicle morphogenesis	1.925926e-3
GO:0042664	negative regulation of endodermal cell fate specification	1.951568e-3
GO:0009088	threonine biosynthetic process	1.951568e-3
GO:0040040	thermosensory behavior	1.951568e-3
GO:0051659	maintenance of mitochondrion location	2.003202e-3
GO:0009225	nucleotide-sugar metabolic process	2.014756e-3
GO:2000279	negative regulation of DNA biosynthetic process	2.020430e-3
GO:0030728	ovulation	2.035178e-3
GO:0042147	retrograde transport, endosome to Golgi	2.050308e-3
GO:0002740	negative regulation of cytokine secretion involved in immune response	2.053906e-3
GO:0060606	tube closure	2.106215e-3
GO:0035815	positive regulation of renal sodium excretion	2.150056e-3
GO:0034645	cellular macromolecule biosynthetic process	2.169366e-3
GO:0060986	endocrine hormone secretion	2.315183e-3
GO:0006561	proline biosynthetic process	2.323627e-3
GO:2000286	receptor internalization involved in canonical Wnt receptor signaling pathway	2.323627e-3
GO:0071318	cellular response to ATP	2.340173e-3
GO:0016241	regulation of macroautophagy	2.340173e-3
GO:0014061	regulation of norepinephrine secretion	2.393642e-3
GO:0051171	regulation of nitrogen compound metabolic process	2.402915e-3
GO:0048387	negative regulation of retinoic acid receptor signaling pathway	2.404213e-3
GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation	2.495604e-3
GO:0051454	intracellular pH elevation	2.495604e-3
GO:0008582	regulation of synaptic growth at neuromuscular junction	2.495604e-3
GO:0035269	protein O-linked mannosylation	2.495604e-3
GO:0007126	meiosis	2.536092e-3
GO:0031175	neuron projection development	2.543664e-3
GO:0030819	positive regulation of cAMP biosynthetic process	2.593188e-3
GO:0001542	ovulation from ovarian follicle	2.640640e-3
GO:0090049	regulation of cell migration involved in sprouting angiogenesis	2.654413e-3
GO:0001973	adenosine receptor signaling pathway	2.654413e-3
GO:0045672	positive regulation of osteoclast differentiation	2.672627e-3
GO:0003214	cardiac left ventricle morphogenesis	2.762964e-3
GO:0090381	regulation of heart induction	2.819764e-3
GO:0090361	regulation of platelet-derived growth factor production	2.819764e-3
GO:0033148	positive regulation of estrogen receptor signaling pathway	2.861769e-3
GO:0070634	transepithelial ammonium transport	2.861769e-3
GO:0021965	spinal cord ventral commissure morphogenesis	2.905294e-3
GO:0040029	regulation of gene expression, epigenetic	2.910258e-3
GO:0006289	nucleotide-excision repair	2.919042e-3
GO:0001834	trophectodermal cell proliferation	2.923000e-3
GO:0000281	cytokinesis after mitosis	2.951051e-3
GO:0007339	binding of sperm to zona pellucida	2.986366e-3
GO:0016570	histone modification	2.996492e-3
GO:0032367	intracellular cholesterol transport	3.008641e-3
GO:0016331	morphogenesis of embryonic epithelium	3.016513e-3
GO:0019219	regulation of nucleobase-containing compound metabolic process	3.161480e-3
GO:0007049	cell cycle	3.267515e-3
GO:0051657	maintenance of organelle location	3.331216e-3
GO:0045806	negative regulation of endocytosis	3.387752e-3
GO:0006414	translational elongation	3.387752e-3
GO:0046939	nucleotide phosphorylation	3.396643e-3
GO:0032692	negative regulation of interleukin-1 production	3.397443e-3
GO:0048643	positive regulation of skeletal muscle tissue development	3.410836e-3
GO:0030804	positive regulation of cyclic nucleotide biosynthetic process	3.422732e-3
GO:0060743	epithelial cell maturation involved in prostate gland development	3.439618e-3
GO:0043691	reverse cholesterol transport	3.507515e-3
GO:0010836	negative regulation of protein ADP-ribosylation	3.525626e-3
GO:0000389	nuclear mRNA 3'-splice site recognition	3.525626e-3
GO:0000236	mitotic prometaphase	3.525626e-3
GO:0050715	positive regulation of cytokine secretion	3.584529e-3
GO:0016568	chromatin modification	3.612057e-3
GO:0010430	fatty acid omega-oxidation	3.653022e-3
GO:0009159	deoxyribonucleoside monophosphate catabolic process	3.653022e-3
GO:0009438	methylglyoxal metabolic process	3.653022e-3
GO:0003289	atrial septum primum morphogenesis	3.732240e-3
GO:0010458	exit from mitosis	3.747559e-3
GO:0010594	regulation of endothelial cell migration	3.750373e-3
GO:0043170	macromolecule metabolic process	3.925582e-3
GO:0032227	negative regulation of synaptic transmission, dopaminergic	3.988559e-3
GO:0090303	positive regulation of wound healing	4.000957e-3
GO:0070172	positive regulation of tooth mineralization	4.000957e-3
GO:0006479	protein methylation	4.075302e-3
GO:0034446	substrate adhesion-dependent cell spreading	4.091380e-3
GO:0050714	positive regulation of protein secretion	4.127195e-3
GO:0022904	respiratory electron transport chain	4.157488e-3
GO:0043316	cytotoxic T cell degranulation	4.179441e-3
GO:0048633	positive regulation of skeletal muscle tissue growth	4.179441e-3
GO:0003241	growth involved in heart morphogenesis	4.179441e-3
GO:0051321	meiotic cell cycle	4.203346e-3
GO:0042178	xenobiotic catabolic process	4.301712e-3
GO:0009059	macromolecule biosynthetic process	4.314063e-3
GO:0051451	myoblast migration	4.385758e-3
GO:0014014	negative regulation of gliogenesis	4.415061e-3
GO:0014009	glial cell proliferation	4.450779e-3
GO:0010817	regulation of hormone levels	4.582533e-3
GO:0045351	type I interferon biosynthetic process	4.602621e-3
GO:0032651	regulation of interleukin-1 beta production	4.683799e-3
GO:0051954	positive regulation of amine transport	4.702394e-3
GO:0006259	DNA metabolic process	4.822314e-3
GO:0060045	positive regulation of cardiac muscle cell proliferation	4.835424e-3
GO:0016569	covalent chromatin modification	4.842271e-3
GO:0003179	heart valve morphogenesis	4.859085e-3
GO:0051055	negative regulation of lipid biosynthetic process	4.859085e-3
GO:0034728	nucleosome organization	5.114589e-3
GO:0018198	peptidyl-cysteine modification	5.146111e-3
GO:0006568	tryptophan metabolic process	5.146111e-3
GO:0072126	positive regulation of glomerular mesangial cell proliferation	5.305305e-3
GO:0050975	sensory perception of touch	5.305305e-3
GO:0071506	cellular response to mycophenolic acid	5.305305e-3
GO:0051129	negative regulation of cellular component organization	5.353022e-3
GO:0065004	protein-DNA complex assembly	5.410405e-3
GO:0018210	peptidyl-threonine modification	5.434188e-3
GO:0010556	regulation of macromolecule biosynthetic process	5.558104e-3
GO:0051651	maintenance of location in cell	5.571548e-3
GO:0009132	nucleoside diphosphate metabolic process	5.676187e-3
GO:0034201	response to oleic acid	5.688322e-3
GO:0070189	kynurenine metabolic process	5.688322e-3
GO:0035036	sperm-egg recognition	5.753500e-3
GO:0042360	vitamin E metabolic process	5.755265e-3
GO:0010999	regulation of eIF2 alpha phosphorylation by heme	5.755265e-3
GO:0009589	detection of UV	5.755265e-3
GO:0034976	response to endoplasmic reticulum stress	6.047738e-3
GO:0006970	response to osmotic stress	6.080514e-3
GO:0045004	DNA replication proofreading	6.110870e-3
GO:0010983	positive regulation of high-density lipoprotein particle clearance	6.110870e-3
GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific	6.110870e-3
GO:0045989	positive regulation of striated muscle contraction	6.149422e-3
GO:0071294	cellular response to zinc ion	6.151902e-3
GO:0035810	positive regulation of urine volume	6.151902e-3
GO:0048641	regulation of skeletal muscle tissue development	6.229721e-3
GO:0046709	IDP catabolic process	6.358320e-3
GO:0046032	ADP catabolic process	6.358320e-3
GO:0014745	negative regulation of muscle adaptation	6.358320e-3
GO:0018076	N-terminal peptidyl-lysine acetylation	6.358320e-3
GO:0003300	cardiac muscle hypertrophy	6.359124e-3
GO:2000297	negative regulation of synapse maturation	6.729645e-3
GO:0090174	organelle membrane fusion	6.729645e-3
GO:0001913	T cell mediated cytotoxicity	6.729645e-3
GO:0051586	positive regulation of dopamine uptake	6.729645e-3
GO:0003151	outflow tract morphogenesis	6.810962e-3
GO:0010574	regulation of vascular endothelial growth factor production	6.846210e-3
GO:0061303	cornea development in camera-type eye	6.850659e-3
GO:0003209	cardiac atrium morphogenesis	6.890636e-3
GO:0000726	non-recombinational repair	6.906975e-3
GO:0048743	positive regulation of skeletal muscle fiber development	7.001945e-3
GO:0060413	atrial septum morphogenesis	7.042270e-3
GO:0030854	positive regulation of granulocyte differentiation	7.229037e-3
GO:2000648	positive regulation of stem cell proliferation	7.397530e-3
GO:0032594	protein transport within lipid bilayer	7.441414e-3
GO:0070198	protein localization to chromosome, telomeric region	7.441414e-3
GO:0003170	heart valve development	7.447172e-3
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	7.470979e-3
GO:0002070	epithelial cell maturation	7.501436e-3
GO:0002673	regulation of acute inflammatory response	7.609525e-3
GO:0038027	apolipoprotein A-I-mediated signaling pathway	7.682247e-3
GO:0051155	positive regulation of striated muscle cell differentiation	7.728133e-3
GO:0003308	negative regulation of Wnt receptor signaling pathway involved in heart development	7.808199e-3
GO:0051004	regulation of lipoprotein lipase activity	7.818431e-3
GO:0033522	histone H2A ubiquitination	7.949971e-3
GO:0003183	mitral valve morphogenesis	8.029071e-3
GO:0032652	regulation of interleukin-1 production	8.063333e-3
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	8.169597e-3
GO:0072610	interleukin-12 secretion	8.289303e-3
GO:0097022	lymphocyte migration into lymph node	8.289303e-3
GO:0032206	positive regulation of telomere maintenance	8.289303e-3
GO:2000278	regulation of DNA biosynthetic process	8.298853e-3
GO:0015669	gas transport	8.362156e-3
GO:0071824	protein-DNA complex subunit organization	8.529266e-3
GO:0034470	ncRNA processing	8.613419e-3
GO:0033239	negative regulation of cellular amine metabolic process	8.624472e-3
GO:0003062	regulation of heart rate by chemical signal	8.624472e-3
GO:0007028	cytoplasm organization	8.624472e-3
GO:0007292	female gamete generation	8.707348e-3
GO:0042304	regulation of fatty acid biosynthetic process	8.797016e-3
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	8.821990e-3
GO:0002649	regulation of tolerance induction to self antigen	8.821990e-3
GO:0016242	negative regulation of macroautophagy	8.906232e-3
GO:0051310	metaphase plate congression	8.984405e-3
GO:0048167	regulation of synaptic plasticity	9.228805e-3
GO:0034381	plasma lipoprotein particle clearance	9.250728e-3
GO:0010873	positive regulation of cholesterol esterification	9.270766e-3
GO:0045992	negative regulation of embryonic development	9.347605e-3
GO:0022409	positive regulation of cell-cell adhesion	9.393579e-3
GO:0010955	negative regulation of protein processing	9.424508e-3
GO:0034660	ncRNA metabolic process	9.544480e-3
GO:0045933	positive regulation of muscle contraction	9.559569e-3
GO:0031323	regulation of cellular metabolic process	9.667949e-3
GO:0045109	intermediate filament organization	9.699029e-3
GO:0043065	positive regulation of apoptosis	9.709590e-3
GO:0048666	neuron development	9.782943e-3
GO:0051891	positive regulation of cardioblast differentiation	9.794696e-3
GO:0046785	microtubule polymerization	9.811930e-3
GO:0044030	regulation of DNA methylation	9.870492e-3
GO:0031622	positive regulation of fever generation	9.948298e-3
GO:0021954	central nervous system neuron development	9.987972e-3
GO:0046940	nucleoside monophosphate phosphorylation	9.989203e-3
GO:0097026	dendritic cell dendrite assembly	1.008242e-2
GO:0090310	negative regulation of methylation-dependent chromatin silencing	1.008242e-2
GO:0021629	olfactory nerve structural organization	1.008242e-2
GO:0061099	negative regulation of protein tyrosine kinase activity	1.011883e-2
GO:0034502	protein localization to chromosome	1.011883e-2
GO:0003208	cardiac ventricle morphogenesis	1.015502e-2
GO:0035417	negative regulation of mitotic prometaphase	1.015828e-2
GO:0070254	mucus secretion	1.015828e-2
GO:0042376	phylloquinone catabolic process	1.015828e-2
GO:0033260	DNA replication involved in S phase	1.015828e-2
GO:0010266	response to vitamin B1	1.015828e-2
GO:0035117	embryonic arm morphogenesis	1.017300e-2
GO:0010498	proteasomal protein catabolic process	1.034406e-2
GO:0009074	aromatic amino acid family catabolic process	1.040124e-2
GO:0035166	post-embryonic hemopoiesis	1.042148e-2
GO:0032006	regulation of TOR signaling cascade	1.042565e-2
GO:0060596	mammary placode formation	1.048046e-2
GO:0070170	regulation of tooth mineralization	1.064875e-2
GO:0002523	leukocyte migration involved in inflammatory response	1.113989e-2
GO:0072488	ammonium transmembrane transport	1.118411e-2
GO:0050873	brown fat cell differentiation	1.124957e-2
GO:0032456	endocytic recycling	1.145456e-2
GO:0034968	histone lysine methylation	1.161185e-2
GO:0031497	chromatin assembly	1.189759e-2
GO:0097006	regulation of plasma lipoprotein particle levels	1.192548e-2
GO:0048814	regulation of dendrite morphogenesis	1.201883e-2
GO:0033563	dorsal/ventral axon guidance	1.211075e-2
GO:0070366	regulation of hepatocyte differentiation	1.211075e-2
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	1.212420e-2
GO:0001935	endothelial cell proliferation	1.235258e-2
GO:0002328	pro-B cell differentiation	1.238441e-2
GO:0070584	mitochondrion morphogenesis	1.245409e-2
GO:0006541	glutamine metabolic process	1.252850e-2
GO:0060155	platelet dense granule organization	1.268998e-2
GO:0045916	negative regulation of complement activation	1.268998e-2
GO:0032226	positive regulation of synaptic transmission, dopaminergic	1.270174e-2
GO:0043068	positive regulation of programmed cell death	1.287405e-2
GO:0032847	regulation of cellular pH reduction	1.300985e-2
GO:0015809	arginine transport	1.300985e-2
GO:0006400	tRNA modification	1.301102e-2
GO:0035082	axoneme assembly	1.308203e-2
GO:0046826	negative regulation of protein export from nucleus	1.337097e-2
GO:0048742	regulation of skeletal muscle fiber development	1.338530e-2
GO:0080009	mRNA methylation	1.340708e-2
GO:2000612	regulation of thyroid-stimulating hormone secretion	1.340708e-2
GO:0070625	zymogen granule exocytosis	1.340708e-2
GO:0042264	peptidyl-aspartic acid hydroxylation	1.340708e-2
GO:0010986	positive regulation of lipoprotein particle clearance	1.340708e-2
GO:0016598	protein arginylation	1.340708e-2
GO:0010760	negative regulation of macrophage chemotaxis	1.340708e-2
GO:0090288	negative regulation of cellular response to growth factor stimulus	1.346564e-2
GO:0060932	His-Purkinje system cell differentiation	1.387841e-2
GO:0060926	pacemaker cell development	1.387841e-2
GO:0070509	calcium ion import	1.392650e-2
GO:0007549	dosage compensation	1.392650e-2
GO:0022900	electron transport chain	1.395091e-2
GO:0051583	dopamine uptake	1.398352e-2
GO:0070988	demethylation	1.399542e-2
GO:0060696	regulation of phospholipid catabolic process	1.432633e-2
GO:0001771	immunological synapse formation	1.432633e-2
GO:0060011	Sertoli cell proliferation	1.433619e-2
GO:0021999	neural plate anterior/posterior regionalization	1.433619e-2
GO:0070498	interleukin-1-mediated signaling pathway	1.441634e-2
GO:0072321	chaperone-mediated protein transport	1.442893e-2
GO:0045590	negative regulation of regulatory T cell differentiation	1.442893e-2
GO:0030719	P granule organization	1.442893e-2
GO:0043201	response to leucine	1.442893e-2
GO:0043415	positive regulation of skeletal muscle tissue regeneration	1.442893e-2
GO:0044270	cellular nitrogen compound catabolic process	1.446097e-2
GO:0071236	cellular response to antibiotic	1.449336e-2
GO:0003139	secondary heart field specification	1.463298e-2
GO:0010901	regulation of very-low-density lipoprotein particle remodeling	1.463298e-2
GO:0002072	optic cup morphogenesis involved in camera-type eye development	1.463298e-2
GO:0016265	death	1.466376e-2
GO:0040019	positive regulation of embryonic development	1.467741e-2
GO:0016577	histone demethylation	1.467741e-2
GO:0060900	embryonic camera-type eye formation	1.469348e-2
GO:0001893	maternal placenta development	1.502564e-2
GO:0042254	ribosome biogenesis	1.525526e-2
GO:0008219	cell death	1.527143e-2
GO:0046039	GTP metabolic process	1.537795e-2
GO:0009261	ribonucleotide catabolic process	1.547888e-2
GO:0060911	cardiac cell fate commitment	1.552261e-2