UBERON:0004715

Name:	annulus fibrosus disci intervertebralis
Namespace:	FANTOM
Definition:	"The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised." [BTO:0003629, Wikipedia:Annulus_fibrosus_disci_intervertebralis]
Xrefs:	Expandlinks: BTO:0003629 FMA:13551 [ Cervical_vertebra_english.png] [ 200px-Cervical_vertebra_english.png] MA:0000111 Wikipedia:Annulus_fibrosus_disci_intervertebralis
Synonyms:	"annulus fibrosus" BROAD [MA:0000111] "annulus fibrosus of intervertebral disc" RELATED [BTO:0003629] "anulus fibrosus (diskus intervertebralis)" EXACT [FMA:13551] "anulus fibrosus of intervertebral disk" EXACT [FMA:13551] "fibrous ring of intervertebral disc" RELATED [BTO:0003629]

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

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Parents

is_a:	UBERON:0004120(mesoderm-derived structure),UBERON:0006444(annulus fibrosus)
part_of:	UBERON:0001066(intervertebral disk)

Children

part of:	CL:0002602 (annulus pulposus cell)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

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Human (Homo sapiens)

• 11248-116E6 (Anulus Pulposus Cell, donor1)
• 11463-119B5 (Anulus Pulposus Cell, donor2)

Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0004715 (annulus fibrosus disci intervertebralis), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

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P-value	FFCP	Short description

P-value	FFCP	Short description
5.68e-99	FFCP PHASE2:Hg19::chr1:78769549..78769554,+	p5@PTGFR
5.68e-99	FFCP PHASE1:Hg19::chr1:78769549..78769554,+	p5@PTGFR
1.55e-98	FFCP PHASE1:Hg19::chr13:24914614..24914622,-	p@chr13:24914614..24914622, -
1.55e-98	FFCP PHASE2:Hg19::chr13:24914614..24914622,-	p@chr13:24914614..24914622, -
2.34e-79	FFCP PHASE2:Hg19::chr9:114135497..114135526,-	p@chr9:114135497..114135526, -
2.34e-79	FFCP PHASE1:Hg19::chr9:114135497..114135526,-	p@chr9:114135497..114135526, -
1.45e-66	FFCP PHASE2:Hg19::chr3:174737010..174737023,+	p@chr3:174737010..174737023, +
1.45e-66	FFCP PHASE1:Hg19::chr3:174737010..174737023,+	p@chr3:174737010..174737023, +
2.84e-66	FFCP PHASE2:Hg19::chr2:241897189..241897221,-	p@chr2:241897189..241897221, -
2.84e-66	FFCP PHASE1:Hg19::chr2:241897189..241897221,-	p@chr2:241897189..241897221, -
1.13e-57	FFCP PHASE2:Hg19::chr20:21687193..21687206,+	p4@PAX1
1.13e-57	FFCP PHASE2:Hg19::chr10:81923378..81923389,-	p@chr10:81923378..81923389, -
1.13e-57	FFCP PHASE1:Hg19::chr20:21687193..21687206,+	p4@PAX1
1.13e-57	FFCP PHASE2:Hg19::chr20:21687260..21687270,+	p3@PAX1
1.13e-57	FFCP PHASE1:Hg19::chr20:21687260..21687270,+	p3@PAX1
1.13e-57	FFCP PHASE1:Hg19::chr10:81923378..81923389,-	p@chr10:81923378..81923389, -
1.14e-50	FFCP PHASE2:Hg19::chr4:13546583..13546593,-	p3@NKX3-2
1.14e-50	FFCP PHASE1:Hg19::chr4:13546583..13546593,-	p3@NKX3-2
1.46e-50	FFCP PHASE2:Hg19::chr4:13546130..13546145,-	p4@NKX3-2
1.46e-50	FFCP PHASE1:Hg19::chr4:13546130..13546145,-	p4@NKX3-2
2.74e-50	FFCP PHASE2:Hg19::chr16:4421890..4421912,-	p@chr16:4421890..4421912, -
2.74e-50	FFCP PHASE1:Hg19::chr16:4421890..4421912,-	p@chr16:4421890..4421912, -
3.19e-45	FFCP PHASE2:Hg19::chr2:241897125..241897142,-	p@chr2:241897125..241897142, -
3.19e-45	FFCP PHASE1:Hg19::chr2:241897125..241897142,-	p@chr2:241897125..241897142, -
1.22e-44	FFCP PHASE2:Hg19::chr3:80727046..80727051,-	p@chr3:80727046..80727051, -
1.22e-44	FFCP PHASE1:Hg19::chr3:80727046..80727051,-	p@chr3:80727046..80727051, -
5.99e-41	FFCP PHASE2:Hg19::chr5:30104176..30104187,-	p@chr5:30104176..30104187, -
5.99e-41	FFCP PHASE1:Hg19::chr5:30104176..30104187,-	p@chr5:30104176..30104187, -
3.01e-40	FFCP PHASE2:Hg19::chr1:19778678..19778689,-	p@chr1:19778678..19778689, -
3.01e-40	FFCP PHASE1:Hg19::chr1:19778678..19778689,-	p@chr1:19778678..19778689, -
1.3e-37	FFCP PHASE1:Hg19::chr20:21695435..21695452,+	p@chr20:21695435..21695452, +
1.3e-37	FFCP PHASE2:Hg19::chr20:21695435..21695452,+	p@chr20:21695435..21695452, +
3.94e-37	FFCP PHASE2:Hg19::chr16:70795228..70795237,+	p@chr16:70795228..70795237, +
3.94e-37	FFCP PHASE1:Hg19::chr16:70795228..70795237,+	p@chr16:70795228..70795237, +
8.2e-37	FFCP PHASE2:Hg19::chr14:23574186..23574212,-	p1@uc010aki.1
8.2e-37	FFCP PHASE1:Hg19::chr14:23574186..23574212,-	p1@uc010aki.1
1.18e-36	FFCP PHASE2:Hg19::chr8:27455513..27455516,+	p7@CU679734
1.18e-36	FFCP PHASE1:Hg19::chr8:27455513..27455516,+	p7@CU679734
7.05e-34	FFCP PHASE2:Hg19::chr14:23574164..23574179,-	p3@uc010aki.1
7.05e-34	FFCP PHASE1:Hg19::chr14:23574164..23574179,-	p3@uc010aki.1
8.05e-30	FFCP PHASE2:Hg19::chr11:66724317..66724340,-	p@chr11:66724317..66724340, -
8.05e-30	FFCP PHASE1:Hg19::chr11:66724317..66724340,-	p@chr11:66724317..66724340, -
2.22e-29	FFCP PHASE2:Hg19::chr2:53161632..53161661,-	p@chr2:53161632..53161661, -
2.22e-29	FFCP PHASE1:Hg19::chr2:53161632..53161661,-	p@chr2:53161632..53161661, -
5.41e-28	FFCP PHASE1:Hg19::chr2:242004292..242004308,+	p15@SNED1
5.41e-28	FFCP PHASE2:Hg19::chr2:242004292..242004308,+	p15@SNED1
7.1e-28	FFCP PHASE2:Hg19::chr1:19811132..19811155,-	p20@CAPZB
7.1e-28	FFCP PHASE1:Hg19::chr1:19811132..19811155,-	p20@CAPZB
2.09e-27	FFCP PHASE2:Hg19::chr8:25337491..25337504,+	p@chr8:25337491..25337504, +
2.09e-27	FFCP PHASE1:Hg19::chr8:25337491..25337504,+	p@chr8:25337491..25337504, +
3.59e-26	FFCP PHASE1:Hg19::chr2:241897363..241897398,+	p@chr2:241897363..241897398, +
3.59e-26	FFCP PHASE2:Hg19::chr2:241897363..241897398,+	p@chr2:241897363..241897398, +
3.89e-25	FFCP PHASE1:Hg19::chr6:158490457..158490470,+	p10@SYNJ2
3.89e-25	FFCP PHASE2:Hg19::chr6:158490457..158490470,+	p10@SYNJ2
5.58e-25	FFCP PHASE1:Hg19::chr7:18832801..18832816,+	p21@HDAC9
5.58e-25	FFCP PHASE2:Hg19::chr7:18832801..18832816,+	p21@HDAC9
1.02e-24	FFCP PHASE1:Hg19::chr9:16138889..16138902,-	p@chr9:16138889..16138902, -
1.02e-24	FFCP PHASE2:Hg19::chr9:16138889..16138902,-	p@chr9:16138889..16138902, -
1.45e-24	FFCP PHASE2:Hg19::chr2:241938405..241938416,+	p@chr2:241938405..241938416, +
1.45e-24	FFCP PHASE1:Hg19::chr2:241938405..241938416,+	p@chr2:241938405..241938416, +
2.34e-24	FFCP PHASE2:Hg19::chr8:78311303..78311320,+	p2@ENST00000518706
2.34e-24	FFCP PHASE1:Hg19::chr8:78311303..78311320,+	p2@ENST00000518706
6.77e-24	FFCP PHASE2:Hg19::chr21:39705383..39705394,-	p1@ENST00000436845
6.77e-24	FFCP PHASE1:Hg19::chr21:39705383..39705394,-	p1@ENST00000436845
8.02e-24	FFCP PHASE2:Hg19::chr17:38655950..38655954,+	p@chr17:38655950..38655954, +
8.02e-24	FFCP PHASE1:Hg19::chr17:38655950..38655954,+	p@chr17:38655950..38655954, +
1.13e-23	FFCP PHASE1:Hg19::chr14:61190754..61190776,-	p6@SIX4
1.13e-23	FFCP PHASE2:Hg19::chr14:61190754..61190776,-	p6@SIX4
1.78e-23	FFCP PHASE2:Hg19::chr1:78695298..78695311,+	p1@ENST00000413519
1.78e-23	FFCP PHASE1:Hg19::chr1:78695298..78695311,+	p1@ENST00000413519
1.14e-21	FFCP PHASE2:Hg19::chr11:60610073..60610090,+	p6@CCDC86
1.14e-21	FFCP PHASE1:Hg19::chr11:60610073..60610090,+	p6@CCDC86
1.53e-21	FFCP PHASE2:Hg19::chr7:18832913..18832946,+	p19@HDAC9
1.53e-21	FFCP PHASE1:Hg19::chr7:18832913..18832946,+	p19@HDAC9
3.47e-21	FFCP PHASE2:Hg19::chr20:30181389..30181408,+	p@chr20:30181389..30181408, +
3.47e-21	FFCP PHASE1:Hg19::chr20:30181389..30181408,+	p@chr20:30181389..30181408, +
3.81e-21	FFCP PHASE2:Hg19::chr3:158384350..158384362,-	p@chr3:158384350..158384362, -
3.81e-21	FFCP PHASE1:Hg19::chr3:158384350..158384362,-	p@chr3:158384350..158384362, -
4.66e-21	FFCP PHASE2:Hg19::chr18:12012068..12012098,+	p@chr18:12012068..12012098, +
4.66e-21	FFCP PHASE1:Hg19::chr18:12012068..12012098,+	p@chr18:12012068..12012098, +
5.2e-21	FFCP PHASE2:Hg19::chr7:158224707..158224729,-	p@chr7:158224707..158224729, -
5.2e-21	FFCP PHASE1:Hg19::chr7:158224707..158224729,-	p@chr7:158224707..158224729, -
6.96e-21	FFCP PHASE2:Hg19::chr2:158345440..158345449,-	p9@CYTIP
6.96e-21	FFCP PHASE1:Hg19::chr2:158345440..158345449,-	p9@CYTIP
6.96e-21	FFCP PHASE2:Hg19::chr11:108743668..108743675,+	p@chr11:108743668..108743675, +
6.96e-21	FFCP PHASE1:Hg19::chr11:108743668..108743675,+	p@chr11:108743668..108743675, +
8.49e-21	FFCP PHASE2:Hg19::chr6:158490395..158490407,+	p9@SYNJ2
8.49e-21	FFCP PHASE1:Hg19::chr6:158490395..158490407,+	p9@SYNJ2
2.74e-20	FFCP PHASE2:Hg19::chr1:65888177..65888194,+	p@chr1:65888177..65888194, +
2.74e-20	FFCP PHASE1:Hg19::chr1:65888177..65888194,+	p@chr1:65888177..65888194, +
1.64e-19	FFCP PHASE1:Hg19::chr19:14223369..14223385,-	p5@PRKACA
1.64e-19	FFCP PHASE2:Hg19::chr19:14223369..14223385,-	p5@PRKACA
2.38e-19	FFCP PHASE2:Hg19::chr9:113798560..113798572,-	p34@LPAR1
2.38e-19	FFCP PHASE1:Hg19::chr9:113798560..113798572,-	p34@LPAR1
4.53e-19	FFCP PHASE2:Hg19::chr17:73688878..73688882,+	p@chr17:73688878..73688882, +
4.53e-19	FFCP PHASE1:Hg19::chr17:73688878..73688882,+	p@chr17:73688878..73688882, +
6.53e-19	FFCP PHASE2:Hg19::chr3:58572689..58572703,-	p6@FAM107A
6.53e-19	FFCP PHASE1:Hg19::chr3:58572689..58572703,-	p6@FAM107A
7.03e-19	FFCP PHASE2:Hg19::chr1:78695274..78695292,+	p1@MGC27382
7.03e-19	FFCP PHASE1:Hg19::chr1:78695274..78695292,+	p1@MGC27382

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