Coexpression cluster:C208

Full id: C208_skin_amniotic_papillotubular_salivary_umbilical_Alveolar_serous

Phase1 CAGE Peaks

Hg19::chr10:94301107..94301111,-	p18@IDE
Hg19::chr11:105010477..105010516,-	p1@CARD18
Hg19::chr11:65779425..65779509,+	p1@CST6
Hg19::chr11:65779676..65779683,+	p12@CST6
Hg19::chr12:52685312..52685319,-	p11@KRT81
Hg19::chr12:52695617..52695623,+	p4@KRT86
Hg19::chr12:52715179..52715182,-	p1@KRT83
Hg19::chr12:52761262..52761267,-	p1@KRT85
Hg19::chr12:52946923..52946931,-	p1@KRT71
Hg19::chr12:52967622..52967628,-	p1@KRT74
Hg19::chr12:52995291..52995294,-	p5@KRT72
Hg19::chr12:53097305..53097310,-	p1@KRT77
Hg19::chr12:53228091..53228096,-	p1@KRT79
Hg19::chr16:56598984..56598990,+	p1@MT4
Hg19::chr17:20687950..20687982,+	p1@SCDP1
Hg19::chr17:38911580..38911584,-	p1@KRT25
Hg19::chr17:38938796..38938803,-	p1@KRT27
Hg19::chr17:38956205..38956214,-	p1@KRT28
Hg19::chr17:39165376..39165381,-	p1@KRTAP3-1
Hg19::chr17:39191123..39191127,-	p1@KRTAP1-3
Hg19::chr17:39254391..39254395,-	p1@KRTAP4-8
Hg19::chr17:39274621..39274626,-	p1@KRTAP4-11
Hg19::chr17:39280430..39280436,-	p1@KRTAP4-12
Hg19::chr17:39296794..39296798,-	p1@KRTAP4-6
Hg19::chr17:39306068..39306077,-	p1@KRTAP4-5
Hg19::chr17:39316998..39317001,-	p1@KRTAP4-4
Hg19::chr17:39324471..39324474,-	p1@KRTAP4-3
Hg19::chr17:39334471..39334474,-	p1@KRTAP4-2
Hg19::chr17:39341160..39341165,-	p1@KRTAP4-1
Hg19::chr17:39388700..39388702,+	p1@KRTAP9-3 p1@KRTAP9-9
Hg19::chr17:39394250..39394253,+	p1@KRTAP9-8
Hg19::chr17:39465536..39465562,-	p1@KRTAP16-1
Hg19::chr17:39471958..39471963,-	p1@KRTAP17-1
Hg19::chr17:39507076..39507080,-	p1@KRT33A
Hg19::chr17:39553852..39553863,-	p1@KRT31
Hg19::chr17:39637401..39637404,-	p1@KRT35
Hg19::chr17:48261972..48261979,-	p@chr17:48261972..48261979 -
Hg19::chr17:48262782..48262783,-	p55@COL1A1
Hg19::chr18:61209598..61209607,+	p@chr18:61209598..61209607 +
Hg19::chr18:61209634..61209647,+	p@chr18:61209634..61209647 +
Hg19::chr18:61209658..61209665,+	p@chr18:61209658..61209665 +
Hg19::chr19:24140738..24140740,-	p1@uc002nrp.1
Hg19::chr19:46753446..46753471,-	p@chr19:46753446..46753471 -
Hg19::chr1:152061537..152061542,-	p1@TCHHL1
Hg19::chr1:152087919..152087921,-	p1@TCHH
Hg19::chr1:152286909..152286919,-	p2@FLG
Hg19::chr1:152287109..152287120,-	p3@FLG
Hg19::chr1:152332480..152332484,-	p1@FLG2
Hg19::chr1:152483278..152483280,+	p1@LCE5A
Hg19::chr1:152627927..152627931,+	p1@LINC00302
Hg19::chr1:152635854..152635860,+	p1@LCE2D
Hg19::chr1:152691067..152691070,+	p1@C1orf68
Hg19::chr1:152815327..152815336,+	p1@LCE6A
Hg19::chr1:152943122..152943128,+	p1@SPRR4
Hg19::chr1:153232160..153232165,+	p1@LOR
Hg19::chr1:153522562..153522578,-	p11@S100A4
Hg19::chr1:1567038..1567075,+	p4@MMP23B
Hg19::chr1:179242347..179242350,+	p@chr1:179242347..179242350 +
Hg19::chr21:31655265..31655269,-	p1@KRTAP24-1
Hg19::chr21:31852683..31852688,-	p1@KRTAP19-1
Hg19::chr21:31874456..31874461,-	p1@KRTAP19-5
Hg19::chr21:32185588..32185592,-	p1@KRTAP8-1
Hg19::chr21:32202074..32202079,-	p1@KRTAP7-1
Hg19::chr21:32253891..32253899,-	p1@KRTAP11-1
Hg19::chr21:45978676..45978679,-	p1@KRTAP10-3
Hg19::chr21:46047009..46047014,+	p1@KRTAP10-9
Hg19::chr21:46132193..46132201,-	p@chr21:46132193..46132201 -
Hg19::chr2:189849488..189849548,+	p@chr2:189849488..189849548 +
Hg19::chr3:100238112..100238123,+	p9@TMEM45A
Hg19::chr4:7436623..7436650,-	p1@PSAPL1
Hg19::chr5:132460176..132460179,-	p@chr5:132460176..132460179 -
Hg19::chr6:169582924..169582941,-	p1@uc011egv.1
Hg19::chr6:31106840..31106848,-	p1@PSORS1C2
Hg19::chr8:82373809..82373815,-	p1@FABP9

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0005882	intermediate filament	1.1208404948315e-59
GO:0045111	intermediate filament cytoskeleton	1.1208404948315e-59
GO:0044430	cytoskeletal part	3.9119482783705e-39
GO:0005856	cytoskeleton	5.76371606942739e-38
GO:0044446	intracellular organelle part	2.17698466243593e-29
GO:0044422	organelle part	2.25177511944484e-29
GO:0043232	intracellular non-membrane-bound organelle	7.68133773291025e-27
GO:0043228	non-membrane-bound organelle	7.68133773291025e-27
GO:0045095	keratin filament	1.45046114508371e-17
GO:0008544	epidermis development	2.26158647486084e-15
GO:0007398	ectoderm development	4.96550089454214e-15
GO:0009888	tissue development	1.54617141935801e-11
GO:0043229	intracellular organelle	6.11875480359721e-10
GO:0043226	organelle	6.11875480359721e-10
GO:0044424	intracellular part	1.04983647492565e-09
GO:0031424	keratinization	3.47712308664615e-08
GO:0009913	epidermal cell differentiation	1.22758567921542e-07
GO:0048730	epidermis morphogenesis	2.10050284994915e-07
GO:0005622	intracellular	3.24635649567415e-07
GO:0048729	tissue morphogenesis	7.45577359694037e-07
GO:0048513	organ development	7.940099712924e-06
GO:0032502	developmental process	9.57971456732683e-05
GO:0048731	system development	0.000170398828538472
GO:0048856	anatomical structure development	0.000251224646956548
GO:0007275	multicellular organismal development	0.000866833468931428
GO:0001533	cornified envelope	0.00280408857071443
GO:0009653	anatomical structure morphogenesis	0.00539239046622906
GO:0004231	insulysin activity	0.00774612961119495
GO:0044464	cell part	0.0149983939589835
GO:0005584	collagen type I	0.0201504240562489
GO:0008147	structural constituent of bone	0.0248826537274661
GO:0005200	structural constituent of cytoskeleton	0.0287101500655512
GO:0009898	internal side of plasma membrane	0.0332171421029089
GO:0032501	multicellular organismal process	0.0465018647410683

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	9.12e-12	180
fibroblast	7.18e-09	75

Uber Anatomy

Ontology term	p-value	n
organism subdivision	1.02e-14	365
multi-cellular organism	9.64e-13	659
surface structure	1.87e-12	95
mesenchyme	1.00e-11	238
entire embryonic mesenchyme	1.00e-11	238
trunk	3.26e-11	216
trunk mesenchyme	1.42e-10	143
endoderm-derived structure	3.94e-10	169
endoderm	3.94e-10	169
presumptive endoderm	3.94e-10	169
organ	6.65e-10	511
multi-tissue structure	7.27e-10	347
anatomical system	3.02e-09	625
anatomical group	4.83e-09	626
organ component layer	1.47e-08	57
integument	4.70e-08	45
integumental system	4.70e-08	45
digestive system	4.78e-08	155
digestive tract	4.78e-08	155
primitive gut	4.78e-08	155
embryo	1.51e-07	612
skin of body	2.57e-07	40
endo-epithelium	2.95e-07	82
embryonic structure	5.06e-07	605
developing anatomical structure	5.06e-07	605
germ layer	9.54e-07	604
embryonic tissue	9.54e-07	604
presumptive structure	9.54e-07	604
epiblast (generic)	9.54e-07	604

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---