Coexpression cluster:C2275

Full id: C2275_MCF7_breast_Hepatocyte_pancreatic_liver_parietal_temporal

Phase1 CAGE Peaks

Hg19::chr14:100437780..100437791,+	p10@EVL
Hg19::chr14:100437793..100437811,+	p8@EVL
Hg19::chr14:100437825..100437840,+	p9@EVL
Hg19::chr14:100437931..100437940,+	p17@EVL

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
organism subdivision	4.45e-19	365
neural tube	6.15e-19	57
neural rod	6.15e-19	57
future spinal cord	6.15e-19	57
neural keel	6.15e-19	57
central nervous system	3.45e-17	82
regional part of nervous system	4.00e-17	94
nervous system	4.00e-17	94
neural plate	1.69e-16	86
presumptive neural plate	1.69e-16	86
neurectoderm	9.60e-16	90
regional part of brain	1.04e-15	59
anterior neural tube	1.29e-15	42
brain	1.39e-15	69
future brain	1.39e-15	69
tube	1.44e-15	194
regional part of forebrain	4.07e-15	41
forebrain	4.07e-15	41
future forebrain	4.07e-15	41
anatomical conduit	1.32e-14	241
pre-chordal neural plate	4.81e-14	61
ectoderm-derived structure	1.10e-13	169
head	1.93e-13	123
telencephalon	2.31e-13	34
ectoderm	2.34e-13	173
presumptive ectoderm	2.34e-13	173
anterior region of body	2.39e-13	129
craniocervical region	2.39e-13	129
anatomical cluster	2.73e-13	286
cerebral hemisphere	6.75e-13	32
cell layer	6.86e-13	312
regional part of telencephalon	7.06e-13	33
gray matter	8.26e-13	34
brain grey matter	8.26e-13	34
epithelium	1.15e-12	309
adult organism	3.02e-11	115
cerebral cortex	7.77e-11	25
pallium	7.77e-11	25
neocortex	1.13e-10	20
regional part of cerebral cortex	1.29e-10	22
multi-tissue structure	8.03e-10	347
organ part	4.41e-07	219

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
E2F1#1869	4	4.90738921487932	0.00172402235736179	0.0106340167127633
E2F6#1876	4	5.01715573169739	0.0015780219347306	0.00995692561873665
EGR1#1958	4	4.98817909481014	0.00161501150007605	0.0101327758053853
HEY1#23462	4	4.04011104310571	0.0037530463691798	0.0185703515303345
MYC#4609	4	5.2222818716094	0.00134430939527274	0.00886409046864634
NRF1#4899	4	12.2102794477109	4.49717228915276e-05	0.000792709158998861
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0321578321675193
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0243731395725165
USF1#7391	4	6.36149927720796	0.000610501139914083	0.00507280838185114
USF2#7392	4	12.9921973850696	3.50833029870167e-05	0.000680547006066314

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.