MCL coexpression mm9:419

Phase1 CAGE Peaks

	Short description
Mm9::chr10:75411037..75411078,+	p1@Vpreb3
Mm9::chr10:75411080..75411098,+	p2@Vpreb3
Mm9::chr11:44388716..44388720,+	p@chr11:44388716..44388720 +
Mm9::chr12:115045984..115045990,-	p1@LOC100047361
Mm9::chr12:115707771..115707799,-	p1@ENSMUST00000109711
Mm9::chr17:8437904..8437915,+	p4@Ccr6
Mm9::chr17:8437919..8437957,+	p1@Ccr6
Mm9::chr1:87497443..87497454,+	p3@Gm2427 p3@Sp140
Mm9::chr2:99640370..99640374,+	p@chr2:99640370..99640374 +
Mm9::chr6:122503817..122503834,+	p1@Aicda
Mm9::chr6:67505591..67505606,+	p1@ENSMUST00000103302 p1@uc012enb.1
Mm9::chr6:68101848..68101850,+	p1@ENSMUST00000103318
Mm9::chr6:68424573..68424579,+	p@chr6:68424573..68424579 +
Mm9::chr6:68630341..68630348,+	p1@ENSMUST00000103329
Mm9::chr6:68889550..68889579,+	p1@ENSMUST00000103339
Mm9::chr6:70676952..70676959,-	p@chr6:70676952..70676959 -
Mm9::chr9:103351500..103351511,-	p6@Bfsp2
Mm9::chr9:70664786..70664801,-	p@chr9:70664786..70664801 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004126	cytidine deaminase activity	0.0361836203434129
GO:0004945	angiotensin type II receptor activity	0.0361836203434129
GO:0001595	angiotensin receptor activity	0.0361836203434129
GO:0016493	C-C chemokine receptor activity	0.0361836203434129
GO:0019957	C-C chemokine binding	0.0361836203434129
GO:0019239	deaminase activity	0.0361836203434129
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.0361836203434129
GO:0001637	G-protein chemoattractant receptor activity	0.0361836203434129
GO:0004950	chemokine receptor activity	0.0361836203434129
GO:0019956	chemokine binding	0.0361836203434129
GO:0005212	structural constituent of eye lens	0.0361836203434129

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
megakaryocyte progenitor cell	2.43e-23	6
megakaryocyte	2.43e-23	6
megakaryocyte-erythroid progenitor cell	2.19e-15	9
CD9-positive, CD41-positive megakaryocyte cell	3.59e-12	3
Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell	3.59e-12	3
Kit-positive megakaryocyte progenitor cell	3.59e-12	3
myeloid lineage restricted progenitor cell	1.78e-10	13
myeloid cell	2.12e-08	16
common myeloid progenitor	5.61e-07	19
hematopoietic lineage restricted progenitor cell	5.96e-07	25

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	2.44e-15	48
immune system	2.44e-15	48
lymphoid system	6.76e-13	3
spleen	2.54e-10	6
cavity lining	2.54e-10	6
serous membrane	2.54e-10	6
gastrointestinal system mesentery	2.54e-10	6
stomach region	2.54e-10	6
mesentery	2.54e-10	6
gastrointestinal system serosa	2.54e-10	6
mesentery of stomach	2.54e-10	6
gut mesentery	2.54e-10	6
dorsal mesentery	2.54e-10	6
dorsal mesogastrium	2.54e-10	6
peritoneal cavity	2.54e-10	6
spleen primordium	2.54e-10	6
hematopoietic system	4.96e-10	45
blood island	4.96e-10	45
gut-associated lymphoid tissue	2.80e-09	2
mucosa-associated lymphoid tissue	2.80e-09	2
lymphoid tissue	2.80e-09	2
intraembryonic coelom	3.10e-09	10
bone marrow	2.12e-08	16

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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