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Coexpression cluster:C3753: Difference between revisions

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|full_id=C3753_parietal_brain_occipital_Mesenchymal_cerebellum_Neural_temporal
|full_id=C3753_parietal_brain_occipital_Mesenchymal_cerebellum_Neural_temporal
|id=C3753
|id=C3753
|ontology_enrichment_celltype=CL:0000055!3.41e-32!180;CL:0000057!4.19e-16!75;CL:0000680!1.02e-12!57;CL:0000056!1.02e-12!57;CL:0000355!1.02e-12!57;CL:0000187!4.63e-12!54;CL:0000393!3.63e-11!60;CL:0000211!3.63e-11!60;CL:0000183!8.98e-11!59;CL:0000192!4.51e-10!42;CL:0000514!4.51e-10!42;CL:0000359!7.17e-08!32;CL:0002620!8.62e-08!23;CL:0000222!2.13e-07!119
|ontology_enrichment_celltype=CL:0000057!1.12e-16!76;CL:0000055!3.38e-15!106;CL:0000680!3.75e-13!58;CL:0000056!3.75e-13!58;CL:0000355!3.75e-13!58;CL:0000187!1.79e-12!55;CL:0000183!5.78e-12!59;CL:0000393!1.27e-11!61;CL:0000211!1.27e-11!61;CL:0000192!7.64e-11!43;CL:0000514!7.64e-11!43;CL:0000359!1.99e-08!32;CL:0002620!7.75e-08!23;CL:0000222!2.86e-07!121
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000475!7.56e-29!365;UBERON:0001017!1.78e-25!82;UBERON:0000924!5.30e-25!173;UBERON:0006601!5.30e-25!173;UBERON:0000073!6.88e-25!94;UBERON:0001016!6.88e-25!94;UBERON:0001049!1.03e-24!57;UBERON:0005068!1.03e-24!57;UBERON:0006241!1.03e-24!57;UBERON:0007135!1.03e-24!57;UBERON:0000955!3.23e-24!69;UBERON:0006238!3.23e-24!69;UBERON:0004121!4.67e-24!169;UBERON:0005743!8.14e-24!86;UBERON:0000033!9.66e-23!123;UBERON:0002616!1.39e-22!59;UBERON:0002346!1.96e-21!90;UBERON:0000153!6.19e-21!129;UBERON:0007811!6.19e-21!129;UBERON:0003075!1.43e-20!86;UBERON:0007284!1.43e-20!86;UBERON:0002780!8.46e-18!41;UBERON:0001890!8.46e-18!41;UBERON:0006240!8.46e-18!41;UBERON:0003080!2.17e-17!42;UBERON:0001893!5.65e-17!34;UBERON:0000119!1.69e-16!312;UBERON:0000483!1.80e-16!309;UBERON:0002791!2.12e-16!33;UBERON:0002020!2.73e-16!34;UBERON:0003528!2.73e-16!34;UBERON:0001869!9.51e-16!32;UBERON:0000914!2.96e-15!83;UBERON:0002329!2.96e-15!83;UBERON:0003077!2.96e-15!83;UBERON:0003059!2.96e-15!83;UBERON:0007282!2.96e-15!83;UBERON:0009618!2.96e-15!83;UBERON:0007285!2.96e-15!83;UBERON:0003056!3.16e-14!61;UBERON:0004290!2.38e-13!70;UBERON:0004111!2.68e-13!241;UBERON:0000956!5.06e-13!25;UBERON:0000203!5.06e-13!25;UBERON:0000025!5.86e-13!194;UBERON:0007023!1.32e-12!115;UBERON:0000477!1.45e-12!286;UBERON:0000481!2.03e-12!347;UBERON:0002619!2.28e-12!22;UBERON:0001134!3.99e-12!61;UBERON:0002036!3.99e-12!61;UBERON:0003082!3.99e-12!61;UBERON:0002385!8.92e-12!63;UBERON:0001015!8.92e-12!63;UBERON:0000383!8.92e-12!63;UBERON:0001950!1.49e-11!20;UBERON:0000486!2.68e-11!82;UBERON:0000468!1.01e-10!659;UBERON:0003102!5.64e-09!95;UBERON:0001637!5.75e-09!42;UBERON:0003509!5.75e-09!42;UBERON:0004572!5.75e-09!42;UBERON:0003076!1.42e-08!15;UBERON:0003057!1.42e-08!15;UBERON:0004573!1.76e-08!33;UBERON:0004571!1.76e-08!33;UBERON:0000467!1.94e-08!625;UBERON:0000480!3.22e-08!626;UBERON:0002050!7.15e-08!605;UBERON:0005423!7.15e-08!605;UBERON:0004732!7.57e-08!13;UBERON:0000923!1.05e-07!604;UBERON:0005291!1.05e-07!604;UBERON:0006598!1.05e-07!604;UBERON:0002532!1.05e-07!604;UBERON:0002199!2.50e-07!45;UBERON:0002416!2.50e-07!45;UBERON:0000479!2.89e-07!787;UBERON:0004733!3.46e-07!12;UBERON:0002028!3.46e-07!12;UBERON:0007277!3.46e-07!12;UBERON:0000922!4.76e-07!612;UBERON:0001981!6.44e-07!60;UBERON:0007500!6.44e-07!60;UBERON:0004537!6.44e-07!60;UBERON:0006965!6.44e-07!60;UBERON:0002097!7.35e-07!40
|ontology_enrichment_uberon=UBERON:0001016!5.58e-27!89;UBERON:0004121!1.54e-26!171;UBERON:0000924!1.54e-26!171;UBERON:0006601!1.54e-26!171;UBERON:0001017!4.54e-26!81;UBERON:0001049!2.38e-25!56;UBERON:0005068!2.38e-25!56;UBERON:0006241!2.38e-25!56;UBERON:0007135!2.38e-25!56;UBERON:0000955!5.20e-25!68;UBERON:0006238!5.20e-25!68;UBERON:0000073!6.69e-24!53;UBERON:0002616!6.69e-24!53;UBERON:0010314!1.12e-23!132;UBERON:0002346!5.95e-23!86;UBERON:0003075!6.11e-22!82;UBERON:0007284!6.11e-22!82;UBERON:0010371!6.49e-21!104;UBERON:0002780!3.79e-18!41;UBERON:0001890!3.79e-18!41;UBERON:0003080!3.79e-18!41;UBERON:0006240!3.79e-18!41;UBERON:0001893!2.60e-17!34;UBERON:0000119!3.14e-17!309;UBERON:0000483!3.28e-17!306;UBERON:0003528!9.18e-17!34;UBERON:0002020!9.18e-17!34;UBERON:0002791!4.19e-16!32;UBERON:0001869!5.13e-16!32;UBERON:0000477!1.45e-15!373;UBERON:0003056!8.74e-15!61;UBERON:0007524!1.80e-14!73;UBERON:0000481!2.24e-14!342;UBERON:0003077!3.82e-14!72;UBERON:0007285!3.82e-14!72;UBERON:0004111!4.04e-14!240;UBERON:0002329!1.20e-13!71;UBERON:0003059!1.20e-13!71;UBERON:0007282!1.20e-13!71;UBERON:0004290!1.20e-13!71;UBERON:0009618!1.20e-13!71;UBERON:0000025!1.83e-13!192;UBERON:0000956!4.12e-13!25;UBERON:0000203!4.12e-13!25;UBERON:0001134!1.21e-12!62;UBERON:0002036!1.21e-12!62;UBERON:0003082!1.21e-12!62;UBERON:0002619!1.68e-12!22;UBERON:0011216!1.76e-12!223;UBERON:0002385!2.30e-12!64;UBERON:0001015!2.30e-12!64;UBERON:0000383!2.30e-12!64;UBERON:0001950!1.16e-11!20;UBERON:0007023!1.21e-11!114;UBERON:0000468!2.81e-11!656;UBERON:0000486!6.76e-11!83;UBERON:0007503!1.12e-10!78;UBERON:0001637!1.16e-09!42;UBERON:0003509!1.16e-09!42;UBERON:0004572!1.16e-09!42;UBERON:0000467!1.16e-09!624;UBERON:0000480!1.90e-09!625;UBERON:0000923!2.16e-09!560;UBERON:0010316!2.16e-09!560;UBERON:0005291!2.16e-09!560;UBERON:0006598!2.16e-09!560;UBERON:0010317!2.16e-09!560;UBERON:0002532!2.16e-09!560;UBERON:0002050!2.45e-09!564;UBERON:0004573!3.43e-09!33;UBERON:0004571!3.43e-09!33;UBERON:0000479!1.24e-08!773;UBERON:0003076!2.07e-08!15;UBERON:0003057!2.07e-08!15;UBERON:0003102!2.11e-08!99;UBERON:0004732!1.05e-07!13;UBERON:0002199!1.11e-07!46;UBERON:0002416!1.11e-07!46;UBERON:0002097!1.73e-07!41;UBERON:0005256!1.90e-07!122;UBERON:0007500!3.06e-07!59;UBERON:0001981!3.06e-07!59;UBERON:0004537!3.06e-07!59;UBERON:0006965!3.06e-07!59;UBERON:0005423!4.28e-07!581;UBERON:0004733!4.72e-07!12;UBERON:0002028!4.72e-07!12;UBERON:0007277!4.72e-07!12;UBERON:0002049!4.75e-07!78;UBERON:0007798!4.75e-07!78;UBERON:0000490!8.89e-07!148
|tf_chipseq_enrich=CTBP2#1488;3:62.7170003393281:4.049570681927e-06:0.000129654540910415!CTCF#10664;3:5.36025637307503:0.006492509252767:0.0279386557004422!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0322095769335104!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109391213636571!ZZZ3#26009;2:159.608808290155:5.21262599582697e-05:0.000886647306804842
|tf_chipseq_enrich=CTBP2#1488;3:62.7170003393281:4.049570681927e-06:0.000129654540910415!CTCF#10664;3:5.36025637307503:0.006492509252767:0.0279386557004422!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0322095769335104!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109391213636571!ZZZ3#26009;2:159.608808290155:5.21262599582697e-05:0.000886647306804842
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}}
}}

Revision as of 15:23, 19 October 2012


Full id: C3753_parietal_brain_occipital_Mesenchymal_cerebellum_Neural_temporal



Phase1 CAGE Peaks

Hg19::chr19:13134154..13134180,+p@chr19:13134154..13134180
+
Hg19::chr19:13134191..13134214,+p@chr19:13134191..13134214
+
Hg19::chr19:13134457..13134462,+p5@NFIX


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
nervous system5.58e-2789
ectoderm-derived structure1.54e-26171
ectoderm1.54e-26171
presumptive ectoderm1.54e-26171
central nervous system4.54e-2681
neural tube2.38e-2556
neural rod2.38e-2556
future spinal cord2.38e-2556
neural keel2.38e-2556
brain5.20e-2568
future brain5.20e-2568
regional part of nervous system6.69e-2453
regional part of brain6.69e-2453
structure with developmental contribution from neural crest1.12e-23132
neurectoderm5.95e-2386
neural plate6.11e-2282
presumptive neural plate6.11e-2282
ecto-epithelium6.49e-21104
regional part of forebrain3.79e-1841
forebrain3.79e-1841
anterior neural tube3.79e-1841
future forebrain3.79e-1841
telencephalon2.60e-1734
cell layer3.14e-17309
epithelium3.28e-17306
brain grey matter9.18e-1734
gray matter9.18e-1734
regional part of telencephalon4.19e-1632
cerebral hemisphere5.13e-1632
anatomical cluster1.45e-15373
pre-chordal neural plate8.74e-1561
dense mesenchyme tissue1.80e-1473
multi-tissue structure2.24e-14342
paraxial mesoderm3.82e-1472
presumptive paraxial mesoderm3.82e-1472
anatomical conduit4.04e-14240
somite1.20e-1371
presomitic mesoderm1.20e-1371
presumptive segmental plate1.20e-1371
dermomyotome1.20e-1371
trunk paraxial mesoderm1.20e-1371
tube1.83e-13192
cerebral cortex4.12e-1325
pallium4.12e-1325
skeletal muscle tissue1.21e-1262
striated muscle tissue1.21e-1262
myotome1.21e-1262
regional part of cerebral cortex1.68e-1222
organ system subdivision1.76e-12223
muscle tissue2.30e-1264
musculature2.30e-1264
musculature of body2.30e-1264
neocortex1.16e-1120
adult organism1.21e-11114
multi-cellular organism2.81e-11656
multilaminar epithelium6.76e-1183
epithelial vesicle1.12e-1078
artery1.16e-0942
arterial blood vessel1.16e-0942
arterial system1.16e-0942
anatomical system1.16e-09624
anatomical group1.90e-09625
germ layer2.16e-09560
germ layer / neural crest2.16e-09560
embryonic tissue2.16e-09560
presumptive structure2.16e-09560
germ layer / neural crest derived structure2.16e-09560
epiblast (generic)2.16e-09560
embryonic structure2.45e-09564
systemic artery3.43e-0933
systemic arterial system3.43e-0933
tissue1.24e-08773
posterior neural tube2.07e-0815
chordal neural plate2.07e-0815
surface structure2.11e-0899
segmental subdivision of nervous system1.05e-0713
integument1.11e-0746
integumental system1.11e-0746
skin of body1.73e-0741
trunk mesenchyme1.90e-07122
epithelial tube open at both ends3.06e-0759
blood vessel3.06e-0759
blood vasculature3.06e-0759
vascular cord3.06e-0759
developing anatomical structure4.28e-07581
segmental subdivision of hindbrain4.72e-0712


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488362.71700033932814.049570681927e-060.000129654540910415
CTCF#1066435.360256373075030.0064925092527670.0279386557004422
E2F6#187635.017155731697390.00791769806886330.0322095769335104
ZNF263#1012738.221841637010680.001799043925565870.0109391213636571
ZZZ3#260092159.6088082901555.21262599582697e-050.000886647306804842



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.