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Coexpression cluster:C4415: Difference between revisions

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|full_id=C4415_caudate_putamen_cord_Natural_CD8_nucleus_Basophils
|full_id=C4415_caudate_putamen_cord_Natural_CD8_nucleus_Basophils
|id=C4415
|id=C4415
|ontology_enrichment_celltype=CL:0000542!1.62e-21!53;CL:0000051!1.62e-21!53;CL:0000838!2.08e-21!52;CL:0000738!1.99e-19!140;CL:0000037!5.24e-19!172;CL:0000566!5.24e-19!172;CL:0000988!1.45e-18!182;CL:0002032!2.00e-16!165;CL:0000837!2.00e-16!165;CL:0002087!2.19e-15!119;CL:0002031!5.50e-15!124;CL:0000084!1.56e-11!25;CL:0000827!1.56e-11!25;CL:0000791!2.72e-11!18;CL:0000789!2.72e-11!18;CL:0002420!2.72e-11!18;CL:0002419!2.72e-11!18;CL:0000790!2.72e-11!18;CL:0000945!3.93e-09!24;CL:0000826!3.93e-09!24;CL:0000625!2.48e-08!11
|ontology_enrichment_celltype=CL:0000542!1.18e-22!53;CL:0000051!1.18e-22!53;CL:0000838!1.72e-22!52;CL:0002242!4.38e-21!55;CL:0000738!6.18e-17!136;CL:0000037!8.43e-16!168;CL:0000566!8.43e-16!168;CL:0000988!1.12e-15!177;CL:0002087!6.64e-14!115;CL:0000084!9.06e-14!25;CL:0000827!9.06e-14!25;CL:0002032!4.12e-13!161;CL:0000837!4.12e-13!161;CL:0000791!6.97e-13!18;CL:0000789!6.97e-13!18;CL:0002420!6.97e-13!18;CL:0002419!6.97e-13!18;CL:0000790!6.97e-13!18;CL:0002031!3.86e-12!120;CL:0000625!3.07e-09!11;CL:0000945!5.45e-08!24;CL:0000826!5.45e-08!24
|ontology_enrichment_disease=
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0007023!3.11e-43!115;UBERON:0001049!1.08e-23!57;UBERON:0005068!1.08e-23!57;UBERON:0006241!1.08e-23!57;UBERON:0007135!1.08e-23!57;UBERON:0003080!2.48e-23!42;UBERON:0002780!5.80e-23!41;UBERON:0001890!5.80e-23!41;UBERON:0006240!5.80e-23!41;UBERON:0001017!2.30e-20!82;UBERON:0005743!7.63e-20!86;UBERON:0001893!1.80e-19!34;UBERON:0002616!4.83e-19!59;UBERON:0002020!6.72e-19!34;UBERON:0003528!6.72e-19!34;UBERON:0002791!8.33e-19!33;UBERON:0000955!8.51e-19!69;UBERON:0006238!8.51e-19!69;UBERON:0001869!1.47e-18!32;UBERON:0000073!4.08e-18!94;UBERON:0001016!4.08e-18!94;UBERON:0003075!2.11e-17!86;UBERON:0007284!2.11e-17!86;UBERON:0003056!1.20e-15!61;UBERON:0002619!2.92e-15!22;UBERON:0002346!3.04e-15!90;UBERON:0001950!5.46e-14!20;UBERON:0000956!1.04e-13!25;UBERON:0000203!1.04e-13!25;UBERON:0000153!1.33e-08!129;UBERON:0007811!1.33e-08!129;UBERON:0000178!2.58e-08!15;UBERON:0000179!2.58e-08!15;UBERON:0000463!2.58e-08!15;UBERON:0002420!1.39e-07!9;UBERON:0007245!1.39e-07!9;UBERON:0010009!1.39e-07!9;UBERON:0010011!1.39e-07!9;UBERON:0000454!1.39e-07!9;UBERON:0000033!5.41e-07!123
|ontology_enrichment_uberon=UBERON:0007023!1.30e-42!114;UBERON:0002780!2.54e-27!41;UBERON:0001890!2.54e-27!41;UBERON:0003080!2.54e-27!41;UBERON:0006240!2.54e-27!41;UBERON:0001049!2.56e-27!56;UBERON:0005068!2.56e-27!56;UBERON:0006241!2.56e-27!56;UBERON:0007135!2.56e-27!56;UBERON:0000073!4.22e-26!53;UBERON:0002616!4.22e-26!53;UBERON:0001893!6.73e-24!34;UBERON:0003528!2.38e-23!34;UBERON:0002020!2.38e-23!34;UBERON:0001869!8.43e-23!32;UBERON:0002791!1.33e-22!32;UBERON:0001017!2.45e-22!81;UBERON:0000955!5.77e-22!68;UBERON:0006238!5.77e-22!68;UBERON:0001016!6.40e-21!89;UBERON:0003075!6.88e-20!82;UBERON:0007284!6.88e-20!82;UBERON:0003056!6.16e-19!61;UBERON:0002619!1.63e-18!22;UBERON:0002346!7.44e-18!86;UBERON:0000956!4.26e-17!25;UBERON:0000203!4.26e-17!25;UBERON:0001950!5.39e-17!20;UBERON:0010371!7.46e-14!104;UBERON:0002420!1.22e-08!9;UBERON:0007245!1.22e-08!9;UBERON:0010009!1.22e-08!9;UBERON:0010011!1.22e-08!9;UBERON:0000454!1.22e-08!9;UBERON:0010314!1.29e-08!132;UBERON:0000178!1.80e-08!15;UBERON:0000179!1.80e-08!15;UBERON:0000463!1.80e-08!15;UBERON:0000125!1.02e-07!9;UBERON:0002308!1.02e-07!9;UBERON:0009663!4.62e-07!7;UBERON:0011216!9.96e-07!223
|tf_chipseq_enrich=CCNT2#905;3:6.33620157696263:0.00393075003576489:0.0190754891959133!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0326941264126215!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0323709715644554!EBF1#1879;3:8.906466846569:0.0014152328356098:0.00918160654231907!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0321898911427441!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128548262233359!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0277813542420314!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0247515332253362!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0140697743758443!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109826016215907
|tf_chipseq_enrich=CCNT2#905;3:6.33620157696263:0.00393075003576489:0.0190754891959133!E2F1#1869;3:4.90738921487932:0.00846098534723939:0.0326941264126215!E2F6#1876;3:5.01715573169739:0.0079176980688633:0.0323709715644554!EBF1#1879;3:8.906466846569:0.0014152328356098:0.00918160654231907!EGR1#1958;3:4.98817909481014:0.00805648813738344:0.0321898911427441!IRF1#3659;3:7.6371637535639:0.00224469274729724:0.0128548262233359!SIN3A#25942;3:5.40888472681514:0.00631896197799152:0.0277813542420314!SP1#6667;3:5.6983813781409:0.00540396270171217:0.0247515332253362!ZBTB7A#51341;3:7.3519093078759:0.00251625586028227:0.0140697743758443!ZNF263#10127;3:8.22184163701068:0.00179904392556587:0.0109826016215907
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}}
}}

Revision as of 15:56, 19 October 2012


Full id: C4415_caudate_putamen_cord_Natural_CD8_nucleus_Basophils



Phase1 CAGE Peaks

Hg19::chr4:42658957..42658974,-p5@ATP8A1
Hg19::chr4:42658982..42659008,-p3@ATP8A1
Hg19::chr4:42659011..42659029,-p4@ATP8A1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism1.30e-42114
regional part of forebrain2.54e-2741
forebrain2.54e-2741
anterior neural tube2.54e-2741
future forebrain2.54e-2741
neural tube2.56e-2756
neural rod2.56e-2756
future spinal cord2.56e-2756
neural keel2.56e-2756
regional part of nervous system4.22e-2653
regional part of brain4.22e-2653
telencephalon6.73e-2434
brain grey matter2.38e-2334
gray matter2.38e-2334
cerebral hemisphere8.43e-2332
regional part of telencephalon1.33e-2232
central nervous system2.45e-2281
brain5.77e-2268
future brain5.77e-2268
nervous system6.40e-2189
neural plate6.88e-2082
presumptive neural plate6.88e-2082
pre-chordal neural plate6.16e-1961
regional part of cerebral cortex1.63e-1822
neurectoderm7.44e-1886
cerebral cortex4.26e-1725
pallium4.26e-1725
neocortex5.39e-1720
ecto-epithelium7.46e-14104
basal ganglion1.22e-089
nuclear complex of neuraxis1.22e-089
aggregate regional part of brain1.22e-089
collection of basal ganglia1.22e-089
cerebral subcortex1.22e-089
structure with developmental contribution from neural crest1.29e-08132
blood1.80e-0815
haemolymphatic fluid1.80e-0815
organism substance1.80e-0815
neural nucleus1.02e-079
nucleus of brain1.02e-079
telencephalic nucleus4.62e-077
organ system subdivision9.96e-07223


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190754891959133
E2F1#186934.907389214879320.008460985347239390.0326941264126215
E2F6#187635.017155731697390.00791769806886330.0323709715644554
EBF1#187938.9064668465690.00141523283560980.00918160654231907
EGR1#195834.988179094810140.008056488137383440.0321898911427441
IRF1#365937.63716375356390.002244692747297240.0128548262233359
SIN3A#2594235.408884726815140.006318961977991520.0277813542420314
SP1#666735.69838137814090.005403962701712170.0247515332253362
ZBTB7A#5134137.35190930787590.002516255860282270.0140697743758443
ZNF263#1012738.221841637010680.001799043925565870.0109826016215907



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.