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Coexpression cluster:C37: Difference between revisions

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|pathway_enrichment=5.68771750906091e-05;0.0180016259161778;3;27;Collecting duct acid secretion (KEGG):04966!2.96716142307693e-21;1.8782131808077e-18;14;89;Salivary secretion (KEGG):04970!0.000124503843645929;0.0262703110092911;7;401;Transmembrane transport of small molecules (Reactome):REACT_15518
|pathway_enrichment=5.68771750906091e-05;0.0180016259161778;3;27;Collecting duct acid secretion (KEGG):04966!2.96716142307693e-21;1.8782131808077e-18;14;89;Salivary secretion (KEGG):04970!0.000124503843645929;0.0262703110092911;7;401;Transmembrane transport of small molecules (Reactome):REACT_15518
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}}

Revision as of 13:11, 26 November 2012


Full id: C37_salivary_submaxillary_parotid_seminal_tongue_ductus_trachea



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
5.68771750906091e-050.0180016259161778327Collecting duct acid secretion (KEGG):04966
2.96716142307693e-211.8782131808077e-181489Salivary secretion (KEGG):04970
0.0001245038436459290.02627031100929117401Transmembrane transport of small molecules (Reactome):REACT_15518



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0046903secretion0.000143037779776816
GO:0031214biomineral formation0.000143037779776816
GO:0001503ossification0.000143037779776816
GO:0004869cysteine protease inhibitor activity0.000143037779776816
GO:0046849bone remodeling0.000143037779776816
GO:0007588excretion0.000143037779776816
GO:0048771tissue remodeling0.000175708979982803
GO:0016324apical plasma membrane0.000751494979317117
GO:0045177apical part of cell0.00169673922733692
GO:0009888tissue development0.00169711188910609
GO:0022892substrate-specific transporter activity0.00169711188910609
GO:0006885regulation of pH0.0019057807084014
GO:0001501skeletal development0.00264035699267428
GO:0006811ion transport0.00264035699267428
GO:0022857transmembrane transporter activity0.00271145939367049
GO:0033176proton-transporting V-type ATPase complex0.0028474390787468
GO:0016471vacuolar proton-transporting V-type ATPase complex0.0028474390787468
GO:0022891substrate-specific transmembrane transporter activity0.00538704337765753
GO:0015075ion transmembrane transporter activity0.00719916602517181
GO:0006812cation transport0.00719916602517181
GO:0050832defense response to fungus0.00719916602517181
GO:0009620response to fungus0.0176488723943194
GO:0006821chloride transport0.0179235375774165
GO:0008509anion transmembrane transporter activity0.0193548222625774
GO:0004857enzyme inhibitor activity0.0276217274943027
GO:0051234establishment of localization0.0303073119039209
GO:0004866endopeptidase inhibitor activity0.0303073119039209
GO:0048856anatomical structure development0.0303073119039209
GO:0015698inorganic anion transport0.0303073119039209
GO:0006805xenobiotic metabolic process0.0303073119039209
GO:0030414protease inhibitor activity0.0303073119039209
GO:0050801ion homeostasis0.0303073119039209
GO:0022804active transmembrane transporter activity0.0303073119039209
GO:0044421extracellular region part0.0303073119039209
GO:0042581specific granule0.0303073119039209
GO:0048388endosomal lumen acidification0.0303073119039209
GO:0009410response to xenobiotic stimulus0.0304903155620692
GO:0007605sensory perception of sound0.031844758974454
GO:0050954sensory perception of mechanical stimulus0.031844758974454
GO:0065008regulation of biological quality0.0350725703150292
GO:0005247voltage-gated chloride channel activity0.0380105546104302
GO:0048878chemical homeostasis0.0380105546104302
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism0.0380105546104302
GO:0022844voltage-gated anion channel activity0.0390687960623424
GO:0006820anion transport0.0390687960623424
GO:0005615extracellular space0.0390687960623424
GO:0044463cell projection part0.0390687960623424
GO:0046541saliva secretion0.0390687960623424
GO:0000301retrograde transport, vesicle recycling within Golgi0.0390687960623424
GO:0042637catagen0.0390687960623424
GO:0016889endodeoxyribonuclease activity, producing 3'-phosphomonoesters0.0390687960623424
GO:0004531deoxyribonuclease II activity0.0390687960623424
GO:0008761UDP-N-acetylglucosamine 2-epimerase activity0.0390687960623424
GO:0008511sodium:potassium:chloride symporter activity0.0390687960623424
GO:0046848hydroxyapatite binding0.0390687960623424
GO:0009384N-acylmannosamine kinase activity0.0390687960623424
GO:0000042protein targeting to Golgi0.0390687960623424
GO:0017158regulation of calcium ion-dependent exocytosis0.0390687960623424
GO:0051179localization0.0449551098642048
GO:0042221response to chemical stimulus0.0497249727298682
GO:0003883CTP synthase activity0.0497249727298682
GO:0035253ciliary rootlet0.0497249727298682
GO:0009397folic acid and derivative catabolic process0.0497249727298682
GO:0006824cobalt ion transport0.0497249727298682
GO:0006054N-acetylneuraminate metabolic process0.0497249727298682
GO:0015087cobalt ion transmembrane transporter activity0.0497249727298682
GO:000925810-formyltetrahydrofolate catabolic process0.0497249727298682
GO:000925610-formyltetrahydrofolate metabolic process0.0497249727298682



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
major salivary gland2.34e-792
saliva-secreting gland8.15e-606
gland of oral region8.15e-606
gland of foregut8.15e-606
oral gland8.15e-606
oral cavity8.15e-606
submandibular gland9.91e-411
submandibular gland primordium9.91e-411
parotid gland1.48e-401
cheek1.48e-401
parotid gland primordium1.48e-401
gland of gut2.40e-3610
oral opening2.19e-2922
mouth1.67e-2229
stomodeum1.67e-2229
midface4.66e-212
open tracheal system trachea6.96e-212
orifice2.74e-1836
tongue1.83e-143
gustatory system1.83e-143
future tongue1.83e-143
respiratory system5.20e-1474
subdivision of head1.22e-1349
exocrine gland2.30e-1231
exocrine system2.30e-1231
head5.06e-1256
foregut5.13e-1287
anterior region of body6.33e-1162
craniocervical region6.33e-1162
adult organism2.58e-09114
subdivision of digestive tract6.01e-09118
digestive system2.16e-07145
digestive tract2.16e-07145
primitive gut2.16e-07145
anatomical space2.45e-0795
surface structure4.54e-0799
trachea6.39e-077
respiratory airway6.39e-077
gland7.38e-0759
endoderm-derived structure9.48e-07160
endoderm9.48e-07160
presumptive endoderm9.48e-07160


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data