Coexpression cluster:C4024

Full id: C4024_small_argyrophil_merkel_gastrointestinal_cervical_neuroblastoma_smallcell

Phase1 CAGE Peaks

Hg19::chr20:32150185..32150230,+	p3@CBFA2T2
Hg19::chr20:32150291..32150306,+	p7@CBFA2T2
Hg19::chr20:32150316..32150339,+	p4@CBFA2T2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
nervous system	2.41e-35	89
neural tube	5.17e-35	56
neural rod	5.17e-35	56
future spinal cord	5.17e-35	56
neural keel	5.17e-35	56
central nervous system	8.60e-34	81
regional part of nervous system	1.54e-32	53
regional part of brain	1.54e-32	53
telencephalon	3.55e-28	34
brain grey matter	4.71e-28	34
gray matter	4.71e-28	34
regional part of forebrain	2.95e-27	41
forebrain	2.95e-27	41
anterior neural tube	2.95e-27	41
future forebrain	2.95e-27	41
brain	7.20e-27	68
future brain	7.20e-27	68
adult organism	4.52e-26	114
neurectoderm	5.42e-26	86
regional part of telencephalon	1.44e-24	32
cerebral hemisphere	1.74e-24	32
neural plate	4.30e-24	82
presumptive neural plate	4.30e-24	82
organ system subdivision	2.91e-22	223
ectoderm-derived structure	2.74e-21	171
ectoderm	2.74e-21	171
presumptive ectoderm	2.74e-21	171
ecto-epithelium	3.39e-21	104
regional part of cerebral cortex	3.67e-21	22
cerebral cortex	8.59e-21	25
pallium	8.59e-21	25
neocortex	1.06e-20	20
pre-chordal neural plate	3.14e-19	61
structure with developmental contribution from neural crest	3.27e-14	132
brainstem	4.78e-14	6
anatomical cluster	1.65e-09	373
gyrus	5.46e-09	6
posterior neural tube	7.40e-09	15
chordal neural plate	7.40e-09	15
neural nucleus	1.12e-08	9
nucleus of brain	1.12e-08	9
organ part	1.48e-08	218
medulla oblongata	6.71e-08	3
myelencephalon	6.71e-08	3
future myelencephalon	6.71e-08	3
temporal lobe	6.95e-08	6
pons	8.09e-08	3
parietal lobe	1.19e-07	5
uterine cervix	6.16e-07	6
neck of organ	6.16e-07	6

Disease

Ontology term	p-value	n
neuroectodermal tumor	8.89e-09	10
neuroendocrine tumor	3.47e-07	6

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CEBPB#1051	3	7.97114762582482	0.00197418705528856	0.0115340189006087
EP300#2033	3	6.7739417262232	0.00321688050010379	0.0167656960202775
FOSL2#2355	3	16.9302006045617	0.000206016205317162	0.00243285012066023
FOXA1#3169	3	11.0814197493855	0.00073475527569867	0.00581958943111583
FOXA2#3170	3	24.6304637526652	6.68983856509345e-05	0.001072911624539
GATA2#2624	3	12.744931733554	0.000482952770428379	0.00437194282662473
GATA3#2625	3	27.236516357206	4.94721007899563e-05	0.00085232872556949
HDAC2#3066	3	13.4156202366263	0.000414076139985721	0.00391647328237355
JUN#3725	3	12.5128291923363	0.000510331399272625	0.00444747171300348
JUND#3727	3	6.99466394187103	0.00292184504273499	0.0156980592838212
RAD21#5885	3	10.3550338954563	0.000900491207356542	0.00664873815518627
REST#5978	3	9.65002871612802	0.00111263624711459	0.00768739196959517
RFX5#5993	3	12.0479108271951	0.000571724605031258	0.00485173852481186
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0190569065767964

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.