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Coexpression cluster:C2506: Difference between revisions

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{{Coexpression_clusters
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|id=C2506
|ontology_enrichment_celltype=CL:0002321!9.71e-18!248;CL:0000220!3.90e-17!246;CL:0000066!2.58e-16!254;CL:0000133!1.01e-11!59;CL:0000213!5.61e-11!57;CL:0000215!5.61e-11!57;CL:0000222!8.22e-11!119;CL:0000221!2.59e-10!71;CL:0002319!2.01e-08!25;CL:0000076!3.63e-08!62;CL:0002078!1.04e-07!44;CL:0000333!5.31e-07!41
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000073!5.24e-25!94;UBERON:0001016!5.24e-25!94;UBERON:0005743!7.75e-25!86;UBERON:0001017!2.60e-24!82;UBERON:0000119!1.39e-21!312;UBERON:0002346!1.79e-21!90;UBERON:0000483!2.72e-21!309;UBERON:0003056!1.42e-20!61;UBERON:0003075!2.33e-20!86;UBERON:0007284!2.33e-20!86;UBERON:0000477!6.00e-20!286;UBERON:0000955!6.76e-20!69;UBERON:0006238!6.76e-20!69;UBERON:0000025!9.01e-20!194;UBERON:0002780!4.77e-19!41;UBERON:0001890!4.77e-19!41;UBERON:0006240!4.77e-19!41;UBERON:0001893!5.56e-19!34;UBERON:0001869!6.51e-19!32;UBERON:0002020!9.42e-19!34;UBERON:0003528!9.42e-19!34;UBERON:0004111!1.23e-18!241;UBERON:0002791!2.23e-18!33;UBERON:0003080!3.41e-18!42;UBERON:0001049!6.85e-18!57;UBERON:0005068!6.85e-18!57;UBERON:0006241!6.85e-18!57;UBERON:0007135!6.85e-18!57;UBERON:0000924!1.50e-17!173;UBERON:0006601!1.50e-17!173;UBERON:0002616!1.28e-16!59;UBERON:0004121!1.51e-16!169;UBERON:0000033!2.32e-15!123;UBERON:0000475!4.57e-15!365;UBERON:0000481!6.98e-15!347;UBERON:0000956!1.27e-14!25;UBERON:0000203!1.27e-14!25;UBERON:0000153!2.79e-13!129;UBERON:0007811!2.79e-13!129;UBERON:0002619!2.88e-13!22;UBERON:0000922!4.03e-12!612;UBERON:0001950!4.77e-12!20;UBERON:0000064!2.84e-11!219;UBERON:0000468!7.41e-11!659;UBERON:0002050!1.46e-10!605;UBERON:0005423!1.46e-10!605;UBERON:0000923!2.48e-10!604;UBERON:0005291!2.48e-10!604;UBERON:0006598!2.48e-10!604;UBERON:0002532!2.48e-10!604;UBERON:0003064!2.08e-08!37;UBERON:0002049!5.61e-08!79;UBERON:0007798!5.61e-08!79;UBERON:0000467!9.87e-08!625;UBERON:0000480!1.41e-07!626;UBERON:0006914!1.82e-07!25;UBERON:0001637!3.26e-07!42;UBERON:0003509!3.26e-07!42;UBERON:0004572!3.26e-07!42;UBERON:0000487!6.08e-07!22;UBERON:0006554!7.15e-07!44;UBERON:0001981!7.23e-07!60;UBERON:0007500!7.23e-07!60;UBERON:0004537!7.23e-07!60;UBERON:0006965!7.23e-07!60
}}

Latest revision as of 12:07, 17 September 2013


Full id: C2506_putamen_caudate_nucleus_temporal_amygdala_insula_frontal



Phase1 CAGE Peaks

Hg19::chr19:7989858..7989889,-p2@CTXN1
Hg19::chr19:7990008..7990044,-p4@CTXN1
Hg19::chr19:7990260..7990308,+p@chr19:7990260..7990308
+
Hg19::chr19:7990991..7991059,-p1@CTXN1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
embryonic cell4.76e-15250
epithelial cell1.55e-14253
neurectodermal cell2.19e-1159
lining cell1.18e-0958
barrier cell1.18e-0958
ectodermal cell3.43e-0972
mesodermal cell1.80e-08121
neural cell6.60e-0825
squamous epithelial cell6.56e-0763
Uber Anatomy
Ontology termp-valuen
anatomical cluster1.67e-24373
central nervous system1.24e-2381
nervous system2.41e-2389
pre-chordal neural plate3.54e-1961
brain3.88e-1968
future brain3.88e-1968
cerebral hemisphere5.79e-1932
brain grey matter7.83e-1934
gray matter7.83e-1934
telencephalon9.07e-1934
neurectoderm1.09e-1886
regional part of telencephalon3.11e-1832
regional part of nervous system4.58e-1853
regional part of brain4.58e-1853
neural plate7.85e-1882
presumptive neural plate7.85e-1882
regional part of forebrain8.27e-1841
forebrain8.27e-1841
anterior neural tube8.27e-1841
future forebrain8.27e-1841
neural tube1.83e-1756
neural rod1.83e-1756
future spinal cord1.83e-1756
neural keel1.83e-1756
tube3.87e-16192
cell layer9.12e-16309
epithelium1.45e-15306
anatomical conduit7.95e-15240
cerebral cortex1.36e-1425
pallium1.36e-1425
ectoderm-derived structure1.52e-14171
ectoderm1.52e-14171
presumptive ectoderm1.52e-14171
ecto-epithelium6.51e-14104
organ system subdivision1.06e-13223
regional part of cerebral cortex2.83e-1322
structure with developmental contribution from neural crest7.32e-13132
multi-tissue structure1.92e-12342
neocortex5.11e-1220
embryo3.86e-09592
multi-cellular organism1.28e-08656
organ part3.44e-08218
developing anatomical structure1.49e-07581


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.15.41581
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.11.34758
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.11.28333
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.380957
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.11.22348
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.14.40535
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.92815
MA0145.10.195821
MA0146.11.75643
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.24.29465
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.13.88191
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.17.88428
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.29.35212
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90546.336201576962630.0006203100587215640.00512211908782586
CTCFL#140690314.80985576923080.0004996291767563340.00440939425310586
E2F4#187439.501045236463330.001850751034728270.0109283986722443
MAX#414934.839416631755340.01315737137836840.0466221995448671
NANOG#79923214.62238924050630.006698757715363760.0284916129926644
NRF1#4899412.21027944771094.49717228915276e-050.00079391510599531
PAX5#507935.002174148383370.01196533174786410.043494736779617
RAD21#588537.766275421592250.0033411193858720.0172684301252579
SETDB1#9869330.24001963350795.98509618524166e-050.000984684090249612
SMC3#9126311.28369963369960.001115802366868050.00765709201612016
ZBTB7A#5134147.35190930787590.000342223540015990.00346600895032292
ZNF143#7702310.12565741417090.001534861610688180.0097666125485081



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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