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{{Coexpression_clusters
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|coexpression_dpi_cluster_scores_median=0,0

Latest revision as of 12:12, 17 September 2013


Full id: C2749_lung_smooth_uterus_cervix_vagina_ovary_kidney



Phase1 CAGE Peaks

Hg19::chr3:64670534..64670545,+p5@ADAMTS9-AS2
Hg19::chr3:64670551..64670629,+p2@ADAMTS9-AS2
Hg19::chr3:64670630..64670642,+p3@ADAMTS9-AS2
Hg19::chr3:64670757..64670798,+p1@ADAMTS9-AS2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism1.33e-53114
neural tube1.54e-2856
neural rod1.54e-2856
future spinal cord1.54e-2856
neural keel1.54e-2856
regional part of nervous system2.02e-2653
regional part of brain2.02e-2653
neural plate1.67e-2582
presumptive neural plate1.67e-2582
neurectoderm1.14e-2386
regional part of forebrain8.36e-2341
forebrain8.36e-2341
anterior neural tube8.36e-2341
future forebrain8.36e-2341
structure with developmental contribution from neural crest1.29e-20132
brain1.27e-1968
future brain1.27e-1968
brain grey matter3.95e-1934
gray matter3.95e-1934
telencephalon8.44e-1934
pre-chordal neural plate1.11e-1861
central nervous system4.53e-1881
regional part of telencephalon9.46e-1832
cerebral hemisphere1.28e-1732
ecto-epithelium2.07e-17104
nervous system1.72e-1689
anatomical cluster8.55e-15373
regional part of cerebral cortex1.35e-1422
multi-tissue structure2.96e-14342
cerebral cortex1.23e-1325
pallium1.23e-1325
neocortex2.33e-1320
organ system subdivision4.08e-13223
ectoderm-derived structure6.56e-13171
ectoderm6.56e-13171
presumptive ectoderm6.56e-13171
multi-cellular organism4.35e-12656
anatomical conduit5.40e-12240
organ3.37e-11503
anatomical system1.08e-10624
anatomical group1.48e-10625
tube2.57e-09192
epithelium6.92e-09306
cell layer1.88e-08309
organ part3.78e-08218
neural nucleus5.02e-079
nucleus of brain5.02e-079
posterior neural tube5.30e-0715
chordal neural plate5.30e-0715
basal ganglion9.32e-079
nuclear complex of neuraxis9.32e-079
aggregate regional part of brain9.32e-079
collection of basal ganglia9.32e-079
cerebral subcortex9.32e-079


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.11.69588
MA0006.11.31813
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.12.36201
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.69331
MA0058.12.50688
MA0059.12.50216
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.13.35176
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.12.03364
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.21.79838
MA0047.20.856092
MA0112.20.187982
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.533581
MA0156.10.560797
MA0157.13.66667
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.122011
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOS#235348.99795530889440.0001525147711168630.00195130346449517
GATA2#2624412.7449317335543.78864877853583e-050.00072336871989306
MAX#414946.452555509007120.0005767613195645490.0048601238868809
REST#597849.650028716128020.0001152825614219170.00157344425409613
USF1#739146.361499277207960.0006105011399140830.00508656789401571



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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