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{{Coexpression_clusters
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|full_id=C2932_occipital_astrocytoma_gall_medial_postcentral_parietal_brain
|id=C2932
|ontology_enrichment_celltype=CL:0002321!1.19e-12!248;CL:0000220!2.53e-12!246;CL:0002319!8.33e-09!25;CL:0000359!8.97e-09!32;CL:0000222!3.05e-08!119;CL:0000055!1.05e-07!180;CL:0000192!1.23e-07!42;CL:0000514!1.23e-07!42;CL:0000393!1.23e-07!60;CL:0000211!1.23e-07!60
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0001017!4.52e-31!82;UBERON:0005743!7.61e-31!86;UBERON:0000073!1.71e-30!94;UBERON:0001016!1.71e-30!94;UBERON:0000955!4.50e-27!69;UBERON:0006238!4.50e-27!69;UBERON:0001049!9.03e-24!57;UBERON:0005068!9.03e-24!57;UBERON:0006241!9.03e-24!57;UBERON:0007135!9.03e-24!57;UBERON:0002616!1.78e-23!59;UBERON:0003075!4.68e-23!86;UBERON:0007284!4.68e-23!86;UBERON:0004111!7.60e-23!241;UBERON:0000033!2.08e-22!123;UBERON:0000025!6.64e-22!194;UBERON:0004121!1.04e-21!169;UBERON:0002346!1.20e-21!90;UBERON:0002780!5.80e-21!41;UBERON:0001890!5.80e-21!41;UBERON:0006240!5.80e-21!41;UBERON:0000924!6.16e-21!173;UBERON:0006601!6.16e-21!173;UBERON:0000153!1.09e-20!129;UBERON:0007811!1.09e-20!129;UBERON:0000483!1.58e-20!309;UBERON:0000119!1.62e-20!312;UBERON:0003080!1.01e-19!42;UBERON:0001893!1.04e-19!34;UBERON:0001869!1.41e-19!32;UBERON:0002020!2.06e-19!34;UBERON:0003528!2.06e-19!34;UBERON:0000477!2.43e-19!286;UBERON:0002791!4.92e-19!33;UBERON:0003056!1.47e-17!61;UBERON:0000956!5.41e-16!25;UBERON:0000203!5.41e-16!25;UBERON:0000475!6.66e-15!365;UBERON:0000467!1.38e-14!625;UBERON:0000480!1.92e-14!626;UBERON:0002619!3.27e-14!22;UBERON:0001950!3.36e-13!20;UBERON:0000468!5.00e-13!659;UBERON:0002049!9.80e-13!79;UBERON:0007798!9.80e-13!79;UBERON:0001637!9.94e-13!42;UBERON:0003509!9.94e-13!42;UBERON:0004572!9.94e-13!42;UBERON:0000922!2.06e-12!612;UBERON:0001981!2.79e-11!60;UBERON:0007500!2.79e-11!60;UBERON:0004537!2.79e-11!60;UBERON:0006965!2.79e-11!60;UBERON:0000923!2.89e-11!604;UBERON:0005291!2.89e-11!604;UBERON:0006598!2.89e-11!604;UBERON:0002532!2.89e-11!604;UBERON:0002050!3.30e-11!605;UBERON:0005423!3.30e-11!605;UBERON:0000055!3.30e-11!69;UBERON:0004573!9.83e-11!33;UBERON:0004571!9.83e-11!33;UBERON:0000481!1.75e-10!347;UBERON:0004872!5.85e-09!84;UBERON:0001009!4.64e-08!113;UBERON:0004535!8.07e-08!110;UBERON:0000947!1.93e-07!21;UBERON:0010191!1.93e-07!21
}}

Latest revision as of 12:15, 17 September 2013


Full id: C2932_occipital_astrocytoma_gall_medial_postcentral_parietal_brain



Phase1 CAGE Peaks

Hg19::chr8:94929594..94929608,+p21@PDP1
Hg19::chr8:94929969..94929980,+p8@PDP1
Hg19::chr8:94930034..94930089,+p2@PDP1
Hg19::chr8:94930100..94930120,+p5@PDP1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
neural cell9.64e-0925
embryonic cell1.65e-08250
Uber Anatomy
Ontology termp-valuen
central nervous system4.91e-3681
nervous system1.04e-3589
brain2.37e-3168
future brain2.37e-3168
neural tube1.74e-3056
neural rod1.74e-3056
future spinal cord1.74e-3056
neural keel1.74e-3056
regional part of nervous system1.11e-2953
regional part of brain1.11e-2953
regional part of forebrain6.34e-2641
forebrain6.34e-2641
anterior neural tube6.34e-2641
future forebrain6.34e-2641
neural plate6.68e-2582
presumptive neural plate6.68e-2582
telencephalon2.01e-2434
cerebral hemisphere3.19e-2432
brain grey matter3.74e-2434
gray matter3.74e-2434
neurectoderm1.16e-2386
regional part of telencephalon3.24e-2332
ectoderm-derived structure5.83e-23171
ectoderm5.83e-23171
presumptive ectoderm5.83e-23171
ecto-epithelium1.76e-22104
anatomical conduit3.05e-22240
anatomical cluster8.90e-22373
structure with developmental contribution from neural crest4.41e-21132
pre-chordal neural plate7.65e-2161
tube9.08e-21192
cerebral cortex1.10e-1925
pallium1.10e-1925
regional part of cerebral cortex2.38e-1722
cell layer6.28e-17309
epithelium6.85e-17306
neocortex4.75e-1620
organ system subdivision2.57e-14223
anatomical system1.20e-11624
anatomical group1.66e-11625
embryo1.67e-11592
multi-cellular organism2.56e-11656
multi-tissue structure7.62e-10342
developing anatomical structure7.92e-10581
embryonic structure1.13e-09564
germ layer1.25e-09560
germ layer / neural crest1.25e-09560
embryonic tissue1.25e-09560
presumptive structure1.25e-09560
germ layer / neural crest derived structure1.25e-09560
epiblast (generic)1.25e-09560
organ part3.60e-08218
adult organism3.53e-07114
vasculature5.82e-0778
vascular system5.82e-0778
Disease
Ontology termp-valuen
squamous cell carcinoma8.62e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.13.49532
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.12.45009
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.11.28887
MA0056.10
MA0057.11.28333
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.12.31526
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.113.7162
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.11.15856
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.70272
MA0146.12.31379
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.22.52211
MA0138.22.1393
MA0002.21.75253
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.23.12566
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.21162
MA0155.11.61785
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.12.80246
MA0163.12.49771
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.29.35212
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
TAF1#687243.343046285745290.008005664898701650.0323506920625073
TCF7L2#693438.077632422353010.002978381685834620.0158736071079241



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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