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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0.204012111330819,

Latest revision as of 12:29, 17 September 2013


Full id: C3613_optic_Hep2_corpus_lens_Mesenchymal_globus_Chondrocyte



Phase1 CAGE Peaks

Hg19::chr17:20059323..20059342,+p4@SPECC1
Hg19::chr17:20059346..20059355,+p5@SPECC1
Hg19::chr17:20059358..20059401,+p1@SPECC1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell2.51e-17253
endo-epithelial cell1.55e-0742
Uber Anatomy
Ontology termp-valuen
central nervous system6.94e-1981
nervous system8.35e-1789
organ system subdivision1.35e-15223
neural tube3.05e-1556
neural rod3.05e-1556
future spinal cord3.05e-1556
neural keel3.05e-1556
brain3.42e-1568
future brain3.42e-1568
regional part of nervous system7.55e-1453
regional part of brain7.55e-1453
organ part8.55e-13218
ecto-epithelium2.61e-12104
ectoderm-derived structure4.52e-12171
ectoderm4.52e-12171
presumptive ectoderm4.52e-12171
neural plate4.88e-1282
presumptive neural plate4.88e-1282
brain grey matter2.69e-1134
gray matter2.69e-1134
telencephalon3.32e-1134
regional part of forebrain7.15e-1141
forebrain7.15e-1141
anterior neural tube7.15e-1141
future forebrain7.15e-1141
pre-chordal neural plate2.46e-1061
regional part of telencephalon2.76e-1032
neurectoderm3.14e-1086
cerebral hemisphere4.04e-1032
larynx1.37e-079
cerebral cortex1.45e-0725
pallium1.45e-0725
multi-tissue structure3.92e-07342
regional part of cerebral cortex6.94e-0722
structure with developmental contribution from neural crest7.22e-07132
Disease
Ontology termp-valuen
carcinoma2.42e-12106
cell type cancer2.98e-09143
reproductive organ cancer2.65e-0729
disease of cellular proliferation2.78e-07239
cancer2.84e-07235


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.13.22681
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.15.4446
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.13.15032
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.13.60951
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.12.18164
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.14.82347
MA0146.14.51393
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.24.75888
MA0138.21.04628
MA0002.20.476938
MA0137.21.60005
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.16.1256
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.21.54885
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189811172084913
E2F1#186934.907389214879320.008460985347239390.0324838013704494
E2F6#187635.017155731697390.00791769806886330.0321644742546973
EGR1#195834.988179094810140.008056488137383440.0320184011788953
ELF1#199734.258097958807540.01295179875054610.0461631598426143
IRF1#365937.63716375356390.002244692747297240.012791698905166
JUND#372736.994663941871030.002921845042734990.01565457212426
MEF2A#4205318.74323090964410.0001518243905622470.00195011530266025
MYC#460935.22228187160940.007020843755740150.0294147104061997
NFKB1#479035.488063424193840.006049381815655430.0269317271599488
PAX5#507936.669565531177830.003370290999677260.0172755740719163
POU2F2#545239.106124057742520.001324165192682130.00881418027779025
SMARCB1#6598318.25271578115740.000164397760679890.0020290165123667
SP1#666735.69838137814090.005403962701712170.0246165857113498
TAF7#6879311.43306940492390.0006690181981945830.00542144565496928
TCF12#6938310.63446490218640.0008313523990202070.00628806584597852
ZEB1#6935316.88843201754390.0002075486917327580.00242571372156194
ZNF143#7702313.50087655222790.0004062804962997170.00388709497554471



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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