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Coexpression cluster:C4500: Difference between revisions

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{{Coexpression_clusters
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|full_id=C4500_small_frontal_insula_Hep2_non_amygdala_paracentral
|id=C4500
}}

Latest revision as of 14:14, 17 September 2013


Full id: C4500_small_frontal_insula_Hep2_non_amygdala_paracentral



Phase1 CAGE Peaks

Hg19::chr5:41870475..41870494,-p2@OXCT1
Hg19::chr5:41870495..41870512,-p4@OXCT1
Hg19::chr5:41870518..41870535,-p1@OXCT1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
lymphoid lineage restricted progenitor cell6.77e-1552
lymphocyte2.02e-1453
common lymphoid progenitor2.02e-1453
nucleate cell9.92e-1455
T cell1.40e-0925
pro-T cell1.40e-0925
mature alpha-beta T cell4.28e-0718
alpha-beta T cell4.28e-0718
immature T cell4.28e-0718
mature T cell4.28e-0718
immature alpha-beta T cell4.28e-0718
Uber Anatomy
Ontology termp-valuen
cerebral hemisphere9.36e-1432
telencephalon1.04e-1234
regional part of forebrain1.46e-1241
forebrain1.46e-1241
anterior neural tube1.46e-1241
future forebrain1.46e-1241
brain grey matter1.70e-1234
gray matter1.70e-1234
regional part of nervous system1.87e-1253
regional part of brain1.87e-1253
brain2.11e-1268
future brain2.11e-1268
neural tube2.28e-1256
neural rod2.28e-1256
future spinal cord2.28e-1256
neural keel2.28e-1256
regional part of telencephalon2.51e-1232
central nervous system2.81e-1281
cerebral cortex1.29e-1125
pallium1.29e-1125
nervous system1.36e-1189
regional part of cerebral cortex1.86e-1122
neocortex1.22e-1020
neural plate8.09e-0982
presumptive neural plate8.09e-0982
ecto-epithelium9.34e-09104
structure with developmental contribution from neural crest9.35e-09132
neurectoderm7.08e-0886
pre-chordal neural plate8.19e-0861
ectoderm-derived structure1.02e-07171
ectoderm1.02e-07171
presumptive ectoderm1.02e-07171
larynx1.33e-079
upper respiratory tract9.21e-0719


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.06172
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.12.01615
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.11.55947
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.96087
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.455568
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.22.26143
MA0099.20.902716
MA0079.20.0373086
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672320.18423064322380.0001215704860271640.00164422429295402
CCNT2#90536.336201576962630.003930750035764890.0190879064018807
E2F1#186934.907389214879320.008460985347239390.0327159144272616
E2F6#187635.017155731697390.00791769806886330.0323912596895301
HMGN3#932438.178547723350590.001827766942164210.0109067621799045
MXI1#460139.96157162875930.001011470541259020.00722452276422863
MYC#460935.22228187160940.007020843755740150.0295689128561072
NFKB1#479035.488063424193840.006049381815655430.0270597647526657
NRF1#4899312.21027944771090.0005492172401020010.00472913672512267
PAX5#507936.669565531177830.003370290999677260.0173539329347381
POU2F2#545239.106124057742520.001324165192682130.00885028084977147
RFX5#5993312.04791082719510.0005717246050312580.0048616142342338
SMARCB1#6598318.25271578115740.000164397760679890.00203744366057281
SPI1#668838.204323508522730.001810593189410520.0109348604700656
STAT1#6772320.70658749719920.0001125992441046670.00155285256239896
TCF12#6938310.63446490218640.0008313523990202070.00631367169875446
TCF7L2#6934310.77017656313730.0008003181298398380.00616540718170265
YY1#752834.911170749853860.008441455341808260.03308876874505
ZEB1#6935316.88843201754390.0002075486917327580.00243552559728961
ZNF263#1012738.221841637010680.001799043925565870.0109928825498581



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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