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{{CL
{{CL
|id=CL:0000235
|alt_id=
|name=macrophage
|namespace=cell;;efo
|def="A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437]
|xref=BTO:0000801;;FMA:63261;;FMA:83585
|is_a=CL:0000234;;CL:0000766
|synonym="histiocyte" EXACT []
|comment=Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
|comment=Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.
|alt_id=
|disjoint_from=
|union_of=
|created_by=
|created_by=
|obo_creation_date=
|def="A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437]
|subset=
|derives_from=
|derives_from=
|develops_from=
|develops_from=CL:0000576
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0000235
|is_a=CL:0000234 ;;CL:0000766
|is_obsolete=
|located_in=
|located_in=
|name=macrophage
|namespace=FANTOM
|obo_creation_date=
|part_of=
|part_of=
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl.owl;;IAO:0000412 http://purl.obolibrary.org/obo/efo.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym="histiocyte" EXACT []
|union_of=
|xref=BTO:0000801;;FMA:63261;;FMA:83585
}}
}}

Latest revision as of 16:32, 12 September 2014

Name:macrophage
Namespace:FANTOM
Definition:"A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437]
Xrefs:
links:

BTO:0000801
FMA:63261

FMA:83585
Synonyms: "histiocyte" EXACT []
Comments:Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000234(phagocyte),CL:0000766(myeloid leukocyte)
develops_from:CL:0000576(monocyte)



Children


is a:CL:0000864 (tissue-resident macrophage)
derives from:FF:0000086 (human macrophage sample),FF:0200001 (macrophage, TB infection sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000235 (macrophage), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
2.37e-195FFCP PHASE1:Hg19::chr20:44639118..44639130,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44639118..44639130, +
2.37e-195FFCP PHASE1:Hg19::chr20:44638551..44638562,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44638551..44638562, +
2.37e-195FFCP PHASE2:Hg19::chr20:44639118..44639130,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44639118..44639130, +
2.37e-195FFCP PHASE2:Hg19::chr20:44638551..44638562,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44638551..44638562, +
2.37e-195FFCP PHASE1:Hg19::chr20:44640347..44640359,+#_1b6c67710e2aeff5edb084b7ff71cd57p11@MMP9
2.37e-195FFCP PHASE2:Hg19::chr20:44640347..44640359,+#_1b6c67710e2aeff5edb084b7ff71cd57p11@MMP9
2.37e-195FFCP PHASE1:Hg19::chr20:44641953..44641968,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44641953..44641968, +
2.37e-195FFCP PHASE2:Hg19::chr20:44641953..44641968,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44641953..44641968, +
5.73e-168FFCP PHASE1:Hg19::chr20:44638694..44638710,+#_ef1822b7512b17d46108cdf297257c23p@chr20:44638694..44638710, +
5.73e-168FFCP PHASE2:Hg19::chr20:44638694..44638710,+#_ef1822b7512b17d46108cdf297257c23p@chr20:44638694..44638710, +
5.73e-168FFCP PHASE1:Hg19::chr20:44638717..44638738,-#_ef1822b7512b17d46108cdf297257c23p@chr20:44638717..44638738, -
5.73e-168FFCP PHASE2:Hg19::chr20:44638717..44638738,-#_ef1822b7512b17d46108cdf297257c23p@chr20:44638717..44638738, -
5.73e-168FFCP PHASE1:Hg19::chr20:44638633..44638646,+#_ef1822b7512b17d46108cdf297257c23p@chr20:44638633..44638646, +
5.73e-168FFCP PHASE2:Hg19::chr20:44638633..44638646,+#_ef1822b7512b17d46108cdf297257c23p@chr20:44638633..44638646, +
7.64e-168FFCP PHASE1:Hg19::chr20:44638515..44638530,+#_89572743b093fd89ba9bfb7d604d7385p@chr20:44638515..44638530, +
7.64e-168FFCP PHASE2:Hg19::chr20:44638515..44638530,+#_89572743b093fd89ba9bfb7d604d7385p@chr20:44638515..44638530, +
1.02e-167FFCP PHASE1:Hg19::chr20:44642333..44642369,+#_bf802cdba157b0fb27b33b4f7e28cb5cp@chr20:44642333..44642369, +
1.02e-167FFCP PHASE2:Hg19::chr20:44642333..44642369,+#_bf802cdba157b0fb27b33b4f7e28cb5cp@chr20:44642333..44642369, +
1.02e-167FFCP PHASE1:Hg19::chr20:44645128..44645150,+#_bf802cdba157b0fb27b33b4f7e28cb5cp@chr20:44645128..44645150, +
1.02e-167FFCP PHASE2:Hg19::chr20:44645128..44645150,+#_bf802cdba157b0fb27b33b4f7e28cb5cp@chr20:44645128..44645150, +
1.02e-167FFCP PHASE1:Hg19::chr20:44640312..44640322,+#_bf802cdba157b0fb27b33b4f7e28cb5cp10@MMP9
1.02e-167FFCP PHASE2:Hg19::chr20:44640312..44640322,+#_bf802cdba157b0fb27b33b4f7e28cb5cp10@MMP9
5.41e-163FFCP PHASE1:Hg19::chr20:44640304..44640310,+#_ad3ea0be2280eecaa4dfcd97ce8f79afp13@MMP9
5.41e-163FFCP PHASE2:Hg19::chr20:44640304..44640310,+#_ad3ea0be2280eecaa4dfcd97ce8f79afp13@MMP9
5.41e-163FFCP PHASE1:Hg19::chr20:44640866..44640875,-#_ad3ea0be2280eecaa4dfcd97ce8f79afp@chr20:44640866..44640875, -
5.41e-163FFCP PHASE2:Hg19::chr20:44640866..44640875,-#_ad3ea0be2280eecaa4dfcd97ce8f79afp@chr20:44640866..44640875, -
5.41e-163FFCP PHASE1:Hg19::chr20:44638625..44638633,-#_ad3ea0be2280eecaa4dfcd97ce8f79afp@chr20:44638625..44638633, -
5.41e-163FFCP PHASE2:Hg19::chr20:44638625..44638633,-#_ad3ea0be2280eecaa4dfcd97ce8f79afp@chr20:44638625..44638633, -
1.99e-147FFCP PHASE2:Hg19::chr20:44640269..44640283,+#_38f35c6691261d45b7860f0835be0f85p7@MMP9
1.99e-147FFCP PHASE1:Hg19::chr20:44638500..44638512,+#_38f35c6691261d45b7860f0835be0f85p@chr20:44638500..44638512, +
1.99e-147FFCP PHASE2:Hg19::chr20:44638500..44638512,+#_38f35c6691261d45b7860f0835be0f85p@chr20:44638500..44638512, +
1.99e-147FFCP PHASE1:Hg19::chr20:44639634..44639645,+#_38f35c6691261d45b7860f0835be0f85p@chr20:44639634..44639645, +
1.99e-147FFCP PHASE2:Hg19::chr20:44639634..44639645,+#_38f35c6691261d45b7860f0835be0f85p@chr20:44639634..44639645, +
1.99e-147FFCP PHASE1:Hg19::chr20:44640269..44640283,+#_38f35c6691261d45b7860f0835be0f85p7@MMP9
2.56e-147FFCP PHASE1:Hg19::chr20:44638566..44638579,+#_9962213947827c29fc3c494f47f527a7p@chr20:44638566..44638579, +
2.56e-147FFCP PHASE2:Hg19::chr20:44638566..44638579,+#_9962213947827c29fc3c494f47f527a7p@chr20:44638566..44638579, +
2.56e-147FFCP PHASE1:Hg19::chr20:44638613..44638632,+#_9962213947827c29fc3c494f47f527a7p@chr20:44638613..44638632, +
2.56e-147FFCP PHASE2:Hg19::chr20:44638613..44638632,+#_9962213947827c29fc3c494f47f527a7p@chr20:44638613..44638632, +
5.45e-147FFCP PHASE1:Hg19::chr20:44639771..44639782,+#_5928f006d1ec65317ca25577abb2d92fp@chr20:44639771..44639782, +
5.45e-147FFCP PHASE2:Hg19::chr20:44639771..44639782,+#_5928f006d1ec65317ca25577abb2d92fp@chr20:44639771..44639782, +
7.01e-147FFCP PHASE1:Hg19::chr20:44641138..44641146,+#_61ea002cba5ccb1f22f03072ebc78f82p@chr20:44641138..44641146, +
7.01e-147FFCP PHASE2:Hg19::chr20:44641138..44641146,+#_61ea002cba5ccb1f22f03072ebc78f82p@chr20:44641138..44641146, +
3.49e-136FFCP PHASE1:Hg19::chr20:44639929..44639935,+#_2de983a9177354a727868f6ad017199ep@chr20:44639929..44639935, +
3.49e-136FFCP PHASE2:Hg19::chr20:44639929..44639935,+#_2de983a9177354a727868f6ad017199ep@chr20:44639929..44639935, +
4.61e-136FFCP PHASE2:Hg19::chr9:86983573..86983587,-#_ab0c398acde8e81034657cf57d72eabdp6@SLC28A3
4.61e-136FFCP PHASE1:Hg19::chr9:86983573..86983587,-#_ab0c398acde8e81034657cf57d72eabdp6@SLC28A3
1.89e-131FFCP PHASE1:Hg19::chr20:44639910..44639947,-#_a9d2fa14160aaba1a9dec28f7c706882p@chr20:44639910..44639947, -
1.89e-131FFCP PHASE2:Hg19::chr20:44639910..44639947,-#_a9d2fa14160aaba1a9dec28f7c706882p@chr20:44639910..44639947, -
1.89e-131FFCP PHASE1:Hg19::chr20:44639149..44639161,+#_a9d2fa14160aaba1a9dec28f7c706882p@chr20:44639149..44639161, +
1.89e-131FFCP PHASE2:Hg19::chr20:44639149..44639161,+#_a9d2fa14160aaba1a9dec28f7c706882p@chr20:44639149..44639161, +
5.81e-131FFCP PHASE1:Hg19::chr20:44641166..44641180,+#_e61b1dab2458e8334efb89215601b20ep@chr20:44641166..44641180, +
5.81e-131FFCP PHASE2:Hg19::chr20:44641166..44641180,+#_e61b1dab2458e8334efb89215601b20ep@chr20:44641166..44641180, +
1.07e-130FFCP PHASE1:Hg19::chr6:164082461..164082467,-#_ccbd6d4b303530e41efaf16c5030b331p@chr6:164082461..164082467, -
1.07e-130FFCP PHASE1:Hg19::chr5:147789958..147789969,+#_ccbd6d4b303530e41efaf16c5030b331p5@FBXO38
1.07e-130FFCP PHASE2:Hg19::chr5:147789958..147789969,+#_ccbd6d4b303530e41efaf16c5030b331p5@FBXO38
1.07e-130FFCP PHASE2:Hg19::chr6:164082461..164082467,-#_ccbd6d4b303530e41efaf16c5030b331p@chr6:164082461..164082467, -
1.15e-118FFCP PHASE1:Hg19::chr20:44638657..44638691,+#_c68de898b87ba5530c1d3b49f5c47e53p@chr20:44638657..44638691, +
1.15e-118FFCP PHASE2:Hg19::chr20:44638657..44638691,+#_c68de898b87ba5530c1d3b49f5c47e53p@chr20:44638657..44638691, +
1.15e-118FFCP PHASE1:Hg19::chr20:44639584..44639604,+#_c68de898b87ba5530c1d3b49f5c47e53p@chr20:44639584..44639604, +
1.15e-118FFCP PHASE2:Hg19::chr20:44639584..44639604,+#_c68de898b87ba5530c1d3b49f5c47e53p@chr20:44639584..44639604, +
1.73e-118FFCP PHASE1:Hg19::chr20:44641061..44641077,+#_4c88df6ec7625d65a009554c1b7193b2p@chr20:44641061..44641077, +
1.73e-118FFCP PHASE2:Hg19::chr20:44641061..44641077,+#_4c88df6ec7625d65a009554c1b7193b2p@chr20:44641061..44641077, +
4.35e-117FFCP PHASE1:Hg19::chr14:61452664..61452679,+#_deb102209832f851df239d27d62cb1fdp@chr14:61452664..61452679, +
4.35e-117FFCP PHASE2:Hg19::chrX:46639989..46640013,-#_deb102209832f851df239d27d62cb1fdp@chrX:46639989..46640013, -
4.35e-117FFCP PHASE2:Hg19::chr14:61452664..61452679,+#_deb102209832f851df239d27d62cb1fdp@chr14:61452664..61452679, +
4.35e-117FFCP PHASE1:Hg19::chrX:46639989..46640013,-#_deb102209832f851df239d27d62cb1fdp@chrX:46639989..46640013, -
4.98e-117FFCP PHASE1:Hg19::chr20:44639896..44639903,+#_978d2f722ce0dfa64f3eb042ff33822ap@chr20:44639896..44639903, +
4.98e-117FFCP PHASE2:Hg19::chr20:44639896..44639903,+#_978d2f722ce0dfa64f3eb042ff33822ap@chr20:44639896..44639903, +
8.05e-117FFCP PHASE2:Hg19::chr6:4347006..4347027,-#_d5fafda2dbb434ecc724e134e89ebbf8p@chr6:4347006..4347027, -
8.05e-117FFCP PHASE1:Hg19::chr6:4347006..4347027,-#_d5fafda2dbb434ecc724e134e89ebbf8p@chr6:4347006..4347027, -
5.81e-108FFCP PHASE1:Hg19::chr20:44640829..44640856,+#_8165ebdcec529dacc0596359cb178de4p4@MMP9
5.81e-108FFCP PHASE2:Hg19::chr20:44640829..44640856,+#_8165ebdcec529dacc0596359cb178de4p4@MMP9
2.53e-107FFCP PHASE1:Hg19::chr8:24256905..24256914,+#_45fecd9dfd55e0c0ed2464e5389beeb2p@chr8:24256905..24256914, +
2.53e-107FFCP PHASE2:Hg19::chr8:24256905..24256914,+#_45fecd9dfd55e0c0ed2464e5389beeb2p@chr8:24256905..24256914, +
3.04e-107FFCP PHASE2:Hg19::chr7:137308..137321,+#_69c9cb29dd6614e8dc44ac923979ba13p@chr7:137308..137321, +
3.04e-107FFCP PHASE1:Hg19::chr7:137308..137321,+#_69c9cb29dd6614e8dc44ac923979ba13p@chr7:137308..137321, +
6.32e-107FFCP PHASE1:Hg19::chr19:45418067..45418076,+#_947633915711acf39a6e735aa87087e6p7@APOC1
6.32e-107FFCP PHASE2:Hg19::chr19:45418067..45418076,+#_947633915711acf39a6e735aa87087e6p7@APOC1
7.59e-107FFCP PHASE2:Hg19::chr6:46700055..46700067,-#_19c52bcdc4955a5dd9520cb5d180fc10p@chr6:46700055..46700067, -
7.59e-107FFCP PHASE1:Hg19::chr6:46700055..46700067,-#_19c52bcdc4955a5dd9520cb5d180fc10p@chr6:46700055..46700067, -
6.76e-105FFCP PHASE2:Hg19::chr17:62315972..62315978,-#_021d3f5a9c8a464bd65df08ab4fbabe1p@chr17:62315972..62315978, -
6.76e-105FFCP PHASE1:Hg19::chr17:62315972..62315978,-#_021d3f5a9c8a464bd65df08ab4fbabe1p@chr17:62315972..62315978, -
5.07e-102FFCP PHASE2:Hg19::chr17:29281302..29281321,+#_aeecea40033812b82c371ed766522dbbp6@ADAP2
5.07e-102FFCP PHASE1:Hg19::chr17:29281302..29281321,+#_aeecea40033812b82c371ed766522dbbp6@ADAP2
1.44e-101FFCP PHASE2:Hg19::chr5:150873510..150873548,+#_3a5ea8d82598857fa6ec684560490e89p@chr5:150873510..150873548, +
1.44e-101FFCP PHASE1:Hg19::chr5:150873510..150873548,+#_3a5ea8d82598857fa6ec684560490e89p@chr5:150873510..150873548, +
1.76e-99FFCP PHASE1:Hg19::chr20:44641085..44641097,+#_a516629f939638c41f9c12760f4ca6d9p@chr20:44641085..44641097, +
1.76e-99FFCP PHASE2:Hg19::chr20:44641085..44641097,+#_a516629f939638c41f9c12760f4ca6d9p@chr20:44641085..44641097, +
1.76e-99FFCP PHASE1:Hg19::chr20:44639906..44639917,+#_a516629f939638c41f9c12760f4ca6d9p@chr20:44639906..44639917, +
1.76e-99FFCP PHASE2:Hg19::chr20:44639906..44639917,+#_a516629f939638c41f9c12760f4ca6d9p@chr20:44639906..44639917, +
1.76e-99FFCP PHASE1:Hg19::chr20:44639141..44639152,-#_a516629f939638c41f9c12760f4ca6d9p@chr20:44639141..44639152, -
1.76e-99FFCP PHASE2:Hg19::chr20:44639141..44639152,-#_a516629f939638c41f9c12760f4ca6d9p@chr20:44639141..44639152, -
1.83e-98FFCP PHASE2:Hg19::chr6:164082477..164082487,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr6:164082477..164082487, -
1.83e-98FFCP PHASE1:Hg19::chr6:4346987..4346998,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr6:4346987..4346998, -
1.83e-98FFCP PHASE1:Hg19::chr6:164082477..164082487,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr6:164082477..164082487, -
1.83e-98FFCP PHASE1:Hg19::chr20:44639616..44639619,+#_3bc0af37f50f6166a31b0f14829ba06dp@chr20:44639616..44639619, +
1.83e-98FFCP PHASE2:Hg19::chr20:44639616..44639619,+#_3bc0af37f50f6166a31b0f14829ba06dp@chr20:44639616..44639619, +
1.83e-98FFCP PHASE1:Hg19::chr20:44639171..44639178,+#_3bc0af37f50f6166a31b0f14829ba06dp@chr20:44639171..44639178, +
1.83e-98FFCP PHASE2:Hg19::chr20:44639171..44639178,+#_3bc0af37f50f6166a31b0f14829ba06dp@chr20:44639171..44639178, +
1.83e-98FFCP PHASE1:Hg19::chr1:156510852..156510859,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr1:156510852..156510859, -

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