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Coexpression cluster:C2866: Difference between revisions

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{{Coexpression_clusters
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|full_id=C2866_Fibroblast_Preadipocyte_rhabdomyosarcoma_Myoblast_mesenchymal_Smooth_liposarcoma
|id=C2866
|ontology_enrichment_celltype=CL:0000055!1.78e-26!180;CL:0000057!2.16e-18!75;CL:0002620!1.53e-11!23
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0001017!2.56e-23!82;UBERON:0000955!6.05e-22!69;UBERON:0006238!6.05e-22!69;UBERON:0005743!1.00e-21!86;UBERON:0001049!3.15e-21!57;UBERON:0005068!3.15e-21!57;UBERON:0006241!3.15e-21!57;UBERON:0007135!3.15e-21!57;UBERON:0000073!3.44e-21!94;UBERON:0001016!3.44e-21!94;UBERON:0002616!7.95e-20!59;UBERON:0000475!7.21e-19!365;UBERON:0000033!8.39e-18!123;UBERON:0003075!1.51e-16!86;UBERON:0007284!1.51e-16!86;UBERON:0004121!3.36e-16!169;UBERON:0000153!1.40e-15!129;UBERON:0007811!1.40e-15!129;UBERON:0000924!5.01e-15!173;UBERON:0006601!5.01e-15!173;UBERON:0002780!5.42e-15!41;UBERON:0001890!5.42e-15!41;UBERON:0006240!5.42e-15!41;UBERON:0002346!9.24e-15!90;UBERON:0003080!1.71e-14!42;UBERON:0002020!3.65e-13!34;UBERON:0003528!3.65e-13!34;UBERON:0001893!1.15e-12!34;UBERON:0002791!2.59e-12!33;UBERON:0001869!4.19e-12!32;UBERON:0003056!4.46e-10!61;UBERON:0000956!1.82e-09!25;UBERON:0000203!1.82e-09!25;UBERON:0002619!4.71e-09!22;UBERON:0000481!1.21e-08!347;UBERON:0001950!1.81e-08!20;UBERON:0000914!1.96e-08!83;UBERON:0002329!1.96e-08!83;UBERON:0003077!1.96e-08!83;UBERON:0003059!1.96e-08!83;UBERON:0007282!1.96e-08!83;UBERON:0009618!1.96e-08!83;UBERON:0007285!1.96e-08!83;UBERON:0003076!4.04e-08!15;UBERON:0003057!4.04e-08!15;UBERON:0000477!4.80e-08!286;UBERON:0002097!9.65e-08!40;UBERON:0000025!1.26e-07!194;UBERON:0000483!1.96e-07!309;UBERON:0002199!2.72e-07!45;UBERON:0002416!2.72e-07!45;UBERON:0004732!3.85e-07!13;UBERON:0000119!7.21e-07!312;UBERON:0004733!9.02e-07!12;UBERON:0002028!9.02e-07!12;UBERON:0007277!9.02e-07!12;UBERON:0004111!9.80e-07!241
}}

Latest revision as of 12:14, 17 September 2013


Full id: C2866_Fibroblast_Preadipocyte_rhabdomyosarcoma_Myoblast_mesenchymal_Smooth_liposarcoma



Phase1 CAGE Peaks

Hg19::chr6:56819398..56819427,-p13@DST
Hg19::chr6:56819429..56819490,-p10@DST
Hg19::chr6:56819494..56819509,-p28@DST
Hg19::chr6:56819522..56819652,-p3@DST


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
fibroblast2.27e-1776
skin fibroblast2.86e-1123
non-terminally differentiated cell2.60e-08106
Uber Anatomy
Ontology termp-valuen
central nervous system4.09e-2481
brain4.94e-2368
future brain4.94e-2368
nervous system5.94e-2389
neural tube1.13e-2256
neural rod1.13e-2256
future spinal cord1.13e-2256
neural keel1.13e-2256
regional part of nervous system2.88e-2153
regional part of brain2.88e-2153
structure with developmental contribution from neural crest4.16e-20132
neural plate2.85e-1782
presumptive neural plate2.85e-1782
regional part of forebrain6.47e-1641
forebrain6.47e-1641
anterior neural tube6.47e-1641
future forebrain6.47e-1641
ectoderm-derived structure9.46e-16171
ectoderm9.46e-16171
presumptive ectoderm9.46e-16171
neurectoderm2.41e-1586
brain grey matter8.73e-1434
gray matter8.73e-1434
ecto-epithelium9.15e-14104
telencephalon3.06e-1334
regional part of telencephalon1.21e-1232
cerebral hemisphere1.35e-1232
pre-chordal neural plate5.05e-1161
cerebral cortex7.49e-1025
pallium7.49e-1025
organ system subdivision1.94e-09223
regional part of cerebral cortex2.10e-0922
multi-tissue structure5.04e-09342
neocortex1.23e-0820
skin of body4.79e-0841
posterior neural tube4.82e-0815
chordal neural plate4.82e-0815
integument1.38e-0746
integumental system1.38e-0746
segmental subdivision of nervous system4.46e-0713


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.14.74396
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.244769
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.13.07281
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.481
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.21.13403
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.199162
MA0150.13.7809
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.12.80246
MA0163.13.14178
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.21.85039
MA0079.28.14977
MA0102.21.75932
MA0258.10.418966
MA0259.11.1888
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90546.336201576962630.0006203100587215640.00513511114638724
E2F1#186944.907389214879320.001724022357361790.0106781621978714
E2F6#187645.017155731697390.00157802193473060.0099907270151145
EBF1#187948.9064668465690.00015887907472010.00199990016689075
EGR1#195844.988179094810140.001615011500076050.0101633035705256
HEY1#2346244.040111043105710.00375304636917980.018657864135128
MAFK#7975427.10073313782991.85228494563408e-066.85752525477058e-05
NFE2#4778477.2042606516292.80776035215453e-081.91910787577661e-06
PAX5#507946.669565531177830.0005052774169483260.00444834090438053
SIN3A#2594245.408884726815140.001168172384885160.0079802953757863
TAF1#687243.343046285745290.008005664898701650.0323269268618737
YY1#752844.911170749853860.00171871838055440.0107062644009735
ZBTB7A#5134135.513931980906920.009038352821081090.0342584209291169



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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