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{{Coexpression_clusters
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|full_id=C3219_smooth_granulocyte_liposarcoma_bladder_colon_hippocampus_endometrial
|id=C3219
|ontology_enrichment_celltype=
|ontology_enrichment_disease=DOID:0050687!2.13e-07!143
|ontology_enrichment_uberon=UBERON:0000033!1.03e-22!123;UBERON:0000955!2.86e-22!69;UBERON:0006238!2.86e-22!69;UBERON:0004121!2.12e-21!169;UBERON:0000924!6.21e-21!173;UBERON:0006601!6.21e-21!173;UBERON:0000153!8.97e-21!129;UBERON:0007811!8.97e-21!129;UBERON:0005743!2.77e-20!86;UBERON:0000073!1.75e-19!94;UBERON:0001016!1.75e-19!94;UBERON:0001017!2.04e-19!82;UBERON:0002616!2.14e-19!59;UBERON:0001049!3.26e-19!57;UBERON:0005068!3.26e-19!57;UBERON:0006241!3.26e-19!57;UBERON:0007135!3.26e-19!57;UBERON:0003075!8.76e-19!86;UBERON:0007284!8.76e-19!86;UBERON:0002346!5.79e-18!90;UBERON:0000475!4.76e-17!365;UBERON:0002780!1.58e-15!41;UBERON:0001890!1.58e-15!41;UBERON:0006240!1.58e-15!41;UBERON:0003080!1.60e-15!42;UBERON:0001869!3.90e-15!32;UBERON:0003056!5.89e-15!61;UBERON:0001893!9.32e-15!34;UBERON:0002020!1.14e-14!34;UBERON:0003528!1.14e-14!34;UBERON:0000956!2.78e-14!25;UBERON:0000203!2.78e-14!25;UBERON:0002791!3.83e-14!33;UBERON:0002619!2.37e-13!22;UBERON:0001950!4.22e-12!20;UBERON:0007023!1.45e-11!115;UBERON:0000481!1.16e-08!347;UBERON:0000119!1.48e-07!312;UBERON:0000483!5.25e-07!309;UBERON:0000062!9.10e-07!511
}}

Latest revision as of 12:21, 17 September 2013


Full id: C3219_smooth_granulocyte_liposarcoma_bladder_colon_hippocampus_endometrial



Phase1 CAGE Peaks

Hg19::chr12:104234966..104234984,-p3@NT5DC3
Hg19::chr12:104234989..104235022,-p1@NT5DC3
Hg19::chr12:104235025..104235067,-p2@NT5DC3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
brain5.10e-2168
future brain5.10e-2168
ecto-epithelium1.65e-19104
neural tube1.21e-1856
neural rod1.21e-1856
future spinal cord1.21e-1856
neural keel1.21e-1856
regional part of nervous system2.49e-1853
regional part of brain2.49e-1853
ectoderm-derived structure3.77e-18171
ectoderm3.77e-18171
presumptive ectoderm3.77e-18171
central nervous system9.80e-1881
neural plate7.71e-1782
presumptive neural plate7.71e-1782
nervous system8.89e-1789
neurectoderm4.95e-1686
regional part of forebrain4.05e-1541
forebrain4.05e-1541
anterior neural tube4.05e-1541
future forebrain4.05e-1541
cerebral hemisphere1.09e-1432
telencephalon1.59e-1434
organ system subdivision1.83e-14223
brain grey matter2.27e-1434
gray matter2.27e-1434
pre-chordal neural plate3.05e-1461
cerebral cortex7.70e-1425
pallium7.70e-1425
regional part of telencephalon1.01e-1332
regional part of cerebral cortex8.67e-1322
neocortex1.52e-1120
adult organism9.24e-11114
structure with developmental contribution from neural crest1.54e-08132
multi-tissue structure2.24e-07342


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.13.20493
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.15.56064
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.11.62115
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.13.15032
MA0056.10
MA0057.11.59304
MA0058.14.13609
MA0059.12.854
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.114.8936
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.13.82193
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.13.00132
MA0147.14.68342
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.214.5515
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.24.26635
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.111.239
MA0163.13.19905
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.211.5899
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCLAF1#9774321.65264761012189.8473954032885e-050.00138886175357738
CTCF#1066435.360256373075030.0064925092527670.0278525846724064
E2F1#186934.907389214879320.008460985347239390.0323897386071525
E2F6#187635.017155731697390.00791769806886330.0320721587330417
EBF1#187938.9064668465690.00141523283560980.00912717686292777
EGR1#195834.988179094810140.008056488137383440.0319309158885883
ETS1#211339.728760922202340.001085840092584840.00760386572545714
GATA3#2625327.2365163572064.94721007899563e-050.000849525934627137
IRF1#365937.63716375356390.002244692747297240.0127694027907281
MAX#414936.452555509007120.003721913834265510.0185889225257929
MXI1#460139.96157162875930.001011470541259020.00718618856180619
MYC#460935.22228187160940.007020843755740150.0293382107392368
NFKB1#479035.488063424193840.006049381815655430.0268710185201275
PAX5#507936.669565531177830.003370290999677260.0172417252860786
SIN3A#2594235.408884726815140.006318961977991520.0275632155544191
SMC3#9126315.04493284493280.0002935825420371870.00308217401566362
SP1#666735.69838137814090.005403962701712170.0245598111664107
TAF7#6879311.43306940492390.0006690181981945830.00540927394915569
USF1#739136.361499277207960.00388404057290560.0189642502755347
USF2#7392312.99219738506960.0004558979393427810.0042057702399983
ZBTB7A#5134137.35190930787590.002516255860282270.0139702964112498



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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