Coexpression cluster:C49: Difference between revisions
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Latest revision as of 10:17, 17 September 2013
Full id: C49_H9_iPS_testicular_HES3GFP_teratocarcinoma_hepatoblastoma_choriocarcinoma
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0003677 | DNA binding | 3.95036411579275e-15 |
GO:0005634 | nucleus | 1.20737198218058e-10 |
GO:0019222 | regulation of metabolic process | 1.2954821097401e-10 |
GO:0031323 | regulation of cellular metabolic process | 1.2954821097401e-10 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 1.2954821097401e-10 |
GO:0050794 | regulation of cellular process | 1.75651419149499e-10 |
GO:0006355 | regulation of transcription, DNA-dependent | 2.65857670272778e-10 |
GO:0010468 | regulation of gene expression | 3.30540380273447e-10 |
GO:0050789 | regulation of biological process | 4.50925840855671e-10 |
GO:0045449 | regulation of transcription | 4.50925840855671e-10 |
GO:0006351 | transcription, DNA-dependent | 4.50925840855671e-10 |
GO:0032774 | RNA biosynthetic process | 4.50925840855671e-10 |
GO:0006350 | transcription | 1.85301713394524e-09 |
GO:0043231 | intracellular membrane-bound organelle | 2.16633446218497e-09 |
GO:0043227 | membrane-bound organelle | 2.16633446218497e-09 |
GO:0065007 | biological regulation | 2.44035625068062e-09 |
GO:0016070 | RNA metabolic process | 4.33394817796637e-08 |
GO:0043283 | biopolymer metabolic process | 8.20472778744412e-08 |
GO:0007275 | multicellular organismal development | 4.28603624078332e-07 |
GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 4.72973755730249e-07 |
GO:0043229 | intracellular organelle | 5.62229326061631e-07 |
GO:0043226 | organelle | 5.62229326061631e-07 |
GO:0010467 | gene expression | 1.26337489093366e-06 |
GO:0003676 | nucleic acid binding | 1.53778188763554e-06 |
GO:0044424 | intracellular part | 1.53778188763554e-06 |
GO:0043565 | sequence-specific DNA binding | 1.30599182065928e-05 |
GO:0003700 | transcription factor activity | 2.29393153517212e-05 |
GO:0005622 | intracellular | 4.34543701848668e-05 |
GO:0008270 | zinc ion binding | 6.91704608320932e-05 |
GO:0043170 | macromolecule metabolic process | 0.00026424115832834 |
GO:0032502 | developmental process | 0.000398075066182975 |
GO:0046914 | transition metal ion binding | 0.000713132997593127 |
GO:0032501 | multicellular organismal process | 0.00531395199956216 |
GO:0044238 | primary metabolic process | 0.00566905222576778 |
GO:0044464 | cell part | 0.0104126099465675 |
GO:0046872 | metal ion binding | 0.0212378991688859 |
GO:0043169 | cation binding | 0.0212378991688859 |
GO:0044237 | cellular metabolic process | 0.0241679808359093 |
GO:0043167 | ion binding | 0.0274850187662175 |
GO:0009893 | positive regulation of metabolic process | 0.0297645329767371 |
GO:0010232 | vascular transport | 0.0297645329767371 |
GO:0018144 | RNA-protein covalent cross-linking | 0.0297645329767371 |
GO:0035067 | negative regulation of histone acetylation | 0.0297645329767371 |
GO:0051095 | regulation of helicase activity | 0.0297645329767371 |
GO:0051097 | negative regulation of helicase activity | 0.0297645329767371 |
GO:0018143 | nucleic acid-protein covalent cross-linking | 0.0297645329767371 |
GO:0031057 | negative regulation of histone modification | 0.0297645329767371 |
GO:0016929 | SUMO-specific protease activity | 0.0297645329767371 |
GO:0008326 | site-specific DNA-methyltransferase (cytosine-specific) activity | 0.0297645329767371 |
GO:0015326 | cationic amino acid transmembrane transporter activity | 0.0297645329767371 |
GO:0032444 | activin responsive factor complex | 0.0297645329767371 |
GO:0015819 | lysine transport | 0.0297645329767371 |
GO:0008401 | retinoic acid 4-hydroxylase activity | 0.0297645329767371 |
GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway | 0.0297645329767371 |
GO:0015181 | arginine transmembrane transporter activity | 0.0297645329767371 |
GO:0015189 | L-lysine transmembrane transporter activity | 0.0297645329767371 |
GO:0003682 | chromatin binding | 0.0304552529509428 |
GO:0007276 | gamete generation | 0.0366063061321303 |
GO:0019783 | small conjugating protein-specific protease activity | 0.046711025402069 |
GO:0048856 | anatomical structure development | 0.0475713832166307 |
GO:0016264 | gap junction assembly | 0.0475713832166307 |
GO:0042149 | cellular response to glucose starvation | 0.0475713832166307 |
GO:0015867 | ATP transport | 0.0475713832166307 |
GO:0051503 | adenine nucleotide transport | 0.0475713832166307 |
GO:0003691 | double-stranded telomeric DNA binding | 0.0475713832166307 |
GO:0015809 | arginine transport | 0.0475713832166307 |
GO:0015865 | purine nucleotide transport | 0.0475713832166307 |
GO:0045844 | positive regulation of striated muscle development | 0.0475713832166307 |
GO:0035065 | regulation of histone acetylation | 0.0475713832166307 |
GO:0000739 | DNA strand annealing activity | 0.0475713832166307 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
---|---|---|
embryonic stem cell | 4.19e-67 | 5 |
germ line cell | 4.81e-30 | 7 |
germ cell | 4.81e-30 | 7 |
neuron | 1.09e-20 | 6 |
neuroblast | 1.09e-20 | 6 |
electrically signaling cell | 1.09e-20 | 6 |
neuronal stem cell | 1.10e-15 | 8 |
melanocyte | 9.65e-13 | 10 |
melanoblast | 9.65e-13 | 10 |
pigment cell | 2.91e-09 | 14 |
neurectodermal cell | 1.28e-07 | 59 |
Ontology term | p-value | n |
---|---|---|
testis | 2.40e-26 | 8 |
male reproductive organ | 2.85e-19 | 11 |
gonad | 1.71e-15 | 21 |
indifferent external genitalia | 1.71e-15 | 21 |
indifferent gonad | 1.71e-15 | 21 |
gonad primordium | 1.71e-15 | 21 |
external genitalia | 8.64e-15 | 22 |
male organism | 8.69e-10 | 22 |
male reproductive system | 8.69e-10 | 22 |
body cavity | 4.72e-07 | 46 |
reproductive organ | 9.37e-07 | 48 |
Ontology term | p-value | n |
---|---|---|
germ cell and embryonal cancer | 5.51e-21 | 22 |
germ cell cancer | 5.51e-21 | 22 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 0.800809 |
MA0004.1 | 0.0771229 |
MA0006.1 | 0.10408 |
MA0007.1 | 0.550234 |
MA0009.1 | 0.837723 |
MA0014.1 | 1.31198 |
MA0017.1 | 0.203291 |
MA0019.1 | 0.248072 |
MA0024.1 | 1.29973 |
MA0025.1 | 0.0330094 |
MA0027.1 | 0.896654 |
MA0028.1 | 0.00252954 |
MA0029.1 | 0.689488 |
MA0030.1 | 0.463521 |
MA0031.1 | 0.17933 |
MA0038.1 | 0.368225 |
MA0040.1 | 0.522298 |
MA0041.1 | 0.109867 |
MA0042.1 | 1.70116 |
MA0043.1 | 0.00116511 |
MA0046.1 | 0.138702 |
MA0048.1 | 0.0202017 |
MA0050.1 | 0.00339647 |
MA0051.1 | 0.0294325 |
MA0052.1 | 0.372495 |
MA0055.1 | 2.99722e-08 |
MA0056.1 | 0 |
MA0057.1 | 4.20171 |
MA0058.1 | 0.0163497 |
MA0059.1 | 0.321565 |
MA0060.1 | 0.613184 |
MA0061.1 | 1.23003 |
MA0063.1 | 0 |
MA0066.1 | 0.0170395 |
MA0067.1 | 0.284846 |
MA0068.1 | 1.08773 |
MA0069.1 | 1.62701 |
MA0070.1 | 0.0218839 |
MA0071.1 | 0.397132 |
MA0072.1 | 0.117016 |
MA0073.1 | 4.48549 |
MA0074.1 | 1.04479 |
MA0076.1 | 0.00133405 |
MA0077.1 | 1.46421 |
MA0078.1 | 0.419086 |
MA0081.1 | 0.00524314 |
MA0083.1 | 0.079975 |
MA0084.1 | 0.277796 |
MA0087.1 | 0.499039 |
MA0088.1 | 0.331573 |
MA0089.1 | 0 |
MA0090.1 | 0.278446 |
MA0091.1 | 0.00544509 |
MA0092.1 | 0.0213306 |
MA0093.1 | 0.0612765 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.0110454 |
MA0101.1 | 0.0332303 |
MA0103.1 | 1.4114 |
MA0105.1 | 2.85393 |
MA0106.1 | 2.83741 |
MA0107.1 | 0.282091 |
MA0108.2 | 2.64195 |
MA0109.1 | 0 |
MA0111.1 | 0.347045 |
MA0113.1 | 0.0265107 |
MA0114.1 | 0.650424 |
MA0115.1 | 0.376626 |
MA0116.1 | 1.48343 |
MA0117.1 | 1.31058 |
MA0119.1 | 0.539458 |
MA0122.1 | 0.054912 |
MA0124.1 | 0.305514 |
MA0125.1 | 2.19786 |
MA0130.1 | 0 |
MA0131.1 | 0.110455 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.503105 |
MA0136.1 | 0.036603 |
MA0139.1 | 0.0161207 |
MA0140.1 | 3.22756 |
MA0141.1 | 0.108906 |
MA0142.1 | 17.2677 |
MA0143.1 | 11.6533 |
MA0144.1 | 0.201561 |
MA0145.1 | 0.070685 |
MA0146.1 | 0.0876199 |
MA0147.1 | 0.39746 |
MA0148.1 | 0.17347 |
MA0149.1 | 0.0350261 |
MA0062.2 | 0.00169708 |
MA0035.2 | 2.92124 |
MA0039.2 | 11.4989 |
MA0138.2 | 0.0502373 |
MA0002.2 | 0.0689023 |
MA0137.2 | 0.230987 |
MA0104.2 | 0.682583 |
MA0047.2 | 0.139088 |
MA0112.2 | 0.0502628 |
MA0065.2 | 5.64287 |
MA0150.1 | 0.0212582 |
MA0151.1 | 0 |
MA0152.1 | 0.415986 |
MA0153.1 | 0.303662 |
MA0154.1 | 1.50426 |
MA0155.1 | 2.36161 |
MA0156.1 | 0.00657359 |
MA0157.1 | 0.0508382 |
MA0158.1 | 0 |
MA0159.1 | 0.727413 |
MA0160.1 | 0.0273165 |
MA0161.1 | 0 |
MA0162.1 | 0.0958032 |
MA0163.1 | 1.80063 |
MA0164.1 | 0.158603 |
MA0080.2 | 0.0045609 |
MA0018.2 | 0.00126724 |
MA0099.2 | 0.00130439 |
MA0079.2 | 29.772 |
MA0102.2 | 0.0957963 |
MA0258.1 | 0.149814 |
MA0259.1 | 0.340788 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
TF | #promoters | Enrichment | p-value | q-value |
---|---|---|---|---|
BCL11A#53335 | 25 | 1.92204980376742 | 0.00162439411405001 | 0.0101678212093059 |
CTBP2#1488 | 17 | 2.88940109964384 | 0.000116215029985314 | 0.0015793599891524 |
NANOG#79923 | 78 | 6.18182309354739 | 3.33551519093832e-38 | 1.7956591290021e-35 |
POLR2A#5430 | 230 | 1.33852095015815 | 8.1705249827463e-10 | 7.68758070876613e-08 |
POU5F1#5460 | 34 | 30.9076770985496 | 2.57280266612752e-39 | 1.45243750079833e-36 |
SP1#6667 | 90 | 1.38984911661973 | 0.0005596376442309 | 0.00477633373586916 |
TAF1#6872 | 183 | 1.6579335238249 | 1.89067109621869e-15 | 3.47640490524619e-13 |
TAF7#6879 | 95 | 2.94347315302919 | 5.55656838565741e-22 | 1.54341075965339e-19 |
TBP#6908 | 148 | 1.48672645444516 | 3.06564915825508e-08 | 2.07231930381231e-06 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data