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MCL coexpression mm9:3616: Difference between revisions

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{{MCL_coexpression_mm9
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|ontology_enrichment_celltype=CL:0000221!1.71e-14!44;CL:0000133!1.71e-14!44;CL:0002319!2.63e-14!43;CL:0000540!3.78e-13!33;CL:0000047!3.78e-13!33;CL:0000031!3.78e-13!33;CL:0000404!3.78e-13!33;CL:0000117!4.54e-12!23;CL:0000337!4.54e-12!23;CL:0000055!7.09e-12!49;CL:0000393!1.95e-10!39;CL:0000211!1.95e-10!39
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0001017!7.82e-34!73;UBERON:0001016!7.22e-33!75;UBERON:0002346!4.58e-29!64;UBERON:0003075!4.58e-29!64;UBERON:0007284!4.58e-29!64;UBERON:0004121!9.54e-29!95;UBERON:0000924!9.54e-29!95;UBERON:0006601!9.54e-29!95;UBERON:0000073!4.10e-27!54;UBERON:0001049!1.23e-26!52;UBERON:0005068!1.23e-26!52;UBERON:0006241!1.23e-26!52;UBERON:0007135!1.23e-26!52;UBERON:0010371!9.04e-25!73;UBERON:0000955!1.27e-23!47;UBERON:0006238!1.27e-23!47;UBERON:0002616!6.95e-23!46;UBERON:0003056!2.23e-22!49;UBERON:0010314!5.95e-22!92;UBERON:0003080!4.08e-21!40;UBERON:0002780!1.10e-20!39;UBERON:0001890!1.10e-20!39;UBERON:0006240!1.10e-20!39;UBERON:0002020!8.90e-20!34;UBERON:0003528!1.62e-16!29;UBERON:0002791!1.62e-16!29;UBERON:0001893!1.62e-16!29;UBERON:0000956!3.03e-12!21;UBERON:0001869!3.03e-12!21;UBERON:0000203!3.03e-12!21;UBERON:0002619!5.04e-10!17;UBERON:0000025!1.30e-07!114;UBERON:0002021!1.93e-07!10;UBERON:0000411!1.93e-07!10;UBERON:0001950!1.93e-07!10;UBERON:0004111!5.12e-07!122;UBERON:0000468!5.38e-07!333
|tfbs_overrepresentation_for_novel_motifs=0.752782,1.07244,0.722405,0.801166,0.587814,0.81763,0.919454,0.467321,0.479531,1.23467,0.870507,0.906098,0.467629,0.933025,0.608226,0,1.14208,0.578045,0.448066,0.328717,0.679146,1.38557,0.932027,0.585919,0.731217,0.963352,0.437236,0.841386,0.64294,0.380786,0.825437,1.24901,0.575271,0.411696,1.47967,4.28298,1.38481,0.902078,0.536514,0.50014,0.582863,0.831295,0.724277,0.610669,0.156582,0.788421,1.05665,0.859154,0.235354,0.646474,1.12346,0.99279,0.371606,1.3966,1.41464,0.940919,0.657156,0.891887,0.425455,0.938668,1.22795,1.00308,0.494668,1.11142,0.953187,1.15459,1.55483,1.90983,1.22303,1.7608,0.700291,0.474956,1.41919,1.44925,1.07031,0.402065,0.411601,1.04436,1.20986,0.684144,0.476502,1.16055,1.00151,0.459035,1.32978,0.535545,0.195254,1.75916,1.06194,2.07346,1.62608,1.33496,1.26245,0.595071,1.31639,0.509215,0.464141,1.26539,1.05692,0.352122,0.563856,1.24872,1.37854,1.12409,1.12297,0.830796,1.18646,0.854628,0.689894,0.681267,1.76245,1.38039,0.685481,0.876299,1.63327,0.580657,1.1471,0.805461,1.14346,0.559153,1.45481,1.08896,0.965352,1.04338,1.68841,1.21376,0.928483,1.25534,1.55328,0.598722,1.36093,0.792832,1.52297,0.955954,1.65529,1.37701,0.762499,0.832891,1.60513,2.44352,2.04137,1.55966,0.978551,1.26,1.11604,0.831808,1.06002,2.40374,0.765221,0.589976,1.77018,1.32874,1.39822,0.516739,0.954936,1.48249,0.993889,0.622823,0.749933,0.762177,1.61484,1.32889,1.21423,0.741984,1.11251,0.94678,0.562367,0.904334,5.88251
|tfbs_overrepresentation_jaspar=MA0003.1;2.4568,MA0004.1;0.801718,MA0006.1;0.60285,MA0007.1;0.784593,MA0009.1;1.27673,MA0014.1;0.416365,MA0017.1;0.635031,MA0019.1;1.08369,MA0024.1;1.23079,MA0025.1;1.51835,MA0027.1;2.9431,MA0028.1;0.61552,MA0029.1;1.20789,MA0030.1;1.21482,MA0031.1;1.17722,MA0038.1;0.963265,MA0040.1;1.28983,MA0041.1;0.714279,MA0042.1;0.69885,MA0043.1;1.3775,MA0046.1;1.31428,MA0048.1;0.353763,MA0050.1;0.845669,MA0051.1;2.23119,MA0052.1;1.29825,MA0055.1;0.190475,MA0056.1;0,MA0057.1;6.5282,MA0058.1;0.690848,MA0059.1;0.705317,MA0060.1;0.502699,MA0061.1;1.33581,MA0063.1;0,MA0066.1;0.951196,MA0067.1;1.63197,MA0068.1;0.343188,MA0069.1;1.29861,MA0070.1;1.28847,MA0071.1;0.844726,MA0072.1;1.2796,MA0073.1;2.57794,MA0074.1;0.911576,MA0076.1;0.657929,MA0077.1;1.2569,MA0078.1;1.0091,MA0081.1;0.732313,MA0083.1;1.37668,MA0084.1;1.96428,MA0087.1;1.33189,MA0088.1;2.98794,MA0089.1;0,MA0090.1;0.762482,MA0091.1;0.816659,MA0092.1;0.762845,MA0093.1;0.62555,MA0095.1;0,MA0098.1;0,MA0100.1;0.89873,MA0101.1;0.71579,MA0103.1;0.647985,MA0105.1;3.76751,MA0106.1;1.01755,MA0107.1;0.640607,MA0108.2;1.10817,MA0109.1;0,MA0111.1;0.778753,MA0113.1;0.986839,MA0114.1;0.537669,MA0115.1;1.38041,MA0116.1;0.602598,MA0117.1;1.34691,MA0119.1;0.716476,MA0122.1;1.36752,MA0124.1;1.57762,MA0125.1;1.5017,MA0130.1;0,MA0131.1;1.07881,MA0132.1;0,MA0133.1;0,MA0135.1;1.4152,MA0136.1;0.933582,MA0139.1;2.03543,MA0140.1;0.898603,MA0141.1;0.671467,MA0142.1;1.16183,MA0143.1;1.00467,MA0144.1;0.541532,MA0145.1;0.794492,MA0146.1;0.46063,MA0147.1;0.556853,MA0148.1;0.820161,MA0149.1;4.16251,MA0062.2;0.412742,MA0035.2;0.903829,MA0039.2;2.07301,MA0138.2;1.07027,MA0002.2;0.466067,MA0137.2;0.668025,MA0104.2;0.48458,MA0047.2;0.962424,MA0112.2;0.29236,MA0065.2;7.16381,MA0150.1;0.784464,MA0151.1;0,MA0152.1;0.962542,MA0153.1;1.43238,MA0154.1;0.35067,MA0155.1;3.19927,MA0156.1;0.656895,MA0157.1;1.12772,MA0158.1;0,MA0159.1;0.569393,MA0160.1;0.823568,MA0161.1;0,MA0162.1;0.499274,MA0163.1;10.3705,MA0164.1;0.933981,MA0080.2;0.64167,MA0018.2;0.944669,MA0099.2;1.06348,MA0079.2;23.4162,MA0102.2;2.01714,MA0258.1;0.520639,MA0259.1;0.543506,MA0442.1;0
}}

Latest revision as of 20:23, 17 September 2013


Phase1 CAGE Peaks

 Short description
Mm9::chr7:25857276..25857305,-p6@Grik5
Mm9::chr7:25857306..25857385,-p2@Grik5
Mm9::chr9:58335890..58335917,+p1@6030419C18Rik


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008328ionotropic glutamate receptor complex0.014134662795157
GO:0005234extracellular-glutamate-gated ion channel activity0.014134662795157
GO:0004970ionotropic glutamate receptor activity0.014134662795157
GO:0005231excitatory extracellular ligand-gated ion channel activity0.0207308387662302
GO:0008066glutamate receptor activity0.0207308387662302
GO:0005230extracellular ligand-gated ion channel activity0.0217255002221857
GO:0043235receptor complex0.0217255002221857
GO:0015276ligand-gated ion channel activity0.0217255002221857
GO:0022834ligand-gated channel activity0.0217255002221857
GO:0045211postsynaptic membrane0.0256779707445351
GO:0044456synapse part0.0259135484577878



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
central nervous system7.82e-3473
nervous system7.22e-3375
neurectoderm4.58e-2964
neural plate4.58e-2964
presumptive neural plate4.58e-2964
ectoderm-derived structure9.54e-2995
ectoderm9.54e-2995
presumptive ectoderm9.54e-2995
regional part of nervous system4.10e-2754
neural tube1.23e-2652
neural rod1.23e-2652
future spinal cord1.23e-2652
neural keel1.23e-2652
ecto-epithelium9.04e-2573
brain1.27e-2347
future brain1.27e-2347
regional part of brain6.95e-2346
pre-chordal neural plate2.23e-2249
structure with developmental contribution from neural crest5.95e-2292
anterior neural tube4.08e-2140
regional part of forebrain1.10e-2039
forebrain1.10e-2039
future forebrain1.10e-2039
gray matter8.90e-2034
brain grey matter1.62e-1629
regional part of telencephalon1.62e-1629
telencephalon1.62e-1629
cerebral cortex3.03e-1221
cerebral hemisphere3.03e-1221
pallium3.03e-1221
regional part of cerebral cortex5.04e-1017
tube1.30e-07114
occipital lobe1.93e-0710
visual cortex1.93e-0710
neocortex1.93e-0710
anatomical conduit5.12e-07122
multi-cellular organism5.38e-07333


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.12.4568
MA0004.10.801718
MA0006.10.60285
MA0007.10.784593
MA0009.11.27673
MA0014.10.416365
MA0017.10.635031
MA0019.11.08369
MA0024.11.23079
MA0025.11.51835
MA0027.12.9431
MA0028.10.61552
MA0029.11.20789
MA0030.11.21482
MA0031.11.17722
MA0038.10.963265
MA0040.11.28983
MA0041.10.714279
MA0042.10.69885
MA0043.11.3775
MA0046.11.31428
MA0048.10.353763
MA0050.10.845669
MA0051.12.23119
MA0052.11.29825
MA0055.10.190475
MA0056.10
MA0057.16.5282
MA0058.10.690848
MA0059.10.705317
MA0060.10.502699
MA0061.11.33581
MA0063.10
MA0066.10.951196
MA0067.11.63197
MA0068.10.343188
MA0069.11.29861
MA0070.11.28847
MA0071.10.844726
MA0072.11.2796
MA0073.12.57794
MA0074.10.911576
MA0076.10.657929
MA0077.11.2569
MA0078.11.0091
MA0081.10.732313
MA0083.11.37668
MA0084.11.96428
MA0087.11.33189
MA0088.12.98794
MA0089.10
MA0090.10.762482
MA0091.10.816659
MA0092.10.762845
MA0093.10.62555
MA0095.10
MA0098.10
MA0100.10.89873
MA0101.10.71579
MA0103.10.647985
MA0105.13.76751
MA0106.11.01755
MA0107.10.640607
MA0108.21.10817
MA0109.10
MA0111.10.778753
MA0113.10.986839
MA0114.10.537669
MA0115.11.38041
MA0116.10.602598
MA0117.11.34691
MA0119.10.716476
MA0122.11.36752
MA0124.11.57762
MA0125.11.5017
MA0130.10
MA0131.11.07881
MA0132.10
MA0133.10
MA0135.11.4152
MA0136.10.933582
MA0139.12.03543
MA0140.10.898603
MA0141.10.671467
MA0142.11.16183
MA0143.11.00467
MA0144.10.541532
MA0145.10.794492
MA0146.10.46063
MA0147.10.556853
MA0148.10.820161
MA0149.14.16251
MA0062.20.412742
MA0035.20.903829
MA0039.22.07301
MA0138.21.07027
MA0002.20.466067
MA0137.20.668025
MA0104.20.48458
MA0047.20.962424
MA0112.20.29236
MA0065.27.16381
MA0150.10.784464
MA0151.10
MA0152.10.962542
MA0153.11.43238
MA0154.10.35067
MA0155.13.19927
MA0156.10.656895
MA0157.11.12772
MA0158.10
MA0159.10.569393
MA0160.10.823568
MA0161.10
MA0162.10.499274
MA0163.110.3705
MA0164.10.933981
MA0080.20.64167
MA0018.20.944669
MA0099.21.06348
MA0079.223.4162
MA0102.22.01714
MA0258.10.520639
MA0259.10.543506
MA0442.10
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