Coexpression cluster:C3209

Full id: C3209_renal_anaplastic_Fibroblast_mesenchymal_clear_mucinous_glioblastoma

Phase1 CAGE Peaks

Hg19::chr11:85430088..85430151,-	p2@SYTL2
Hg19::chr11:85430163..85430200,-	p3@SYTL2
Hg19::chr11:85430204..85430243,-	p5@SYTL2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	4.10e-29	180
muscle precursor cell	2.58e-13	57
myoblast	2.58e-13	57
multi-potent skeletal muscle stem cell	2.58e-13	57
electrically responsive cell	3.25e-13	60
electrically active cell	3.25e-13	60
muscle cell	2.51e-12	54
contractile cell	1.22e-10	59
skin fibroblast	1.82e-09	23
fibroblast	2.06e-09	75
smooth muscle cell	1.07e-08	42
smooth muscle myoblast	1.07e-08	42
vascular associated smooth muscle cell	5.18e-08	32

Uber Anatomy

Ontology term	p-value	n
organism subdivision	6.61e-27	365
epithelium	3.40e-18	309
cell layer	1.39e-17	312
central nervous system	1.78e-17	82
regional part of nervous system	8.33e-17	94
nervous system	8.33e-17	94
somite	6.50e-16	83
paraxial mesoderm	6.50e-16	83
presomitic mesoderm	6.50e-16	83
presumptive segmental plate	6.50e-16	83
trunk paraxial mesoderm	6.50e-16	83
presumptive paraxial mesoderm	6.50e-16	83
multi-tissue structure	3.55e-15	347
dermomyotome	4.93e-15	70
neural tube	1.68e-14	57
neural rod	1.68e-14	57
future spinal cord	1.68e-14	57
neural keel	1.68e-14	57
muscle tissue	4.76e-14	63
musculature	4.76e-14	63
musculature of body	4.76e-14	63
neural plate	4.88e-14	86
presumptive neural plate	4.88e-14	86
skeletal muscle tissue	8.29e-14	61
striated muscle tissue	8.29e-14	61
myotome	8.29e-14	61
brain	1.06e-13	69
future brain	1.06e-13	69
regional part of brain	3.82e-13	59
trunk mesenchyme	3.97e-13	143
neurectoderm	3.31e-12	90
adult organism	3.58e-12	115
telencephalon	8.46e-12	34
multilaminar epithelium	8.92e-12	82
gray matter	1.36e-11	34
brain grey matter	1.36e-11	34
cerebral hemisphere	1.64e-11	32
tube	3.01e-11	194
regional part of telencephalon	3.12e-11	33
multi-cellular organism	3.33e-11	659
ectoderm-derived structure	4.23e-11	169
regional part of forebrain	9.94e-11	41
forebrain	9.94e-11	41
future forebrain	9.94e-11	41
head	1.10e-10	123
anatomical system	1.42e-10	625
anterior region of body	1.96e-10	129
craniocervical region	1.96e-10	129
anatomical conduit	2.05e-10	241
anatomical group	2.15e-10	626
anatomical cluster	2.69e-10	286
anterior neural tube	4.15e-10	42
ectoderm	5.04e-10	173
presumptive ectoderm	5.04e-10	173
cerebral cortex	8.04e-10	25
pallium	8.04e-10	25
trunk	2.09e-09	216
pre-chordal neural plate	7.09e-09	61
regional part of cerebral cortex	1.83e-08	22
neocortex	7.20e-08	20
skin of body	4.79e-07	40
integument	7.73e-07	45
integumental system	7.73e-07	45

Disease

Ontology term	p-value	n
female reproductive organ cancer	1.57e-07	27
reproductive organ cancer	2.31e-07	29

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.