MCL coexpression mm9:850

Phase1 CAGE Peaks

	Short description
Mm9::chr5:77778509..77778520,-	p@chr5:77778509..77778520 -
Mm9::chr5:77780274..77780292,-	p@chr5:77780274..77780292 -
Mm9::chr5:77780308..77780326,-	p@chr5:77780308..77780326 -
Mm9::chr5:77780313..77780353,+	p@chr5:77780313..77780353 +
Mm9::chr5:77780374..77780389,-	p@chr5:77780374..77780389 -
Mm9::chr5:77784612..77784627,-	p@chr5:77784612..77784627 -
Mm9::chr5:77784669..77784700,-	p@chr5:77784669..77784700 -
Mm9::chr5:77837059..77837076,-	p1@Igfbp7
Mm9::chr5:91503637..91503655,+	p1@Ereg

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045740	positive regulation of DNA replication	0.00685564020990441
GO:0045741	positive regulation of epidermal growth factor receptor activity	0.00685564020990441
GO:0045840	positive regulation of mitosis	0.00685564020990441
GO:0048661	positive regulation of smooth muscle cell proliferation	0.00685564020990441
GO:0048660	regulation of smooth muscle cell proliferation	0.00685564020990441
GO:0051054	positive regulation of DNA metabolic process	0.00685564020990441
GO:0007176	regulation of epidermal growth factor receptor activity	0.00685564020990441
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	0.00799802779350924
GO:0048659	smooth muscle cell proliferation	0.00872464315354631
GO:0045410	positive regulation of interleukin-6 biosynthetic process	0.00872464315354631
GO:0042058	regulation of epidermal growth factor receptor signaling pathway	0.00872464315354631
GO:0005154	epidermal growth factor receptor binding	0.00933026551260013
GO:0045408	regulation of interleukin-6 biosynthetic process	0.00999589135654227
GO:0045088	regulation of innate immune response	0.00999589135654227
GO:0042226	interleukin-6 biosynthetic process	0.00999589135654227
GO:0045089	positive regulation of innate immune response	0.00999589135654227
GO:0006275	regulation of DNA replication	0.0101005577041794
GO:0007173	epidermal growth factor receptor signaling pathway	0.0101005577041794
GO:0045787	positive regulation of progression through cell cycle	0.0101005577041794
GO:0033002	muscle cell proliferation	0.010394872450425
GO:0032635	interleukin-6 production	0.0121834641934604
GO:0001819	positive regulation of cytokine production	0.0135284492854635
GO:0051052	regulation of DNA metabolic process	0.0135284492854635
GO:0005520	insulin-like growth factor binding	0.0135284492854635
GO:0045937	positive regulation of phosphate metabolic process	0.0135284492854635
GO:0042327	positive regulation of phosphorylation	0.0135284492854635
GO:0007088	regulation of mitosis	0.0159859761569069
GO:0001817	regulation of cytokine production	0.0171264229806767
GO:0042108	positive regulation of cytokine biosynthetic process	0.0176372799740115
GO:0009653	anatomical structure morphogenesis	0.01794974130003
GO:0045727	positive regulation of translation	0.0206197149518883
GO:0031328	positive regulation of cellular biosynthetic process	0.0214717333848699
GO:0019221	cytokine and chemokine mediated signaling pathway	0.0216168201433377
GO:0006261	DNA-dependent DNA replication	0.0216168201433377
GO:0019838	growth factor binding	0.0221887454538825
GO:0042035	regulation of cytokine biosynthetic process	0.0221887454538825
GO:0009891	positive regulation of biosynthetic process	0.0223625742343424
GO:0042325	regulation of phosphorylation	0.0223625742343424
GO:0051174	regulation of phosphorus metabolic process	0.0223625742343424
GO:0019220	regulation of phosphate metabolic process	0.0223625742343424
GO:0046982	protein heterodimerization activity	0.0226566428817888
GO:0042089	cytokine biosynthetic process	0.0226566428817888
GO:0042107	cytokine metabolic process	0.0226566428817888
GO:0009967	positive regulation of signal transduction	0.0235910456148225
GO:0051247	positive regulation of protein metabolic process	0.0251918946131021
GO:0001558	regulation of cell growth	0.0281075483487805
GO:0045087	innate immune response	0.0302198657704283
GO:0016049	cell growth	0.0305358863514335
GO:0050778	positive regulation of immune response	0.0305358863514335
GO:0002684	positive regulation of immune system process	0.0305358863514335
GO:0001816	cytokine production	0.0305358863514335
GO:0048856	anatomical structure development	0.0305358863514335
GO:0008361	regulation of cell size	0.0322027952423242
GO:0050776	regulation of immune response	0.0327664823161875
GO:0002682	regulation of immune system process	0.0327664823161875
GO:0051240	positive regulation of multicellular organismal process	0.0330112176730036
GO:0008285	negative regulation of cell proliferation	0.0330112176730036
GO:0006417	regulation of translation	0.0358619549827318
GO:0006260	DNA replication	0.0358619549827318
GO:0001525	angiogenesis	0.0358619549827318
GO:0031326	regulation of cellular biosynthetic process	0.0363152168251283
GO:0040008	regulation of growth	0.0376816538365442
GO:0008083	growth factor activity	0.0376816538365442
GO:0009889	regulation of biosynthetic process	0.0385801828165491
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0399384507060411
GO:0007067	mitosis	0.040165868369942
GO:0000087	M phase of mitotic cell cycle	0.040165868369942
GO:0048514	blood vessel morphogenesis	0.0404817835179124
GO:0008284	positive regulation of cell proliferation	0.0404817835179124
GO:0000074	regulation of progression through cell cycle	0.0404817835179124
GO:0048646	anatomical structure formation	0.0416962136761355
GO:0046983	protein dimerization activity	0.0437553539093223
GO:0001568	blood vessel development	0.0442396693255351
GO:0001944	vasculature development	0.0442831293334266
GO:0032502	developmental process	0.0459248752799093
GO:0000278	mitotic cell cycle	0.0468621075906306
GO:0051246	regulation of protein metabolic process	0.0470783212135285
GO:0000279	M phase	0.0470783212135285

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
trunk	3.28e-10	90
subdivision of trunk	4.93e-10	66
trunk region element	1.21e-08	79
splanchnic layer of lateral plate mesoderm	1.30e-07	33
abdomen element	3.75e-07	49
abdominal segment element	3.75e-07	49
abdominal segment of trunk	3.75e-07	49
abdomen	3.75e-07	49
compound organ	5.60e-07	43

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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