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{{Coexpression_clusters
{
|coexpression_dpi_cluster_scores_median=0,0,0

Latest revision as of 11:38, 17 September 2013


Full id: C1122_granulocyte_brain_acute_biphenotypic_occipital_duodenum_myelodysplastic



Phase1 CAGE Peaks

Hg19::chr10:77191203..77191214,+p2@C10orf11
Hg19::chr19:822044..822085,-p2@MIR3187
Hg19::chr19:822219..822240,-p5@MIR3187
Hg19::chr19:822261..822271,-p10@MIR3187
Hg19::chr19:822276..822295,-p6@MIR3187
Hg19::chr19:822320..822332,-p7@MIR3187
Hg19::chr5:79366406..79366421,+p@chr5:79366406..79366421
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
nervous system1.32e-2889
central nervous system1.69e-2781
neural tube3.87e-2656
neural rod3.87e-2656
future spinal cord3.87e-2656
neural keel3.87e-2656
regional part of nervous system7.75e-2453
regional part of brain7.75e-2453
brain7.15e-2368
future brain7.15e-2368
brain grey matter2.75e-2234
gray matter2.75e-2234
telencephalon3.86e-2234
cerebral hemisphere1.53e-2132
neurectoderm6.46e-2186
regional part of forebrain1.99e-1941
forebrain1.99e-1941
anterior neural tube1.99e-1941
future forebrain1.99e-1941
regional part of telencephalon2.36e-1932
neural plate2.37e-1982
presumptive neural plate2.37e-1982
regional part of cerebral cortex3.33e-1822
cerebral cortex1.23e-1525
pallium1.23e-1525
pre-chordal neural plate3.20e-1561
neocortex8.04e-1520
ecto-epithelium2.07e-13104
ectoderm-derived structure4.08e-13171
ectoderm4.08e-13171
presumptive ectoderm4.08e-13171
structure with developmental contribution from neural crest3.64e-11132
organ system subdivision1.65e-10223
adult organism1.64e-09114
neural nucleus3.35e-089
nucleus of brain3.35e-089
posterior neural tube6.93e-0815
chordal neural plate6.93e-0815
limbic system8.00e-085
parietal lobe3.02e-075
pons7.34e-073
Disease
Ontology termp-valuen
myeloid leukemia2.53e-1631
leukemia4.80e-1239
hematologic cancer3.28e-0851
immune system cancer3.28e-0851


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.16.06978
MA0004.10.502801
MA0006.10.341337
MA0007.10.483857
MA0009.10.973289
MA0014.17.00463
MA0017.10.380797
MA0019.10.652951
MA0024.10.867125
MA0025.11.10816
MA0027.12.59001
MA0028.10.35747
MA0029.10.886702
MA0030.10.875089
MA0031.10.809638
MA0038.10.60704
MA0040.10.892629
MA0041.10.521615
MA0042.10.48922
MA0043.10.973609
MA0046.10.962263
MA0048.10.382278
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.10.0407081
MA0056.10
MA0057.15.50125
MA0058.10.406232
MA0059.10.404929
MA0060.10.224688
MA0061.11.09187
MA0063.10
MA0066.10.607474
MA0067.11.29359
MA0068.17.33233
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.126.7061
MA0074.10.60198
MA0076.10.422297
MA0077.10.934645
MA0078.10.703614
MA0081.10.405093
MA0083.10.980893
MA0084.11.48179
MA0087.10.939982
MA0088.10.0723293
MA0089.10
MA0090.10.436918
MA0091.10.505453
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.10.621149
MA0101.11.64331
MA0103.10.332048
MA0105.13.6909
MA0106.10.648997
MA0107.12.1191
MA0108.20.806528
MA0109.10
MA0111.11.14351
MA0113.10.665691
MA0114.10.269076
MA0115.11.21667
MA0116.11.39213
MA0117.11.01134
MA0119.10.388712
MA0122.11.03753
MA0124.11.17486
MA0125.11.0901
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.186511
MA0140.10.564957
MA0141.10.403171
MA0142.10.777365
MA0143.10.66587
MA0144.10.708913
MA0145.10.980834
MA0146.10.828373
MA0147.10.281049
MA0148.10.528066
MA0149.12.34207
MA0062.20.193221
MA0035.20.564239
MA0039.22.64992
MA0138.20.704862
MA0002.20.611548
MA0137.20.36398
MA0104.20.223944
MA0047.20.636643
MA0112.20.944394
MA0065.20.282161
MA0150.10.430951
MA0151.10
MA0152.10.571637
MA0153.11.07307
MA0154.10.335384
MA0155.10.910701
MA0156.10.36627
MA0157.10.749547
MA0158.10
MA0159.10.281681
MA0160.10.543522
MA0161.10
MA0162.16.38454
MA0163.110.2402
MA0164.10.678332
MA0080.20.344472
MA0018.20.650405
MA0099.20.572
MA0079.228.2647
MA0102.21.51913
MA0258.10.245543
MA0259.10.289405
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90554.525858269259020.00155157330626470.0098549391554448
E2F6#187653.583682665498130.004598101897827240.0217216014161018
EGR1#195853.562985067721530.004722351211058930.02225621110703
ZBTB7A#5134155.251363791339930.0007687692483214460.00602955027977196



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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