MCL coexpression mm9:1823

Phase1 CAGE Peaks

	Short description
Mm9::chr6:146837003..146837110,+	p1@Ppfibp1
Mm9::chr6:146837115..146837127,+	p3@Ppfibp1
Mm9::chr8:131209646..131209682,+	p1@Itgb1
Mm9::chr8:131209686..131209718,+	p2@Itgb1
Mm9::chr8:26127215..26127349,-	p1@Adam9

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0007229	integrin-mediated signaling pathway	0.00690297485344875
GO:0042685	cardioblast cell fate specification	0.00690297485344875
GO:0042684	cardioblast cell fate commitment	0.00690297485344875
GO:0010002	cardioblast differentiation	0.0155299915344662
GO:0015074	DNA integration	0.0172536553033409
GO:0008907	integrase activity	0.0172536553033409
GO:0045214	sarcomere organization	0.0258663047178699
GO:0031594	neuromuscular junction	0.0258663047178699
GO:0030239	myofibril assembly	0.0258663047178699
GO:0055002	striated muscle cell development	0.0258663047178699
GO:0055001	muscle cell development	0.0258663047178699
GO:0035051	cardiac cell differentiation	0.0258663047178699
GO:0031032	actomyosin structure organization and biogenesis	0.0275771186494365
GO:0048628	myoblast maturation	0.0275771186494365
GO:0048627	myoblast development	0.0275771186494365
GO:0005178	integrin binding	0.0275771186494365
GO:0001708	cell fate specification	0.0275771186494365
GO:0000082	G1/S transition of mitotic cell cycle	0.0275771186494365
GO:0042383	sarcolemma	0.0299818981115443
GO:0051146	striated muscle cell differentiation	0.0299818981115443
GO:0008305	integrin complex	0.0334681497734881
GO:0045445	myoblast differentiation	0.0338223891700692
GO:0051325	interphase	0.0353002695801633
GO:0051329	interphase of mitotic cell cycle	0.0353002695801633
GO:0032403	protein complex binding	0.0404828395410406
GO:0019717	synaptosome	0.0413022244570754
GO:0042692	muscle cell differentiation	0.0440267199851479
GO:0007160	cell-matrix adhesion	0.0440267199851479
GO:0048741	skeletal muscle fiber development	0.0440267199851479
GO:0048747	muscle fiber development	0.0440267199851479
GO:0031589	cell-substrate adhesion	0.0445963435747367
GO:0043235	receptor complex	0.0462527062824946
GO:0048469	cell maturation	0.0462527062824946

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
cardiovascular system	5.31e-12	23
circulatory system	5.31e-12	23
splanchnic layer of lateral plate mesoderm	4.25e-10	33
primary circulatory organ	2.79e-09	18
heart	2.79e-09	18
primitive heart tube	2.79e-09	18
primary heart field	2.79e-09	18
anterior lateral plate mesoderm	2.79e-09	18
heart tube	2.79e-09	18
heart primordium	2.79e-09	18
cardiac mesoderm	2.79e-09	18
cardiogenic plate	2.79e-09	18
heart rudiment	2.79e-09	18
compound organ	4.71e-09	43
epithelial tube	1.34e-08	47
thoracic cavity element	1.38e-07	17
thoracic segment organ	1.38e-07	17
thoracic cavity	1.38e-07	17
thoracic segment of trunk	1.38e-07	17
respiratory primordium	1.38e-07	17
endoderm of foregut	1.38e-07	17
trunk	1.85e-07	90
epithelial fold	6.61e-07	20
subdivision of trunk	9.85e-07	66

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}