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Coexpression cluster:C2778: Difference between revisions

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|tf_chipseq_enrich=E2F1#1869;4:4.90738921487932:0.00172402235736179:0.0106705683880827
|tf_chipseq_enrich=E2F1#1869;4:4.90738921487932:0.00172402235736179:0.0106705683880827
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}}
}}

Revision as of 15:42, 26 November 2012


Full id: C2778_heart_Wilms_acute_CD34_Pancreatic_occipital_uterus



Phase1 CAGE Peaks

Hg19::chr4:143767428..143767464,-p2@INPP4B
Hg19::chr4:143767623..143767635,-p11@INPP4B
Hg19::chr4:143767658..143767669,-p12@INPP4B
Hg19::chr4:143767679..143767699,-p7@INPP4B


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism4.01e-47114
neural tube2.75e-2656
neural rod2.75e-2656
future spinal cord2.75e-2656
neural keel2.75e-2656
regional part of nervous system6.42e-2553
regional part of brain6.42e-2553
regional part of forebrain5.60e-2241
forebrain5.60e-2241
anterior neural tube5.60e-2241
future forebrain5.60e-2241
brain grey matter6.13e-2034
gray matter6.13e-2034
neural plate9.41e-2082
presumptive neural plate9.41e-2082
brain1.46e-1968
future brain1.46e-1968
telencephalon1.50e-1934
cerebral hemisphere3.87e-1932
regional part of telencephalon9.31e-1932
central nervous system1.51e-1881
neurectoderm1.13e-1786
organ system subdivision1.18e-15223
cerebral cortex4.05e-1525
pallium4.05e-1525
regional part of cerebral cortex6.07e-1522
nervous system2.24e-1489
ecto-epithelium3.14e-14104
pre-chordal neural plate6.79e-1461
neocortex1.84e-1320
structure with developmental contribution from neural crest2.38e-13132
organ7.87e-11503
multi-tissue structure7.49e-09342
anatomical cluster1.14e-08373
anatomical conduit5.44e-08240
organ part5.62e-08218
ectoderm-derived structure3.83e-07171
ectoderm3.83e-07171
presumptive ectoderm3.83e-07171


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186944.907389214879320.001724022357361790.0106705683880827



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.