MCL coexpression mm9:751

Phase1 CAGE Peaks

	Short description
Mm9::chr10:10408741..10408754,-	p@chr10:10408741..10408754 -
Mm9::chr15:59373755..59373758,-	p@chr15:59373755..59373758 -
Mm9::chr3:32848711..32848733,-	p@chr3:32848711..32848733 -
Mm9::chr4:134073493..134073502,-	p@chr4:134073493..134073502 -
Mm9::chr4:134073503..134073512,-	p@chr4:134073503..134073512 -
Mm9::chr5:116456786..116456790,+	p@chr5:116456786..116456790 +
Mm9::chrX:133371161..133371170,+	p@chrX:133371161..133371170 +
Mm9::chrX:133371502..133371513,+	p@chrX:133371502..133371513 +
Mm9::chrX:133372506..133372513,+	p@chrX:133372506..133372513 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0022010	myelination in the central nervous system	0.00827261272119652
GO:0032291	ensheathment of axons in the central nervous system	0.00827261272119652
GO:0050774	negative regulation of dendrite morphogenesis	0.00919078470315804
GO:0022008	neurogenesis	0.00919078470315804
GO:0042759	long-chain fatty acid biosynthetic process	0.00919078470315804
GO:0050773	regulation of dendrite development	0.00919078470315804
GO:0048814	regulation of dendrite morphogenesis	0.00919078470315804
GO:0014003	oligodendrocyte development	0.00919078470315804
GO:0043209	myelin sheath	0.00919078470315804
GO:0007091	mitotic metaphase/anaphase transition	0.0132336421865224
GO:0048709	oligodendrocyte differentiation	0.0132942095545633
GO:0021782	glial cell development	0.0132942095545633
GO:0007399	nervous system development	0.0132942095545633
GO:0048813	dendrite morphogenesis	0.0153583731899625
GO:0001676	long-chain fatty acid metabolic process	0.0154367110502175
GO:0000070	mitotic sister chromatid segregation	0.0165379735355587
GO:0000819	sister chromatid segregation	0.0165379735355587
GO:0050768	negative regulation of neurogenesis	0.018374015336697
GO:0000910	cytokinesis	0.0217557205028179
GO:0042552	myelination	0.0217928865253435
GO:0007272	ensheathment of neurons	0.0217928865253435
GO:0008366	axon ensheathment	0.0217928865253435
GO:0048468	cell development	0.0234178802114421
GO:0001726	ruffle	0.0234178802114421
GO:0001508	regulation of action potential	0.0238737809030668
GO:0010001	glial cell differentiation	0.0238737809030668
GO:0016358	dendrite development	0.0238737809030668
GO:0042063	gliogenesis	0.0242003900959857
GO:0050767	regulation of neurogenesis	0.024520714674303
GO:0019992	diacylglycerol binding	0.024520714674303
GO:0007059	chromosome segregation	0.024520714674303
GO:0006633	fatty acid biosynthetic process	0.0326644013582726
GO:0046394	carboxylic acid biosynthetic process	0.0326644013582726
GO:0016053	organic acid biosynthetic process	0.0326644013582726
GO:0048731	system development	0.0326644013582726
GO:0048469	cell maturation	0.0326644013582726
GO:0031252	leading edge	0.0326644013582726
GO:0048869	cellular developmental process	0.0326644013582726
GO:0030154	cell differentiation	0.0326644013582726
GO:0021700	developmental maturation	0.0375475861361743
GO:0048856	anatomical structure development	0.040054757706558
GO:0051093	negative regulation of developmental process	0.0408535308186507
GO:0007275	multicellular organismal development	0.0478439283110007

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
raphe nuclei neuron	1.49e-13	3
neuron of the substantia nigra	3.45e-13	3
CNS neuron (sensu Vertebrata)	5.37e-13	23
neuroblast (sensu Vertebrata)	5.37e-13	23
neuron	1.26e-08	33
neuronal stem cell	1.26e-08	33
neuroblast	1.26e-08	33
electrically signaling cell	1.26e-08	33
electrically responsive cell	4.41e-07	39
electrically active cell	4.41e-07	39

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	2.60e-23	54
neural tube	1.11e-18	52
neural rod	1.11e-18	52
future spinal cord	1.11e-18	52
neural keel	1.11e-18	52
central nervous system	2.09e-18	73
nervous system	7.96e-18	75
regional part of midbrain	1.25e-16	4
midbrain	1.25e-16	4
presumptive midbrain	1.25e-16	4
midbrain neural tube	1.25e-16	4
neurectoderm	1.38e-16	64
neural plate	1.38e-16	64
presumptive neural plate	1.38e-16	64
ectoderm-derived structure	5.72e-15	95
ectoderm	5.72e-15	95
presumptive ectoderm	5.72e-15	95
posterior neural tube	1.17e-14	12
chordal neural plate	1.17e-14	12
ecto-epithelium	3.76e-14	73
raphe nuclei	1.49e-13	3
reticular formation	1.49e-13	3
substantia nigra	3.45e-13	3
telencephalic nucleus	3.45e-13	3
midbrain nucleus	3.45e-13	3
neural nucleus	3.45e-13	3
nucleus of brain	3.45e-13	3
regional part of brain	3.70e-12	46
brain	7.53e-12	47
future brain	7.53e-12	47
structure with developmental contribution from neural crest	1.45e-10	92
spinal cord	2.84e-10	6
dorsal region element	2.84e-10	6
dorsum	2.84e-10	6
gray matter	6.64e-10	34
medulla oblongata	1.23e-08	2
brainstem	1.23e-08	2
myelencephalon	1.23e-08	2
future myelencephalon	1.23e-08	2
anterior neural tube	2.47e-08	40
pre-chordal neural plate	6.42e-08	49
regional part of spinal cord	2.73e-07	5
gray matter of spinal cord	2.73e-07	5
regional part of forebrain	6.06e-07	39
forebrain	6.06e-07	39
future forebrain	6.06e-07	39
tube	7.52e-07	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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