MCL coexpression mm9:1510

Phase1 CAGE Peaks

	Short description
Mm9::chr10:36226756..36226803,+	p2@Hs3st5
Mm9::chr11:33743676..33743687,-	p7@Kcnip1
Mm9::chr11:33743693..33743713,-	p4@Kcnip1
Mm9::chr6:114081373..114081432,+	p@chr6:114081373..114081432 +
Mm9::chr7:4072035..4072068,-	p1@ENSMUST00000050989 p1@ENSMUST00000132560 p1@ENSMUST00000149343

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005332	gamma-aminobutyric acid:sodium symporter activity	0.0172527099321138
GO:0015185	L-gamma-aminobutyric acid transmembrane transporter activity	0.0172527099321138
GO:0008467	heparin-glucosamine 3-O-sulfotransferase activity	0.0172527099321138
GO:0005283	sodium:amino acid symporter activity	0.0172527099321138
GO:0005416	cation:amino acid symporter activity	0.0206998488307872
GO:0008324	cation transmembrane transporter activity	0.0214356684575052
GO:0005328	neurotransmitter:sodium symporter activity	0.023645078476576
GO:0005343	organic acid:sodium symporter activity	0.023645078476576
GO:0005326	neurotransmitter transporter activity	0.023645078476576
GO:0015075	ion transmembrane transporter activity	0.023645078476576
GO:0015179	L-amino acid transmembrane transporter activity	0.024026836959118
GO:0022891	substrate-specific transmembrane transporter activity	0.0260457337476539
GO:0005275	amine transmembrane transporter activity	0.0278406913503091
GO:0015171	amino acid transmembrane transporter activity	0.0278406913503091
GO:0022857	transmembrane transporter activity	0.0278406913503091
GO:0015370	solute:sodium symporter activity	0.0280570260138593
GO:0022892	substrate-specific transporter activity	0.0280570260138593
GO:0008146	sulfotransferase activity	0.0280570260138593
GO:0006836	neurotransmitter transport	0.0284089374572476
GO:0016782	transferase activity, transferring sulfur-containing groups	0.0284089374572476
GO:0015294	solute:cation symporter activity	0.0284089374572476
GO:0046943	carboxylic acid transmembrane transporter activity	0.0289219912115317
GO:0005342	organic acid transmembrane transporter activity	0.0289219912115317

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	5.05e-18	23
neuroblast (sensu Vertebrata)	5.05e-18	23
neuron	9.08e-12	33
neuronal stem cell	9.08e-12	33
neuroblast	9.08e-12	33
electrically signaling cell	9.08e-12	33
ectodermal cell	3.35e-09	44
neurectodermal cell	3.35e-09	44
neural cell	5.38e-09	43
electrically responsive cell	1.27e-08	39
electrically active cell	1.27e-08	39
non-terminally differentiated cell	7.84e-07	49

Uber Anatomy

Ontology term	p-value	n
neurectoderm	1.68e-32	64
neural plate	1.68e-32	64
presumptive neural plate	1.68e-32	64
regional part of nervous system	1.72e-31	54
neural tube	1.07e-29	52
neural rod	1.07e-29	52
future spinal cord	1.07e-29	52
neural keel	1.07e-29	52
central nervous system	1.48e-29	73
nervous system	3.55e-28	75
ectoderm-derived structure	6.77e-28	95
ectoderm	6.77e-28	95
presumptive ectoderm	6.77e-28	95
ecto-epithelium	1.06e-27	73
pre-chordal neural plate	1.60e-26	49
brain	1.07e-24	47
future brain	1.07e-24	47
structure with developmental contribution from neural crest	8.54e-24	92
regional part of brain	1.11e-23	46
gray matter	2.14e-22	34
anterior neural tube	1.91e-21	40
regional part of forebrain	1.85e-20	39
forebrain	1.85e-20	39
future forebrain	1.85e-20	39
brain grey matter	1.79e-17	29
regional part of telencephalon	1.79e-17	29
telencephalon	1.79e-17	29
cerebral cortex	1.36e-11	21
cerebral hemisphere	1.36e-11	21
pallium	1.36e-11	21
regional part of cerebral cortex	9.23e-10	17
occipital lobe	8.74e-09	10
visual cortex	8.74e-09	10
neocortex	8.74e-09	10
posterior neural tube	1.23e-08	12
chordal neural plate	1.23e-08	12
basal ganglion	3.07e-07	8
nuclear complex of neuraxis	3.07e-07	8
aggregate regional part of brain	3.07e-07	8
collection of basal ganglia	3.07e-07	8
cerebral subcortex	3.07e-07	8
spinal cord	3.18e-07	6
dorsal region element	3.18e-07	6
dorsum	3.18e-07	6

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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