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Coexpression cluster:C3155

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Full id: C3155_medulla_spinal_diencephalon_corpus_locus_globus_parietal



Phase1 CAGE Peaks

Hg19::chr11:45922629..45922637,+p@chr11:45922629..45922637
+
Hg19::chr17:76492734..76492735,+p3@uc002jvt.1
Hg19::chr1:156589297..156589300,+p9@HAPLN2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005540hyaluronic acid binding0.0079477216531261
GO:0005539glycosaminoglycan binding0.00841133874955846
GO:0030247polysaccharide binding0.00841133874955846
GO:0001871pattern binding0.00841133874955846
GO:0005578proteinaceous extracellular matrix0.0211056163899682
GO:0030246carbohydrate binding0.0211056163899682
GO:0044421extracellular region part0.0282585658777817
GO:0022610biological adhesion0.0282585658777817
GO:0007155cell adhesion0.0282585658777817



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube1.05e-8057
neural rod1.05e-8057
future spinal cord1.05e-8057
neural keel1.05e-8057
regional part of brain9.60e-6859
brain3.04e-6069
future brain3.04e-6069
central nervous system3.62e-5782
neural plate9.96e-5586
presumptive neural plate9.96e-5586
regional part of forebrain4.90e-5341
forebrain4.90e-5341
future forebrain4.90e-5341
neurectoderm5.34e-5290
anterior neural tube1.12e-5142
regional part of nervous system1.61e-4894
nervous system1.61e-4894
gray matter3.55e-4834
brain grey matter3.55e-4834
telencephalon4.26e-4834
adult organism6.15e-45115
regional part of telencephalon1.16e-4433
cerebral hemisphere7.37e-4132
pre-chordal neural plate2.51e-3761
head1.13e-35123
anterior region of body1.06e-33129
craniocervical region1.06e-33129
regional part of cerebral cortex5.77e-3122
posterior neural tube7.26e-3015
chordal neural plate7.26e-3015
neocortex3.49e-2920
brainstem1.35e-288
ectoderm-derived structure1.27e-27169
cerebral cortex4.58e-2725
pallium4.58e-2725
ectoderm8.06e-27173
presumptive ectoderm8.06e-27173
nucleus of brain8.78e-259
neural nucleus8.78e-259
segmental subdivision of hindbrain6.34e-2412
hindbrain6.34e-2412
presumptive hindbrain6.34e-2412
segmental subdivision of nervous system5.50e-2213
tube8.11e-22194
gyrus9.15e-196
telencephalic nucleus1.56e-167
anatomical conduit4.15e-16241
brainstem nucleus3.76e-153
pons3.94e-153
medulla oblongata5.75e-153
myelencephalon5.75e-153
future myelencephalon5.75e-153
middle temporal gyrus5.27e-143
epithelium8.62e-14309
cell layer1.39e-13312
anatomical cluster2.04e-13286
organism subdivision3.44e-13365
regional part of metencephalon7.56e-139
metencephalon7.56e-139
future metencephalon7.56e-139
basal ganglion8.35e-139
nuclear complex of neuraxis8.35e-139
aggregate regional part of brain8.35e-139
collection of basal ganglia8.35e-139
cerebral subcortex8.35e-139
organ part4.33e-12219
globus pallidus1.14e-102
pallidum1.14e-102
locus ceruleus1.19e-102
hindbrain nucleus1.19e-102
dorsal plus ventral thalamus2.42e-102
temporal lobe2.81e-097
parietal lobe3.10e-095
occipital lobe6.69e-095
spinal cord1.38e-073
organ5.18e-07511


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.