MCL coexpression mm9:2843

Phase1 CAGE Peaks

	Short description
Mm9::chr13:43218194..43218199,+	p27@Phactr1
Mm9::chr13:43218218..43218238,+	p7@Phactr1
Mm9::chr4:86221700..86221711,+	p6@Rraga

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042268	regulation of cytolysis	0.00942285039103686
GO:0004864	protein phosphatase inhibitor activity	0.0270751097280139
GO:0019212	phosphatase inhibitor activity	0.0270751097280139
GO:0019835	cytolysis	0.0270751097280139
GO:0019888	protein phosphatase regulator activity	0.0274584677552507
GO:0019208	phosphatase regulator activity	0.0274584677552507

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
autonomic neuron	6.25e-10	9

Uber Anatomy

Ontology term	p-value	n
autonomic nervous system	6.25e-10	9
peripheral nervous system	1.37e-09	11
urinary system structure	1.93e-08	18
renal system	9.25e-08	19
ectodermal placode	6.40e-07	13
kidney	6.46e-07	14
kidney mesenchyme	6.46e-07	14
upper urinary tract	6.46e-07	14
kidney rudiment	6.46e-07	14
kidney field	6.46e-07	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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