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Coexpression cluster:C1266

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Full id: C1266_aorta_retina_eye_neuroectodermal_tongue_trachea_spleen



Phase1 CAGE Peaks

Hg19::chr2:183730840..183730851,-p7@FRZB
Hg19::chr2:183731087..183731115,+p@chr2:183731087..183731115
+
Hg19::chr2:183731285..183731309,-p2@FRZB
Hg19::chr2:183731311..183731323,-p5@FRZB
Hg19::chr2:183731332..183731352,-p4@FRZB
Hg19::chr2:183731355..183731384,-p3@FRZB
Hg19::chr2:183731495..183731507,-p6@FRZB


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism3.48e-49115
regional part of nervous system1.99e-3394
nervous system1.99e-3394
neurectoderm2.36e-3190
central nervous system1.78e-3082
neural tube2.73e-2957
neural rod2.73e-2957
future spinal cord2.73e-2957
neural keel2.73e-2957
neural plate3.43e-2986
presumptive neural plate3.43e-2986
regional part of brain1.18e-2859
brain3.95e-2769
future brain3.95e-2769
anterior region of body1.88e-26129
craniocervical region1.88e-26129
ectoderm6.95e-26173
presumptive ectoderm6.95e-26173
head2.05e-25123
ectoderm-derived structure4.90e-24169
anterior neural tube2.56e-2142
pre-chordal neural plate1.08e-2061
regional part of forebrain1.24e-2041
forebrain1.24e-2041
future forebrain1.24e-2041
telencephalon6.57e-1734
gray matter8.89e-1734
brain grey matter8.89e-1734
regional part of telencephalon1.98e-1633
multi-tissue structure2.53e-16347
cerebral hemisphere4.58e-1632
organism subdivision3.92e-15365
cerebral cortex5.33e-1325
pallium5.33e-1325
regional part of cerebral cortex4.96e-1222
neocortex2.34e-1120
embryo1.71e-10612
multi-cellular organism5.63e-10659
anatomical cluster3.26e-09286
posterior neural tube4.33e-0915
chordal neural plate4.33e-0915
cell layer5.52e-09312
epithelium1.61e-08309
organ part2.76e-08219
embryonic structure2.76e-08605
developing anatomical structure2.76e-08605
segmental subdivision of nervous system4.77e-0813
germ layer5.77e-08604
embryonic tissue5.77e-08604
presumptive structure5.77e-08604
epiblast (generic)5.77e-08604
segmental subdivision of hindbrain2.14e-0712
hindbrain2.14e-0712
presumptive hindbrain2.14e-0712


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.