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Coexpression cluster:C2598

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Full id: C2598_anaplastic_substantia_thalamus_globus_locus_corpus_spinal



Phase1 CAGE Peaks

Hg19::chr1:66458072..66458109,+p7@PDE4B
Hg19::chr1:66628017..66628018,+p@chr1:66628017..66628018
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Hg19::chr1:66738486..66738490,+p@chr1:66738486..66738490
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Hg19::chr5:135211849..135211853,+p@chr5:135211849..135211853
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube6.51e-4757
neural rod6.51e-4757
future spinal cord6.51e-4757
neural keel6.51e-4757
regional part of nervous system1.12e-4394
nervous system1.12e-4394
central nervous system1.66e-4382
regional part of brain3.77e-3859
anterior neural tube6.94e-3742
brain2.37e-3669
future brain2.37e-3669
regional part of forebrain4.17e-3641
forebrain4.17e-3641
future forebrain4.17e-3641
neural plate9.36e-3586
presumptive neural plate9.36e-3586
neurectoderm1.80e-3490
gray matter2.99e-3434
brain grey matter2.99e-3434
telencephalon3.75e-3434
regional part of telencephalon3.19e-3333
cerebral hemisphere5.42e-3232
pre-chordal neural plate7.21e-2761
adult organism1.65e-26115
cerebral cortex3.74e-2525
pallium3.74e-2525
ectoderm3.18e-24173
presumptive ectoderm3.18e-24173
ectoderm-derived structure5.67e-24169
regional part of cerebral cortex6.87e-2322
anterior region of body2.61e-22129
craniocervical region2.61e-22129
head6.44e-22123
neocortex8.38e-2120
posterior neural tube5.84e-1115
chordal neural plate5.84e-1115
nucleus of brain1.81e-109
neural nucleus1.81e-109
basal ganglion2.12e-109
nuclear complex of neuraxis2.12e-109
aggregate regional part of brain2.12e-109
collection of basal ganglia2.12e-109
cerebral subcortex2.12e-109
brainstem2.07e-098
organ part4.25e-09219
segmental subdivision of nervous system5.31e-0913
temporal lobe5.72e-097
organ8.56e-09511
telencephalic nucleus1.89e-087
segmental subdivision of hindbrain3.96e-0812
hindbrain3.96e-0812
presumptive hindbrain3.96e-0812
organism subdivision4.14e-08365
gyrus3.45e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.