MCL coexpression mm9:617

Phase1 CAGE Peaks

	Short description
Mm9::chr14:24823506..24823522,-	p2@Kcnma1
Mm9::chr15:39325197..39325201,+	p@chr15:39325197..39325201 +
Mm9::chr2:164821483..164821487,+	p@chr2:164821483..164821487 +
Mm9::chr2:77358766..77358770,-	p@chr2:77358766..77358770 -
Mm9::chr2:77654650..77654685,-	p3@Zfp385b
Mm9::chr2:77654793..77654805,-	p7@Zfp385b
Mm9::chr2:77654815..77654872,-	p2@Zfp385b
Mm9::chr5:148770934..148770945,+	p@chr5:148770934..148770945 +
Mm9::chr5:34562809..34562811,-	p@chr5:34562809..34562811 -
Mm9::chr7:82344162..82344165,-	p@chr7:82344162..82344165 -
Mm9::chr9:40183798..40183848,-	p12@Gramd1b
Mm9::chr9:40184415..40184432,-	p27@Gramd1b

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0032344	regulation of aldosterone metabolic process	0.00598257820632225
GO:0060082	eye blink reflex	0.00598257820632225
GO:0045794	negative regulation of cell volume	0.00598257820632225
GO:0019228	generation of action potential	0.00598257820632225
GO:0060072	large conductance calcium-activated potassium channel activity	0.00598257820632225
GO:0032341	aldosterone metabolic process	0.00747740333140966
GO:0008212	mineralocorticoid metabolic process	0.00747740333140966
GO:0060083	smooth muscle contraction involved in micturition	0.00747740333140966
GO:0045475	locomotor rhythm	0.00747740333140966
GO:0046541	saliva secretion	0.00747740333140966
GO:0060087	relaxation of vascular smooth muscle	0.00747740333140966
GO:0032350	regulation of hormone metabolic process	0.00747740333140966
GO:0006884	regulation of cell volume	0.00920245371152283
GO:0048512	circadian behavior	0.00934572995597631
GO:0060073	micturition	0.00934572995597631
GO:0045986	negative regulation of smooth muscle contraction	0.00934572995597631
GO:0043195	terminal button	0.00996823240522129
GO:0045932	negative regulation of muscle contraction	0.00996823240522129
GO:0019218	regulation of steroid metabolic process	0.0104660705212238
GO:0007622	rhythmic behavior	0.0104660705212238
GO:0060004	reflex	0.0113910171841284
GO:0033267	axon part	0.0122317288545561
GO:0007589	fluid secretion	0.0137025647441517
GO:0015269	calcium-activated potassium channel activity	0.0137025647441517
GO:0022600	digestive system process	0.0144304228663273
GO:0022839	ion gated channel activity	0.0144304228663273
GO:0005227	calcium activated cation channel activity	0.0144304228663273
GO:0042311	vasodilation	0.0144304228663273
GO:0003014	renal system process	0.0144304228663273
GO:0006940	regulation of smooth muscle contraction	0.0169357831169092
GO:0019216	regulation of lipid metabolic process	0.0183156324409287
GO:0051260	protein homooligomerization	0.0190146248393245
GO:0001666	response to hypoxia	0.0190146248393245
GO:0007628	adult walking behavior	0.0193331386871007
GO:0042491	auditory receptor cell differentiation	0.0196333582008793
GO:0006939	smooth muscle contraction	0.0215741766630153
GO:0060113	inner ear receptor cell differentiation	0.0217972456042262
GO:0051241	negative regulation of multicellular organismal process	0.0220695770245465
GO:0007623	circadian rhythm	0.0220695770245465
GO:0051259	protein oligomerization	0.0220695770245465
GO:0050885	neuromuscular process controlling balance	0.0220695770245465
GO:0042490	mechanoreceptor differentiation	0.0220695770245465
GO:0006937	regulation of muscle contraction	0.0220695770245465
GO:0003018	vascular process in circulatory system	0.0220695770245465
GO:0035150	regulation of tube size	0.0220695770245465
GO:0050880	regulation of blood vessel size	0.0220695770245465
GO:0007586	digestion	0.0254034203893136
GO:0008344	adult locomotory behavior	0.0255820679322074
GO:0042391	regulation of membrane potential	0.0255820679322074
GO:0050905	neuromuscular process	0.0280473105145699
GO:0016324	apical plasma membrane	0.0286643199364667
GO:0008076	voltage-gated potassium channel complex	0.0309732709122608
GO:0030534	adult behavior	0.0342297737221806
GO:0030424	axon	0.0342297737221806
GO:0044463	cell projection part	0.0365964280469895
GO:0050878	regulation of body fluid levels	0.0365964280469895
GO:0048839	inner ear development	0.0365964280469895
GO:0048469	cell maturation	0.0380122815999812
GO:0043583	ear development	0.0382285833979674
GO:0045177	apical part of cell	0.0382285833979674
GO:0042445	hormone metabolic process	0.038619253433346
GO:0003012	muscle system process	0.038619253433346
GO:0005249	voltage-gated potassium channel activity	0.038619253433346
GO:0006936	muscle contraction	0.038619253433346
GO:0021700	developmental maturation	0.0414892090984599
GO:0007605	sensory perception of sound	0.0414892090984599
GO:0008015	blood circulation	0.0415752100295672
GO:0003013	circulatory system process	0.0415752100295672
GO:0050954	sensory perception of mechanical stimulus	0.0418306613280087
GO:0045211	postsynaptic membrane	0.0460676981297058
GO:0030955	potassium ion binding	0.0460676981297058
GO:0022843	voltage-gated cation channel activity	0.0472339476899721
GO:0043005	neuron projection	0.0472339476899721
GO:0044456	synapse part	0.0483364338596647
GO:0005267	potassium channel activity	0.0483364338596647
GO:0006461	protein complex assembly	0.0488653389425182

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
neurectoderm	8.13e-18	64
neural plate	8.13e-18	64
presumptive neural plate	8.13e-18	64
regional part of nervous system	3.67e-16	54
neural tube	6.20e-16	52
neural rod	6.20e-16	52
future spinal cord	6.20e-16	52
neural keel	6.20e-16	52
ecto-epithelium	1.69e-15	73
pre-chordal neural plate	2.49e-14	49
brain	3.14e-14	47
future brain	3.14e-14	47
regional part of brain	2.43e-13	46
occipital lobe	1.74e-11	10
visual cortex	1.74e-11	10
neocortex	1.74e-11	10
gray matter	2.06e-11	34
ectoderm-derived structure	2.87e-11	95
ectoderm	2.87e-11	95
presumptive ectoderm	2.87e-11	95
anterior neural tube	3.98e-11	40
central nervous system	8.84e-11	73
regional part of forebrain	2.15e-10	39
forebrain	2.15e-10	39
future forebrain	2.15e-10	39
nervous system	3.55e-10	75
structure with developmental contribution from neural crest	3.57e-10	92
brain grey matter	1.06e-09	29
regional part of telencephalon	1.06e-09	29
telencephalon	1.06e-09	29
regional part of cerebral cortex	4.74e-08	17
cerebral cortex	4.38e-07	21
cerebral hemisphere	4.38e-07	21
pallium	4.38e-07	21

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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