MCL coexpression mm9:1982

Phase1 CAGE Peaks

	Short description
Mm9::chr11:68666621..68666642,-	p2@Ndel1
Mm9::chr11:97141940..97141964,-	p3@Npepps
Mm9::chr2:132403980..132403991,-	p3@Gpcpd1
Mm9::chr5:130505255..130505266,+	p3@Crcp

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001635	calcitonin gene-related polypeptide receptor activity	0.0251163494431265
GO:0008090	retrograde axon cargo transport	0.0251163494431265
GO:0047496	vesicle transport along microtubule	0.0251163494431265
GO:0001833	inner cell mass cell proliferation	0.0251163494431265
GO:0060053	neurofilament cytoskeleton	0.0251163494431265
GO:0021955	central nervous system neuron axonogenesis	0.0251163494431265
GO:0060052	neurofilament cytoskeleton organization and biogenesis	0.0251163494431265
GO:0008088	axon cargo transport	0.0251163494431265
GO:0004179	membrane alanyl aminopeptidase activity	0.0251163494431265
GO:0016284	alanine aminopeptidase activity	0.0251163494431265
GO:0001832	blastocyst growth	0.026981550297944
GO:0045104	intermediate filament cytoskeleton organization and biogenesis	0.0316028594612309
GO:0001633	secretin-like receptor activity	0.0316028594612309
GO:0045103	intermediate filament-based process	0.0319487487684913
GO:0021954	central nervous system neuron development	0.0319487487684913
GO:0001669	acrosome	0.0322119285064847
GO:0021953	central nervous system neuron differentiation	0.0322119285064847
GO:0001824	blastocyst development	0.0392804948935897
GO:0003899	DNA-directed RNA polymerase activity	0.0408076563027618
GO:0004177	aminopeptidase activity	0.0421809771009908
GO:0005813	centrosome	0.0455885569561132
GO:0008017	microtubule binding	0.0463997002075004
GO:0048589	developmental growth	0.0463997002075004
GO:0005815	microtubule organizing center	0.0463997002075004
GO:0015631	tubulin binding	0.0463997002075004
GO:0001764	neuron migration	0.0463997002075004
GO:0008235	metalloexopeptidase activity	0.0463997002075004

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	7.59e-10	23
neuroblast (sensu Vertebrata)	7.59e-10	23

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	4.30e-20	54
neural tube	7.38e-19	52
neural rod	7.38e-19	52
future spinal cord	7.38e-19	52
neural keel	7.38e-19	52
neurectoderm	1.12e-18	64
neural plate	1.12e-18	64
presumptive neural plate	1.12e-18	64
ecto-epithelium	6.06e-18	73
structure with developmental contribution from neural crest	2.18e-16	92
pre-chordal neural plate	3.54e-16	49
brain	4.37e-16	47
future brain	4.37e-16	47
regional part of brain	1.15e-15	46
ectoderm-derived structure	2.51e-15	95
ectoderm	2.51e-15	95
presumptive ectoderm	2.51e-15	95
gray matter	3.87e-15	34
anterior neural tube	7.63e-15	40
regional part of forebrain	2.90e-14	39
forebrain	2.90e-14	39
future forebrain	2.90e-14	39
central nervous system	3.14e-14	73
nervous system	9.30e-14	75
brain grey matter	1.10e-12	29
regional part of telencephalon	1.10e-12	29
telencephalon	1.10e-12	29
cerebral cortex	9.88e-09	21
cerebral hemisphere	9.88e-09	21
pallium	9.88e-09	21
occipital lobe	1.03e-07	10
visual cortex	1.03e-07	10
neocortex	1.03e-07	10
regional part of cerebral cortex	3.73e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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