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UBERON:0001769

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Name:iris
Definition:"a membrane in the eye, responsible for controlling the amount of light reaching the retina. The iris consists of pigmented fibrovascular tissue known as a stroma. It is the most forward portion of the eye and the only one seen on superficial inspection. The stroma connects a sphincter muscle (sphincter pupillae), which contracts the pupil, and a set of dilator muscles (dilator pupillae) which open it. The back surface is covered by a heavily pigmented epithelial layer two cells thick (the iris pigment epithelium), but the front surface has no epithelium. The high pigment content blocks light from passing through the iris and restricts it to the pupil. The outer edge of the iris, known as the root, is attached to the sclera and the anterior ciliary body. The iris and ciliary body together are known as the anterior uvea. Just in front of the root of the iris is the region through which the aqueous humour constantly drains out of the eye, with the result that diseases of the iris often have important effects on intraocular pressure, and indirectly on vision. Depending on the amount of light, the iris makes the pupil larger or smaller." [Wikipedia:Iris_(anatomy)]
Xrefs:
links:

AAO:0010347
BTO:0000653
EMAPA:19154
EV:0100345
FMA:58235
GAID:917
MA:0000273
MESH:A.09.371.894.513
ncithesaurus:Iris
OpenCyc:Mx4rvVjbppwpEbGdrcN5Y29ycA
SCTID:181164000
TAO:0001238
VHOG:0000101
XAO:0000185

ZFA:0001238
Synonyms: "anterior uvea" RELATED []
Comments:AO notes: MA and FMA differ regarding isa vs partof to vascular layer. Taxon notes: The avian iris and ciliary body undergoes a transition from smooth-to-striated muscle during embryonic development - dx.doi.org/10.1006/dbio.1998.9019
Alt_id: UBERON:FMA_58235-MA_0000273-XAO_0000185-ZFA_0001238
Subset: uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0001768(uvea)
develops_from:UBERON:0004128(optic vesicle)
part_of:UBERON:0001801(anterior segment of eyeball)



Children

part of:UBERON:0002506 (iris epithelium)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001769 (iris), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
9.37e-99FFCP PHASE2:Hg19::chr15:71583868..71583874,-#_e107c7813e3201f1da98f2e4180dff6cp@chr15:71583868..71583874, -
9.37e-99FFCP PHASE1:Hg19::chr15:71583868..71583874,-#_e107c7813e3201f1da98f2e4180dff6cp@chr15:71583868..71583874, -
1.23e-66FFCP PHASE1:Hg19::chr5:78112479..78112482,+#_7e81bdc2dac51427f5220c5777374274p@chr5:78112479..78112482, +
1.23e-66FFCP PHASE2:Hg19::chr5:78112479..78112482,+#_7e81bdc2dac51427f5220c5777374274p@chr5:78112479..78112482, +
2.39e-66FFCP PHASE2:Hg19::chr15:74495062..74495063,-#_adca04fdf1c42c926cb3859be4742089p13@STRA6
2.39e-66FFCP PHASE1:Hg19::chr15:74495062..74495063,-#_adca04fdf1c42c926cb3859be4742089p13@STRA6
4.66e-66FFCP PHASE1:Hg19::chr22:50667406..50667412,+#_41438aacf8bff5a6b9305cf98f7a33abp@chr22:50667406..50667412, +
4.66e-66FFCP PHASE2:Hg19::chr22:50667406..50667412,+#_41438aacf8bff5a6b9305cf98f7a33abp@chr22:50667406..50667412, +
1.46e-50FFCP PHASE1:Hg19::chr8:53853688..53853698,-#_aef5f1aa06572a23873cb392c67688a5p3@BC033145
1.46e-50FFCP PHASE2:Hg19::chr8:53853688..53853698,-#_aef5f1aa06572a23873cb392c67688a5p3@BC033145
2.42e-50FFCP PHASE1:Hg19::chr7:115723897..115723915,-#_f34c04affbdac6d659fd3e980bd1b954p@chr7:115723897..115723915, -
2.42e-50FFCP PHASE2:Hg19::chr7:115723897..115723915,-#_f34c04affbdac6d659fd3e980bd1b954p@chr7:115723897..115723915, -
6.58e-50FFCP PHASE2:Hg19::chr14:100847969..100847980,+#_ac18faca278893b8830802d30379ba9cp6@WDR25
6.58e-50FFCP PHASE1:Hg19::chr14:100847969..100847980,+#_ac18faca278893b8830802d30379ba9cp6@WDR25
6.62e-41FFCP PHASE2:Hg19::chr2:35680607..35680613,-#_aa0ab79bbc6ca3ededc7156b531078c1p@chr2:35680607..35680613, -
6.62e-41FFCP PHASE2:Hg19::chr7:131803806..131803815,+#_aa0ab79bbc6ca3ededc7156b531078c1p@chr7:131803806..131803815, +
6.62e-41FFCP PHASE1:Hg19::chr2:35680607..35680613,-#_aa0ab79bbc6ca3ededc7156b531078c1p@chr2:35680607..35680613, -
6.62e-41FFCP PHASE1:Hg19::chr7:131803806..131803815,+#_aa0ab79bbc6ca3ededc7156b531078c1p@chr7:131803806..131803815, +
9.91e-41FFCP PHASE1:Hg19::chr7:115723925..115723935,-#_9d382fbb15d14645a8cbbc9bfa92c267p@chr7:115723925..115723935, -
9.91e-41FFCP PHASE1:Hg19::chrX:106198807..106198826,-#_9d382fbb15d14645a8cbbc9bfa92c267p@chrX:106198807..106198826, -
9.91e-41FFCP PHASE2:Hg19::chr7:115723925..115723935,-#_9d382fbb15d14645a8cbbc9bfa92c267p@chr7:115723925..115723935, -
9.91e-41FFCP PHASE2:Hg19::chrX:106198807..106198826,-#_9d382fbb15d14645a8cbbc9bfa92c267p@chrX:106198807..106198826, -
1.48e-40FFCP PHASE1:Hg19::chr5:34728676..34728679,+#_b2d8d629159b7b77f71c9d9b822b9b5fp26@RAI14
1.48e-40FFCP PHASE2:Hg19::chr5:34728676..34728679,+#_b2d8d629159b7b77f71c9d9b822b9b5fp26@RAI14
2.21e-40FFCP PHASE2:Hg19::chr15:41062022..41062028,+#_4ac871acbbfd7962777640c0b07cd046p3@C15orf62
2.21e-40FFCP PHASE1:Hg19::chr15:41062022..41062028,+#_4ac871acbbfd7962777640c0b07cd046p3@C15orf62
3.3e-40FFCP PHASE1:Hg19::chr3:98671855..98671858,+#_0e48f544e8b7fcffed66b8ce856e45dep@chr3:98671855..98671858, +
3.3e-40FFCP PHASE2:Hg19::chr3:98671855..98671858,+#_0e48f544e8b7fcffed66b8ce856e45dep@chr3:98671855..98671858, +
3.3e-40FFCP PHASE1:Hg19::chr1:94583454..94583465,-#_0e48f544e8b7fcffed66b8ce856e45dep@chr1:94583454..94583465, -
3.3e-40FFCP PHASE1:Hg19::chr4:88447806..88447810,+#_0e48f544e8b7fcffed66b8ce856e45dep@chr4:88447806..88447810, +
3.3e-40FFCP PHASE2:Hg19::chr4:88447806..88447810,+#_0e48f544e8b7fcffed66b8ce856e45dep@chr4:88447806..88447810, +
3.3e-40FFCP PHASE1:Hg19::chr16:80552480..80552487,-#_0e48f544e8b7fcffed66b8ce856e45dep@chr16:80552480..80552487, -
3.3e-40FFCP PHASE2:Hg19::chr1:94583454..94583465,-#_0e48f544e8b7fcffed66b8ce856e45dep@chr1:94583454..94583465, -
3.3e-40FFCP PHASE2:Hg19::chr16:80552480..80552487,-#_0e48f544e8b7fcffed66b8ce856e45dep@chr16:80552480..80552487, -
2.58e-34FFCP PHASE1:Hg19::chr3:98672197..98672201,+#_d4c059cd3d4f9690bfb11ecf040ba348p@chr3:98672197..98672201, +
2.58e-34FFCP PHASE2:Hg19::chr3:98672197..98672201,+#_d4c059cd3d4f9690bfb11ecf040ba348p@chr3:98672197..98672201, +
2.58e-34FFCP PHASE1:Hg19::chr11:31667372..31667383,-#_d4c059cd3d4f9690bfb11ecf040ba348p@chr11:31667372..31667383, -
2.58e-34FFCP PHASE2:Hg19::chr11:31667372..31667383,-#_d4c059cd3d4f9690bfb11ecf040ba348p@chr11:31667372..31667383, -
3.61e-34FFCP PHASE2:Hg19::chr15:69339407..69339410,+#_c259fa6649f3e710c35758af27085c93p3@NOX5
3.61e-34FFCP PHASE1:Hg19::chr15:69339407..69339410,+#_c259fa6649f3e710c35758af27085c93p3@NOX5
7.06e-34FFCP PHASE2:Hg19::chr14:85705824..85705844,-#_7ee221845da8251d40984304e5680e60p1@ENST00000556016
7.06e-34FFCP PHASE1:Hg19::chr1:8938123..8938135,-#_7ee221845da8251d40984304e5680e60p3@ENO1-IT1
7.06e-34FFCP PHASE2:Hg19::chr14:61929802..61929817,+#_7ee221845da8251d40984304e5680e60p35@PRKCH
7.06e-34FFCP PHASE1:Hg19::chr14:85705824..85705844,-#_7ee221845da8251d40984304e5680e60p1@ENST00000556016
7.06e-34FFCP PHASE2:Hg19::chr1:8938123..8938135,-#_7ee221845da8251d40984304e5680e60p3@ENO1-IT1
7.06e-34FFCP PHASE1:Hg19::chr14:61929802..61929817,+#_7ee221845da8251d40984304e5680e60p35@PRKCH
7.48e-30FFCP PHASE2:Hg19::chr8:53853672..53853682,-#_aff71c1c150b5847bc7e138309994cd5p1@BC033145
7.48e-30FFCP PHASE1:Hg19::chr8:53853672..53853682,-#_aff71c1c150b5847bc7e138309994cd5p1@BC033145
9.99e-30FFCP PHASE2:Hg19::chr9:75489043..75489052,-#_72f530a7d56c76cf26709c09c8fd64ebp1@ENST00000453787
9.99e-30FFCP PHASE1:Hg19::chr9:75489043..75489052,-#_72f530a7d56c76cf26709c09c8fd64ebp1@ENST00000453787
1.33e-29FFCP PHASE2:Hg19::chr7:43417422..43417435,+#_bcf270a4585fa99b1f8a09525253ed13p16@HECW1
1.33e-29FFCP PHASE1:Hg19::chr7:43417422..43417435,+#_bcf270a4585fa99b1f8a09525253ed13p16@HECW1
2.37e-29FFCP PHASE1:Hg19::chr21:16374688..16374703,-#_0960bb5529cb87fdb9c298357b68b6cdp6@NRIP1
2.37e-29FFCP PHASE2:Hg19::chr21:16374688..16374703,-#_0960bb5529cb87fdb9c298357b68b6cdp6@NRIP1
3.16e-29FFCP PHASE1:Hg19::chr10:91043389..91043400,+#_76cb0f921a6a00f27e7d38a0995490abp3@ENST00000444849
3.16e-29FFCP PHASE1:Hg19::chr7:151433200..151433217,-#_76cb0f921a6a00f27e7d38a0995490abp31@PRKAG2
3.16e-29FFCP PHASE2:Hg19::chr10:91043389..91043400,+#_76cb0f921a6a00f27e7d38a0995490abp3@ENST00000444849
3.16e-29FFCP PHASE2:Hg19::chr7:151433200..151433217,-#_76cb0f921a6a00f27e7d38a0995490abp31@PRKAG2
4.2e-29FFCP PHASE2:Hg19::chr12:13025302..13025313,+#_8bdf090ec2d01fee10f876ea065e8824p@chr12:13025302..13025313, +
4.2e-29FFCP PHASE1:Hg19::chr12:13025302..13025313,+#_8bdf090ec2d01fee10f876ea065e8824p@chr12:13025302..13025313, +
5.93e-26FFCP PHASE1:Hg19::chr6:125540724..125540736,+#_fa02c448205d268c316f7b4b0e69a059p12@TPD52L1
5.93e-26FFCP PHASE2:Hg19::chr6:125540724..125540736,+#_fa02c448205d268c316f7b4b0e69a059p12@TPD52L1
9.79e-26FFCP PHASE2:Hg19::chr21:41160614..41160621,+#_d5e96e9e9d4adff27b361889021239afp@chr21:41160614..41160621, +
9.79e-26FFCP PHASE1:Hg19::chr21:41160614..41160621,+#_d5e96e9e9d4adff27b361889021239afp@chr21:41160614..41160621, +
2.1e-23FFCP PHASE2:Hg19::chr14:61929948..61929975,+#_74c0255bdc4528f1a65d5c05e4e32485p20@PRKCH
2.1e-23FFCP PHASE1:Hg19::chr14:61929948..61929975,+#_74c0255bdc4528f1a65d5c05e4e32485p20@PRKCH
4.1e-23FFCP PHASE2:Hg19::chr2:16804394..16804406,-#_aaaf9c2fd70676b1ab31771075cbc7a8p6@FAM49A
4.1e-23FFCP PHASE1:Hg19::chr2:16804394..16804406,-#_aaaf9c2fd70676b1ab31771075cbc7a8p6@FAM49A
1.88e-21FFCP PHASE1:Hg19::chr3:55002159..55002164,+#_e609fbfa9aa5a18f5c4acb965b351a36p@chr3:55002159..55002164, +
1.88e-21FFCP PHASE2:Hg19::chr3:55002159..55002164,+#_e609fbfa9aa5a18f5c4acb965b351a36p@chr3:55002159..55002164, +
4.22e-21FFCP PHASE1:Hg19::chr21:16374660..16374679,-#_31e455717e07c20482bfe43002830feap4@NRIP1
4.22e-21FFCP PHASE2:Hg19::chr21:16374660..16374679,-#_31e455717e07c20482bfe43002830feap4@NRIP1
6.31e-21FFCP PHASE2:Hg19::chr8:145011875..145011879,+#_c8a5030b1a87e53e66c40ca224899ff6p@chr8:145011875..145011879, +
6.31e-21FFCP PHASE2:Hg19::chr10:91043499..91043510,+#_c8a5030b1a87e53e66c40ca224899ff6p2@ENST00000354541
6.31e-21FFCP PHASE1:Hg19::chr10:91043499..91043510,+#_c8a5030b1a87e53e66c40ca224899ff6p2@ENST00000354541
6.31e-21FFCP PHASE1:Hg19::chr8:145011875..145011879,+#_c8a5030b1a87e53e66c40ca224899ff6p@chr8:145011875..145011879, +
7.72e-21FFCP PHASE1:Hg19::chr15:67524744..67524745,+#_33999d9bfb37e82c3680affd772f26aap1@ENST00000497294
7.72e-21FFCP PHASE1:Hg19::chr11:31014065..31014073,-#_33999d9bfb37e82c3680affd772f26aap1@DCDC5
7.72e-21FFCP PHASE1:Hg19::chr8:124692287..124692298,+#_33999d9bfb37e82c3680affd772f26aap@chr8:124692287..124692298, +
7.72e-21FFCP PHASE2:Hg19::chr11:31014065..31014073,-#_33999d9bfb37e82c3680affd772f26aap1@DCDC5
7.72e-21FFCP PHASE2:Hg19::chr8:124692287..124692298,+#_33999d9bfb37e82c3680affd772f26aap@chr8:124692287..124692298, +
7.72e-21FFCP PHASE2:Hg19::chr15:67524744..67524745,+#_33999d9bfb37e82c3680affd772f26aap1@ENST00000497294
9.43e-21FFCP PHASE1:Hg19::chr3:150690508..150690520,-#_3a374dffd597f6b18c492ceb5f84d185p1@CLRN1
9.43e-21FFCP PHASE2:Hg19::chr3:150690508..150690520,-#_3a374dffd597f6b18c492ceb5f84d185p1@CLRN1
1.3e-19FFCP PHASE2:Hg19::chr14:87636652..87636657,-#_95eb48ae6c7dfdf4cf4109c2242d73e0p@chr14:87636652..87636657, -
1.3e-19FFCP PHASE1:Hg19::chr14:87636652..87636657,-#_95eb48ae6c7dfdf4cf4109c2242d73e0p@chr14:87636652..87636657, -
2.25e-19FFCP PHASE1:Hg19::chr14:61929781..61929801,+#_81c7825edab1505f3072a32f38548e09p27@PRKCH
2.25e-19FFCP PHASE2:Hg19::chr14:61929781..61929801,+#_81c7825edab1505f3072a32f38548e09p27@PRKCH
3.25e-19FFCP PHASE1:Hg19::chr3:147131290..147131301,+#_ec0e5ee81ef4f1d364ba916a2b9028b4p@chr3:147131290..147131301, +
3.25e-19FFCP PHASE2:Hg19::chrX:106243285..106243290,-#_ec0e5ee81ef4f1d364ba916a2b9028b4p8@MORC4
3.25e-19FFCP PHASE2:Hg19::chr3:147131290..147131301,+#_ec0e5ee81ef4f1d364ba916a2b9028b4p@chr3:147131290..147131301, +
3.25e-19FFCP PHASE1:Hg19::chrX:106243285..106243290,-#_ec0e5ee81ef4f1d364ba916a2b9028b4p8@MORC4
3.91e-19FFCP PHASE2:Hg19::chr14:62037117..62037132,+#_ed56314f5b51440414a40d515c6622c4p7@FLJ22447
3.91e-19FFCP PHASE1:Hg19::chr14:62037117..62037132,+#_ed56314f5b51440414a40d515c6622c4p7@FLJ22447
4.44e-18FFCP PHASE1:Hg19::chr4:150666211..150666212,+#_d635aa3f06c2b21352d523927871b1b7p@chr4:150666211..150666212, +
4.44e-18FFCP PHASE2:Hg19::chr4:150666211..150666212,+#_d635aa3f06c2b21352d523927871b1b7p@chr4:150666211..150666212, +
5.26e-18FFCP PHASE1:Hg19::chr1:29586692..29586705,+#_d2bd59e288365c9cbc10e62943361fa5p7@PTPRU
5.26e-18FFCP PHASE2:Hg19::chr1:29586692..29586705,+#_d2bd59e288365c9cbc10e62943361fa5p7@PTPRU
6.23e-18FFCP PHASE1:Hg19::chr5:138852090..138852095,+#_11e67a37f27061f3a787282864504655p@chr5:138852090..138852095, +
6.23e-18FFCP PHASE2:Hg19::chr5:138852090..138852095,+#_11e67a37f27061f3a787282864504655p@chr5:138852090..138852095, +

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