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Coexpression cluster:C4499

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Full id: C4499_Fibroblast_ovary_Cardiac_kidney_Mesenchymal_left_heart



Phase1 CAGE Peaks

Hg19::chr5:40909592..40909608,+p1@C7
Hg19::chr5:40909642..40909649,+p2@C7
Hg19::chr5:40910094..40910097,+p@chr5:40910094..40910097
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism2.62e-56115
regional part of brain6.36e-1859
regional part of nervous system1.30e-1794
nervous system1.30e-1794
brain8.79e-1769
future brain8.79e-1769
multi-tissue structure2.00e-16347
neural tube2.53e-1657
neural rod2.53e-1657
future spinal cord2.53e-1657
neural keel2.53e-1657
central nervous system3.44e-1682
neural plate3.22e-1486
presumptive neural plate3.22e-1486
neurectoderm1.29e-1390
anatomical cluster2.68e-13286
anterior region of body5.38e-13129
craniocervical region5.38e-13129
organism subdivision2.37e-12365
cell layer1.06e-11312
anatomical conduit1.32e-11241
head2.72e-11123
multi-cellular organism7.04e-11659
epithelium8.14e-11309
organ9.10e-11511
tube1.34e-10194
embryo2.82e-10612
anterior neural tube3.30e-1042
embryonic structure8.53e-10605
developing anatomical structure8.53e-10605
regional part of forebrain1.33e-0941
forebrain1.33e-0941
future forebrain1.33e-0941
primary circulatory organ1.48e-0927
ectoderm-derived structure1.73e-09169
germ layer2.04e-09604
embryonic tissue2.04e-09604
presumptive structure2.04e-09604
epiblast (generic)2.04e-09604
ectoderm2.78e-09173
presumptive ectoderm2.78e-09173
anatomical system5.89e-09625
anatomical group7.39e-09626
compound organ3.79e-0869
posterior neural tube7.09e-0815
chordal neural plate7.09e-0815
endocrine gland1.00e-0735
immune organ1.07e-0726
heart1.87e-0724
primitive heart tube1.87e-0724
primary heart field1.87e-0724
anterior lateral plate mesoderm1.87e-0724
heart tube1.87e-0724
heart primordium1.87e-0724
cardiac mesoderm1.87e-0724
cardiogenic plate1.87e-0724
heart rudiment1.87e-0724
telencephalon3.68e-0734
tissue4.74e-07787
gray matter5.38e-0734
brain grey matter5.38e-0734
pre-chordal neural plate5.41e-0761
regional part of telencephalon8.24e-0733
subdivision of digestive tract9.16e-07129
endodermal part of digestive tract9.16e-07129


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.