MCL coexpression mm9:1091

Phase1 CAGE Peaks

	Short description
Mm9::chr11:84683533..84683609,-	p2@Ggnbp2
Mm9::chr11:84683630..84683684,-	p3@Ggnbp2
Mm9::chr11:84684214..84684309,-	p1@Ggnbp2
Mm9::chr19:46227013..46227056,+	p1@Gbf1
Mm9::chr1:192752380..192752429,+	p2@Angel2
Mm9::chr6:86683262..86683388,-	p1@Gmcl1
Mm9::chr6:97129094..97129153,-	p1@Tmf1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007283	spermatogenesis	0.0120815599975684
GO:0048232	male gamete generation	0.0120815599975684
GO:0050220	prostaglandin-E synthase activity	0.0120815599975684
GO:0007276	gamete generation	0.0120815599975684
GO:0019953	sexual reproduction	0.013172754452041
GO:0015035	protein disulfide oxidoreductase activity	0.0142935359858534
GO:0046457	prostanoid biosynthetic process	0.0142935359858534
GO:0001516	prostaglandin biosynthetic process	0.0142935359858534
GO:0000003	reproduction	0.0150846207950959
GO:0006693	prostaglandin metabolic process	0.0154804218436046
GO:0006692	prostanoid metabolic process	0.0154804218436046
GO:0015036	disulfide oxidoreductase activity	0.0154804218436046
GO:0016363	nuclear matrix	0.0164862161938072
GO:0046456	icosanoid biosynthetic process	0.0244817277806222
GO:0006690	icosanoid metabolic process	0.0285526234360812
GO:0045454	cell redox homeostasis	0.0360849429900489
GO:0016860	intramolecular oxidoreductase activity	0.0360849429900489
GO:0005634	nucleus	0.0483232202533136
GO:0006633	fatty acid biosynthetic process	0.0495102897600699
GO:0016053	organic acid biosynthetic process	0.0495102897600699
GO:0046394	carboxylic acid biosynthetic process	0.0495102897600699

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
intestine	3.35e-08	31
endoderm-derived structure	8.33e-07	118
endoderm	8.33e-07	118
presumptive endoderm	8.33e-07	118

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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