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Coexpression cluster:C1115

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Full id: C1115_CD4_CD34_CD8_CD19_Basophils_Peripheral_Dendritic



Phase1 CAGE Peaks


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>



Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#110657.38858773865490.0001498689600820670.00193141218188685
E2F1#186953.505278010628090.005090553587915050.0236837280010807
E2F4#187435.429168706550470.01350675082176140.0477032075030923
EGR1#195853.562985067721530.004722351211058930.0222552068106937
ELF1#199753.041498542005380.009719562269370750.0365565169926106
EP300#203343.870823843556110.01142567586684480.041859408631473
FOS#235345.141688747939660.004042095865678250.0193479284163147
GTF2B#2959418.25361710532813.11241110089347e-050.0006292239701243
GTF2F1#296235.459854661467560.0132988216841570.0470213161985129
HEY1#2346263.462952322662040.001267890095872120.00850354313657776
IRF1#365944.364093573465090.00739345582427820.0305493405931236
NANOG#79923312.53347649186260.001261052189503470.00846747007969353
NFKB1#479053.92004530299560.003036581424484610.0161155306363
NFYA#4800615.7933548855691.7032585757508e-079.38220582240704e-06
NFYB#4801614.36553707445982.99325254948281e-071.50947514734638e-05
PAX5#507943.811180303530190.01208261681555190.0438204124596112
POLR2A#543072.147453176558070.004747636447610280.0223219917594188
REST#597856.892877654377160.0002094388584846510.00243825492601477
RFX5#5993610.32678070902442.12421369818918e-067.73538195345816e-05
SP1#666764.884326895549340.0001736361122290910.00211282557673238
SP2#6668414.94487456791126.81071539656055e-050.00108762126192873
TAF1#687262.865468244924540.003728330207471460.0185818696510671
TBP#690863.177232017511190.002074112051852660.0120149863322114
TCF7L2#693446.154386607507050.002064676148138040.0119689560521419
TRIM28#1015537.967367876541080.004622341263156460.0218311716719937
YY1#752853.507979107038470.005072570672808980.0236095284325281



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.