MCL coexpression mm9:2733

Phase1 CAGE Peaks

	Short description
Mm9::chr11:87800997..87801014,-	p1@Dynll2
Mm9::chr9:114597969..114597983,+	p3@Dync1li1
Mm9::chr9:114597984..114597995,+	p5@Dync1li1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030286	dynein complex	0.000121865652926932
GO:0003777	microtubule motor activity	0.000312168174985246
GO:0005875	microtubule associated complex	0.000515377650432372
GO:0007017	microtubule-based process	0.00108928683367448
GO:0005874	microtubule	0.00108928683367448
GO:0015630	microtubule cytoskeleton	0.00203884839287239
GO:0007010	cytoskeleton organization and biogenesis	0.00427434558388796
GO:0044430	cytoskeletal part	0.00506297758804196
GO:0046907	intracellular transport	0.0053704932565731
GO:0005868	cytoplasmic dynein complex	0.00547720074331084
GO:0051649	establishment of cellular localization	0.00651053243215824
GO:0051641	cellular localization	0.00651053243215824
GO:0005856	cytoskeleton	0.00850868390029496
GO:0006996	organelle organization and biogenesis	0.0129359189935112
GO:0016459	myosin complex	0.0188828728078335
GO:0043232	intracellular non-membrane-bound organelle	0.0188828728078335
GO:0043228	non-membrane-bound organelle	0.0188828728078335
GO:0043234	protein complex	0.0202259463645369
GO:0007018	microtubule-based movement	0.0238788590423317
GO:0030705	cytoskeleton-dependent intracellular transport	0.026773568778255
GO:0032991	macromolecular complex	0.0275248713861544
GO:0006810	transport	0.0310556537513799
GO:0044446	intracellular organelle part	0.0310556537513799
GO:0044422	organelle part	0.0310556537513799
GO:0016043	cellular component organization and biogenesis	0.0310556537513799
GO:0051234	establishment of localization	0.0310556537513799
GO:0051179	localization	0.0369834062872931
GO:0015629	actin cytoskeleton	0.0369834062872931

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	8.38e-11	23
neuroblast (sensu Vertebrata)	8.38e-11	23
neuron	4.32e-10	33
neuronal stem cell	4.32e-10	33
neuroblast	4.32e-10	33
electrically signaling cell	4.32e-10	33
embryonic cell	4.97e-10	70
ectodermal cell	1.01e-08	44
neurectodermal cell	1.01e-08	44
neural cell	1.47e-08	43
electrically responsive cell	1.01e-07	39
electrically active cell	1.01e-07	39
non-terminally differentiated cell	8.18e-07	49

Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	1.84e-21	92
nervous system	8.10e-20	75
central nervous system	2.21e-19	73
ectoderm-derived structure	2.23e-19	95
ectoderm	2.23e-19	95
presumptive ectoderm	2.23e-19	95
regional part of nervous system	4.94e-19	54
neurectoderm	1.16e-18	64
neural plate	1.16e-18	64
presumptive neural plate	1.16e-18	64
neural tube	1.45e-17	52
neural rod	1.45e-17	52
future spinal cord	1.45e-17	52
neural keel	1.45e-17	52
ecto-epithelium	1.49e-17	73
brain	2.36e-14	47
future brain	2.36e-14	47
regional part of brain	5.10e-14	46
gray matter	1.86e-13	34
pre-chordal neural plate	2.94e-13	49
anterior neural tube	2.92e-12	40
regional part of forebrain	8.40e-12	39
forebrain	8.40e-12	39
future forebrain	8.40e-12	39
brain grey matter	1.86e-10	29
regional part of telencephalon	1.86e-10	29
telencephalon	1.86e-10	29
anatomical cluster	1.62e-08	244
tube	1.56e-07	114
anatomical conduit	1.74e-07	122
cerebral cortex	5.21e-07	21
cerebral hemisphere	5.21e-07	21
pallium	5.21e-07	21
regional part of cerebral cortex	6.99e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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